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Untargeted metabolomic profiling in a patient with glycogen storage disease Ib receiving empagliflozin treatment
Publication Type: Academic Journal
Source(s): JIMD Reports, Vol 63, Iss 4, Pp 309-315 (2022)
Abstract: Abstract Glycogen storage disease type Ib (GSD‐Ib) is a rare inborn error of glycogen metabolism uniquely associated with neutropenia and neutrophil dysfunction, causing severe infections, inflammatory bowel disease (IBD), and impaired wound healing. R...
Safety, tolerability and efficacy of agonist anti-CD27 antibody (varlilumab) administered in combination with anti-PD-1 (nivolumab) in advanced solid tumors
Publication Type: Academic Journal
Source(s): Journal for ImmunoTherapy of Cancer, Vol 10, Iss 8 (2022)
Abstract: Background Phase 1/2 dose-escalation and expansion study evaluating varlilumab, a fully human agonist anti-CD27 mAb, with nivolumab in anti-PD-1/L1 naïve, refractory solid tumors.Methods Phase 1 evaluated the safety of varlilumab (0.1–10 mg/kg) with ni...
The Effect of Two Interventions to Increase Breast Cancer Screening in Rural Women
Publication Type: Academic Journal
Source(s): Cancers, Vol 14, Iss 4354, p 4354 (2022)
Abstract: Guideline-based mammography screening is essential to lowering breast cancer mortality, yet women residing in rural areas have lower rates of up to date (UTD) breast cancer screening compared to women in urban areas. We tested the comparative effective...
Myxomavirus Serp-1 Protein Ameliorates Inflammation in a Mouse Model of Duchenne Muscular Dystrophy
Publication Type: Academic Journal
Source(s): Biomedicines, Vol 10, Iss 1154, p 1154 (2022)
Abstract: Duchenne muscular dystrophy is an X-linked disease afflicting 1 in 3500 males that is characterized by muscle weakness and wasting during early childhood, and loss of ambulation and death by early adulthood. Chronic inflammation due to myofiber instabi...
Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract: Abstract Lung cancer rates are rising globally and non-small cell lung cancer (NSCLC) has a five year survival rate of only 24%. Unfortunately, the development of drugs to treat cancer is severely hampered by the inefficiency of translating pre-clinica...
Inhibition of the AT1R agonistic autoantibody in a rat model of preeclampsia improves fetal growth in late gestation.
Publication Type: Academic Journal
Source(s): American Journal of Physiology: Regulatory, Integrative & Comparative Physiology; Nov2022, Vol. 323 Issue 5, pR670-R681, 12p
Abstract: Copyright of American Journal of Physiology: Regulatory, Integrative & Comparative Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright...
Untargeted metabolomic profiling in a patient with glycogen storage disease Ib receiving empagliflozin treatment.
Publication Type: Academic Journal
Source(s): Journal of Inherited Metabolic Disease Reports; Jul2022, Vol. 63 Issue 4, p309-315, 7p
Myxomavirus Serp-1 Protein Ameliorates Inflammation in a Mouse Model of Duchenne Muscular Dystrophy.
Publication Type: Academic Journal
Source(s): Biomedicines; May2022, Vol. 10 Issue 5, p1154, 13p
Abstract: Copyright of Biomedicines is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles fo...
Soluble guanylate cyclase stimulation in late gestation does not mitigate asymmetric intrauterine growth restriction or cardiovascular risk induced by placental ischemia in the rat.
Publication Type: Academic Journal
Source(s): American Journal of Physiology: Heart & Circulatory Physiology; May2021, Vol. 320 Issue 5, pH1923-H1934, 12p, 1 Chart, 10 Graphs
Abstract: Copyright of American Journal of Physiology: Heart & Circulatory Physiology is the property of American Physiological Society and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express ...
Validation of a multicellular tumor microenvironment system for modeling patient tumor biology and drug response.
Publication Type: Academic Journal
Source(s): Scientific Reports; 3/10/2021, Vol. 11 Issue 1, p1-15, 15p
Abstract: Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or ...