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Advanced Search Results For "Rice, Tom W."

1 - 10 of 237 results for
 "Rice, Tom W."
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Prognostic indicators and outcomes of hospitalised COVID-19 patients with neurological disease: An individual patient data meta-analysis

Publication Type: Academic Journal

Source(s): PLoS ONE, Vol 17, Iss 6 (2022)

Abstract: Background Neurological COVID-19 disease has been reported widely, but published studies often lack information on neurological outcomes and prognostic risk factors. We aimed to describe the spectrum of neurological disease in hospitalised COVID-19 pat...

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Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 35, Iss 13, Pp 109292- (2021)

Abstract: Summary: We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding...

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 313-326.e5 (2018)

Abstract: Summary: Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic sub...

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 227-238.e3 (2018)

Abstract: Summary: Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% ...

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 181-193.e7 (2018)

Abstract: Summary: Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images f...

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 255-269.e4 (2018)

Abstract: Summary: Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven...

Systematic Analysis of Splice-Site-Creating Mutations in Cancer

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 270-281.e3 (2018)

Abstract: Summary: For the past decade, cancer genomic studies have focused on mutations leading to splice-site disruption, overlooking those having splice-creating potential. Here, we applied a bioinformatic tool, MiSplice, for the large-scale discovery of spli...

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 239-254.e6 (2018)

Abstract: Summary: DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying ...

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 282-296.e4 (2018)

Abstract: Summary: Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer. We analyzed whole-exome sequencing data across 33 tumor types in The C...

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