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Differential response to microbial antigens by age of diagnosis in patients with Crohn's disease
Publication Type: Academic Journal
Source(s): Clinical and Experimental Gastroenterology, Vol 2015, Iss default, Pp 169-174 (2015)
Abstract: Sandra M Quezada, Ankur Rustgi, Guruprasad D Jambaulikar, Raymond K Cross Department of Medicine, Division of Gastroenterology and Hepatology, University of Maryland School of Medicine, Baltimore, MD, USA Purpose: Fifteen percent of incident Crohn's di...
Alterations of the fecal microbiota in relation to acute COVID-19 infection and recovery
Publication Type: Academic Journal
Source(s): Molecular Biomedicine, Vol 3, Iss 1, Pp 1-14 (2022)
Abstract: Abstract People with acute COVID-19 due to SARS-CoV-2 infection experience a range of symptoms, but major factors contributing to severe clinical outcomes remain to be understood. Emerging evidence suggests associations between the gut microbiome and t...
Tumor suppressor mediated ubiquitylation of hnRNPK is a barrier to oncogenic translation
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract: Cytoplasmic accumulation of RNA binding protein, hnRNPK in cancer cells is associated with poor prognosis. Here the authors show that SCFFbxo4 E3 ubiquitin ligase-mediated polyubiquitylation of hnRNPK restricts c-Myc translation and limits cancer progr...
Plant biomacromolecule delivery methods in the 21st century
Publication Type: Academic Journal
Source(s): Frontiers in Genome Editing, Vol 4 (2022)
Abstract: The 21st century witnessed a boom in plant genomics and gene characterization studies through RNA interference and site-directed mutagenesis. Specifically, the last 15 years marked a rapid increase in discovering and implementing different genome editi...
Wilson’s Disease: An Analysis of Health Care Use and Cost Burden of Commercially Insured Adults in the United States
Publication Type: Academic Journal
Source(s): Hepatology Communications, Vol 6, Iss 2, Pp 389-398 (2022)
Abstract: The economic and health care use burdens of Wilson’s disease (WD) are unknown. In this study, we aimed to quantify this health care resource use and economic burden. We performed a retrospective case‐control analysis of individuals in the Truven Health...
Patient-derived organoids as a platform for modeling a patient’s response to chemoradiotherapy in esophageal cancer
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract: Abstract 3D patient-derived organoids (PDOs) have been utilized to evaluate potential therapies for patients with different cancers. However, the use of PDOs created from treatment-naive patient biopsies for prediction of clinical outcomes in patients ...
Targeting hepatic kisspeptin receptor ameliorates nonalcoholic fatty liver disease in a mouse model
Publication Type: Academic Journal
Source(s): The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Abstract: Nonalcoholic fatty liver disease (NAFLD), the most common liver disease, has become a silent worldwide pandemic. The incidence of NAFLD correlates with the rise in obesity, type 2 diabetes, and metabolic syndrome. A hallmark featureof NAFLD is excessiv...
Genetic mutation and biological pathway prediction based on whole slide images in breast carcinoma using deep learning
Publication Type: Academic Journal
Source(s): npj Precision Oncology, Vol 5, Iss 1, Pp 1-11 (2021)
Abstract: Abstract Breast carcinoma is the most common cancer among women worldwide that consists of a heterogeneous group of subtype diseases. The whole-slide images (WSIs) can capture the cell-level heterogeneity, and are routinely used for cancer diagnosis by...
Hepatic Encephalopathy: A Review
Publication Type: Academic Journal
Source(s): European Medical Journal Hepatology, Vol 9, Iss 1, Pp 89-97 (2021)
Abstract: Hepatic encephalopathy (HE) is a reversible syndrome observed in patients with liver disease. The syndrome is characterised by a spectrum of neuropsychiatric abnormalities resulting from the accumulation of neurotoxic substances in the bloodstream and ...
Targeting Induced Local Lesions in the Wheat DEMETER and DRE2 Genes, Responsible for Transcriptional Derepression of Wheat Gluten Proteins in the Developing Endosperm
Publication Type: Academic Journal
Source(s): Frontiers in Nutrition, Vol 9 (2022)
Abstract: Wheat is a major source of energy and nutrition worldwide, but it is also a primary cause of frequent diet-induced health issues, specifically celiac disease, for which the only effective therapy so far is strict dietary abstinence from gluten-containi...