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Advanced Search Results For "Rossi, Stephen A."

1 - 10 of 1,118 results for
 "Rossi, Stephen A."
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Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium

Publication Type: Academic Journal

Source(s): Hereditary Cancer in Clinical Practice, Vol 20, Iss 1, Pp 1-11 (2022)

Abstract: Abstract Objective To compare colorectal cancer (CRC) incidences in carriers of pathogenic variants of the MMR genes in the PLSD and IMRC cohorts, of which only the former included mandatory colonoscopy surveillance for all participants. Methods CRC in...

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A community jury study exploring the public acceptability of using risk stratification to determine eligibility for cancer screening

Publication Type: Academic Journal

Source(s): Health Expectations, Vol 25, Iss 4, Pp 1789-1806 (2022)

Abstract: Abstract Introduction Using risk stratification to determine eligibility for cancer screening is likely to improve the efficiency of screening programmes by targeting resources towards those most likely to benefit. We aimed to explore the implications ...

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In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Abstract: Standard assessment of immune infiltration of biopsies is not sufficient to accurately predict response to immunotherapy. Here, the authors show that reflectance confocal microscopy can be used to quantify dynamic vasculature and inflammatory features ...

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SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia

Publication Type: Academic Journal

Source(s): Redox Biology, Vol 58, Iss , Pp 102508- (2022)

Abstract: Rationale: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 pneumonia. We hypothesize that SARS-CoV-2 causes alveolar injury and hypoxemia by damaging mitochondria in airway epithelial cells (AEC) and pulmonary artery smooth...

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Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs

Publication Type: Academic Journal

Source(s): Frontiers in Immunology, Vol 13 (2022)

Abstract: The most commonly used markers to assess complement activation are split products that are produced through activation of all three pathways and are located downstream of C3. In contrast, C4d derives from the cleavage of C4 and indicates either classic...

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Association of body mass index with outcomes in patients with newly diagnosed atrial fibrillation: GARFIELD-AF

Publication Type: Academic Journal

Source(s): Open Heart, Vol 9, Iss 2 (2022)

Abstract: Objective While greater body mass index (BMI) is associated with increased risk of developing atrial fibrillation (AF), the impact of BMI on outcomes in newly diagnosed AF is unclear. We examine the influence of BMI on outcomes and whether this is modi...

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The Yorkshire Kidney Screening Trial (YKST): protocol for a feasibility study of adding non-contrast abdominal CT scanning to screen for kidney cancer and other abdominal pathology within a trial of community-based CT screening for lung cancer

Publication Type: Academic Journal

Source(s): BMJ Open, Vol 12, Iss 9 (2022)

Abstract: Introduction Kidney cancer (renal cell cancer (RCC)) is the seventh most common cancer in the UK. As RCC is largely curable if detected at an early stage and most patients have no symptoms, there is international interest in evaluating a screening prog...

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Leishmania guyanensis suppressed inducible nitric oxide synthase provoked by its viral endosymbiont

Publication Type: Academic Journal

Source(s): Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Abstract: Inducible nitric oxide synthase (iNOS) is essential to the production of nitric oxide (NO), an efficient effector molecule against intracellular human pathogens such as Leishmania protozoan parasites. Some strains of Leishmania are known to bear a vira...

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LRG1: an emerging player in disease pathogenesis

Publication Type: Academic Journal

Source(s): Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-29 (2022)

Abstract: Abstract The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a decade ago. Since then, an increasing number of publications have reported the involvement of...

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ANALOG-1 ISS – The first part of an analogue mission to guide ESA’s robotic moon exploration efforts

Publication Type: Academic Journal

Source(s): Open Astronomy, Vol 31, Iss 1, Pp 5-14 (2022)

Abstract: The European Space Agency’s ANALOG-1 experiment is the culmination of 12 distinct METERON experiments carried out since 2011. These all address aspects of teleoperating a robotic asset from an orbital platform, i.e., technical implementation, user inte...

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