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Targeted next-generation sequencing for detection of PIK3CA mutations in archival tissues from patients with Klippel–Trenaunay syndrome in an Asian population
Publication Type: Academic Journal
Source(s): Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-12 (2023)
Abstract: Abstract Background Klippel–Trenaunay syndrome (KTS) is a rare slow-flow combined vascular malformation with limb hypertrophy. KTS is thought to lie on the PIK3CA-related overgrowth spectrum, but reports are limited. PIK3CA encodes p110α, a catalytic s...
Occupational radiation exposure to the lens of the eyes and its protection during endoscopic retrograde cholangiopancreatography
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract: Abstract This study aimed to examine occupational radiation exposure to the lens of the eyes during endoscopic retrograde cholangiopancreatography (ERCP). In this multicenter, prospective, observational cohort study, we collected data regarding occupat...
l-Lactate treatment by photosynthetic cyanobacteria expressing heterogeneous l-lactate dehydrogenase
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract: Abstract l-Lactate is a major waste compound in cultured animal cells. To develop a sustainable animal cell culture system, we aimed to study the consumption of l-lactate using a photosynthetic microorganism. As genes involved in l-lactate utilization ...
CD79B Y196 mutation is a potent predictive marker for favorable response to R‐MPV in primary central nervous system lymphoma
Publication Type: Academic Journal
Source(s): Cancer Medicine, Vol 12, Iss 6, Pp 7116-7126 (2023)
Abstract: Abstract Background Rituximab, high‐dose methotrexate (HD‐MTX), procarbazine and vincristine (R‐MPV), has significantly prolonged the survival of patients with primary central nervous system lymphoma (PCNSL), but predictive factors for response to R‐MP...
Therapeutic plasma exchange in postpartum HELLP syndrome: a case report
Publication Type: Academic Journal
Source(s): JA Clinical Reports, Vol 9, Iss 1, Pp 1-4 (2023)
Abstract: Abstract Background Postpartum hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome is more difficult to treat than HELLP syndrome during pregnancy. We describe a case of postpartum HELLP syndrome that responded to plasma exchange...
Murine breast cancers disorganize the liver transcriptome in a zonated manner
Publication Type: Academic Journal
Source(s): Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract: Spatial transcriptomics reveal how distant cancer affect gene expression and zonation in mouse liver in a manner that differs between biological pathways.
Imaging features of localized IDH wild-type histologically diffuse astrocytomas: a single-institution case series
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract: Abstract Isocitrate dehydrogenase wild-type (IDHwt) diffuse astrocytomas feature highly infiltrative patterns, such as a gliomatosis cerebri growth pattern with widespread involvement. Among these tumors, localized IDHwt histologically diffuse astrocyt...
National trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study
Publication Type: Academic Journal
Source(s): BMJ Open, Vol 13, Iss 4 (2023)
Abstract: Objectives To examine the national, 6-year trends in in-hospital clinical outcomes of patients with subarachnoid haemorrhage (SAH) who underwent clipping or coiling and the prognostic influence of temporal trends in the Comprehensive Stroke Center (CSC...
Efficacy of gel immersion endoscopic ultrasonography for delineating the duodenal papilla and pancreatobiliary ducts: A retrospective study with video
Publication Type: Academic Journal
Source(s): DEN Open, Vol 3, Iss 1, Pp n/a-n/a (2023)
Abstract: Abstract Objectives Endoscopic ultrasonography is an important examination for periampullary diseases. The duodenum is filled with water to ensure a clear image and distend the duodenal wall without burying the papilla within duodenal folds; however, p...
Clinical features of very early-onset inflammatory bowel disease in Japan: a retrospective single-center study
Publication Type: Academic Journal
Source(s): Intestinal Research, Vol 20, Iss 4, Pp 475-481 (2022)
Abstract: Background/Aims Very early-onset inflammatory bowel disease (VEO-IBD), defined as IBD diagnosed in patients younger than 6 years, is a challenge for pediatric gastroenterologists. Although there have been reports regarding VEO-IBD in Western countries,...