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Hypertrophic gastropathy in Helicobacter felis-infected wild-type C57BL/6 mice and p53 hemizygous transgenic mice
Publication Type: Periodical
Source(s): Gastroenterology; January 1996, Vol. 110 Issue: 1 p155-166, 12p
Abstract: BACKGROUND & AIMS:Helicobacter pylori infection causes gastritis and peptic ulcers and is linked epidemiologically to gastric cancer. To analyze host genetic factors and the influence of Helicobacter on cell proliferation, we used an inbred and p53 hem...
MAD about colorectal cancer
Publication Type: Periodical
Source(s): Gastroenterology; November 1996, Vol. 111 Issue: 5 p1387-1389, 3p
Abstract: This article has no abstract. To view the article, select the "View Print Version (PDF)" link above.
Trans-activation of the esophageal squamous epithelial specific human keratin 4 and epstein-barr virus ED-L2 promoters by gut-enriched Krüppel-like Factor
Publication Type: Periodical
Source(s): Gastroenterology; April 1998, Vol. 114 Issue: 1, Number 1 Supplement 1 pA616-A617, 2p
The human keratin 4 promoter is regulated by esophageal-specific and ubiquitous transcriptional activators
Publication Type: Periodical
Source(s): Gastroenterology; April 1998, Vol. 114 Issue: 1, Number 1 Supplement 1 pA658-A658, 1p
Cellular characterization and successful transfection of serially subcultured normal human esophageal keratinocytes
Publication Type: Periodical
Source(s): Gastroenterology; April 1998, Vol. 114 Issue: 1, Number 1 Supplement 1 pA658-A658, 1p
Cooperation between the cyclin D1 oncogene and the chemical carcinogen N-nitrosomethylbenzylamine in the induction of esophageal dysplasia in transgenic mice
Publication Type: Periodical
Source(s): Gastroenterology; April 1998, Vol. 114 Issue: 1, Number 1 Supplement 1 pA616-A616, 1p
Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells.
Publication Type: Academic Journal
Source(s): Molecular cancer research : MCR [Mol Cancer Res] 2023 Mar 01; Vol. 21 (3), pp. 228-239.
Abstract: Cholesterol dependence is an essential characteristic of pancreatic ductal adenocarcinoma (PDAC). Cholesterol 25-hydroxylase (CH25H) catalyzes monooxygenation of cholesterol into 25-hydroxycholesterol, which is implicated in inhibiting cholesterol bios...
Phase Ib and Expansion Study of Gemcitabine, Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer.
Publication Type: Academic Journal
Source(s): The oncologist [Oncologist] 2023 Feb 18. Date of Electronic Publication: 2023 Feb 18.
Abstract: Background: In preclinical pancreatic ductal adenocarcinoma (PDAC) models, inhibition of hepatocyte growth factor (HGF) signaling using ficlatuzumab, a recombinant humanized anti-HGF antibody, and gemcitabine reduced tumor burden.Methods: Patients with...
Tumor Niche Network-Defined Subtypes Predict Immunotherapy Response of Esophageal Squamous Cell Cancer.
Source(s): BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 15. Date of Electronic Publication: 2023 Feb 15.
Abstract: Despite the promising outcomes of immune checkpoint blockade (ICB), resistance to ICB presents a new challenge. Therefore, selecting patients for specific ICB applications is crucial for maximizing therapeutic efficacy. Herein we curated 69 human esoph...
SOX9 Modulates the Transformation of Gastric Stem Cells Through Biased Symmetric Cell Division.
Publication Type: Academic Journal
Source(s): Gastroenterology [Gastroenterology] 2023 Feb 04. Date of Electronic Publication: 2023 Feb 04.
Abstract: Background & Aims: Transformation of stem/progenitor cells has been associated with tumorigenesis in multiple tissues, but stem cells in the stomach have been hard to localize. We therefore aimed to use a combination of several markers to better target...