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Advanced Search Results For "Rosen, Jeffrey"

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 "Rosen, Jeffrey"
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Single-cell RNA transcriptome analysis of CNS immune cells reveals CXCL16/CXCR6 as maintenance factors for tissue-resident T cells that drive synapse elimination

Publication Type: Academic Journal

Source(s): Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)

Abstract: Abstract Background Emerging RNA viruses that target the central nervous system (CNS) lead to cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus (WNV), a re-emerging RNA virus associated with learning and memory d...

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Abstract: SIVmac239 infection of macaques is a favored model of human HIV infection, but antibody-mediated protection for SIVmac239 is insufficiently understood. Here, Zhao and Berndsen et al isolated nAbs and confirmed protection against SIVmac239 infection in ...


Insights into Sickle Cell Disease through the Retinal Microvasculature

Publication Type: Academic Journal

Source(s): Ophthalmology Science, Vol 2, Iss 4, Pp 100196- (2022)

Abstract: Purpose: Clinical OCT angiography (OCTA) of the retinal microvasculature offers a quantitative correlate to systemic disease burden and treatment efficacy in sickle cell disease (SCD). The purpose of this study was to use the higher resolution of adapt...

Sex Modulates the Pathological Aging Effect on Caudate Functional Connectivity in Mild Cognitive Impairment

Publication Type: Academic Journal

Source(s): Frontiers in Psychiatry, Vol 13 (2022)

Abstract: PurposeTo assess the pathological aging effect on caudate functional connectivity among mild cognitive impairment (MCI) participants and examine whether and how sex and amyloid contribute to this process.Materials and MethodsTwo hundred and seventy-sev...

Hyperexcitability: From Normal Fear to Pathological Anxiety and Trauma

Publication Type: Academic Journal

Source(s): Frontiers in Systems Neuroscience, Vol 16 (2022)

Abstract: Hyperexcitability in fear circuits is suggested to be important for development of pathological anxiety and trauma from adaptive mechanisms of fear. Hyperexcitability is proposed to be due to acquired sensitization in fear circuits that progressively b...

Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence

Publication Type: Academic Journal

Source(s): The Journal of Clinical Investigation, Vol 132, Iss 8 (2022)

Abstract: Mice with experimental nerve damage can display long‑lasting neuropathic pain behavior. We show here that 4 months and later after nerve injury, male but not female mice displayed telomere length (TL) reduction and p53‑mediated cellular senescence in t...

The efficacy of bactrim in reducing surgical site infections after spine surgery

Publication Type: Academic Journal

Source(s): North American Spine Society Journal, Vol 9, Iss , Pp 100095- (2022)

Abstract: Background: Previous studies show an increasing incidence of gram-negative organisms in surgical site infections after spine surgery. This study is looking for the association of the post-operative prophylactic use of Bactrim and the gram-negative surg...

Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Abstract: The epithelial-mesenchymal transition (EMT) has been implicated in stem cell properties and therapeutic resistance in cancer. Here, the authors show organoids derived from mesenchymal breast cancers exhibit a spikey structure which can be reverted and ...