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    • Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis

    Publication Type: Academic Journal

    Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

    Abstract: The genetic basis of primary sclerosing cholangitis has only been partially uncovered. Here, the authors perform a multitrait genome-wide association study to provide insight into the genetic etiology of primary sclerosing cholangitis risk and possible...

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    Pre-exposure prophylaxis (PrEP) for HIV prevention among people who inject drugs: a global mapping of service delivery

    Publication Type: Academic Journal

    Source(s): Harm Reduction Journal, Vol 20, Iss 1, Pp 1-8 (2023)

    Abstract: Abstract Background The World Health Organization (WHO) recommends oral pre-exposure prophylaxis (PrEP) for all people at substantial risk of HIV as part of combination prevention. The extent to which this recommendation has been implemented globally f...

    Total serum N-glycans associate with response to immune checkpoint inhibition therapy and survival in patients with advanced melanoma

    Publication Type: Academic Journal

    Source(s): BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)

    Abstract: Abstract Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of melanoma and other cancers. However, no reliable biomarker of survival or response has entered the clinic to identify those patients with melanoma who are most...

    Parkin coregulates glutathione metabolism in adult mammalian brain

    Publication Type: Academic Journal

    Source(s): Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)

    Abstract: Abstract We recently discovered that the expression of PRKN, a young-onset Parkinson disease-linked gene, confers redox homeostasis. To further examine the protective effects of parkin in an oxidative stress model, we first combined the loss of prkn wi...

    What is the effect of a low literacy talking book on patient knowledge, anxiety and communication before radiation therapy starts? A pilot study

    Publication Type: Academic Journal

    Source(s): Journal of Medical Radiation Sciences, Vol 69, Iss 4, Pp 463-472 (2022)

    Abstract: Abstract Introduction Radiation therapy is a common cancer treatment, requiring timely information to help patients prepare for treatment. We pilot tested a low literacy, psycho‐educational talking book (written booklet, with accompanying audio recordi...

    Auditory rhythmical cueing to improve gait in community-dwelling stroke survivors (ACTIVATE): a pilot randomised controlled trial

    Publication Type: Academic Journal

    Source(s): Pilot and Feasibility Studies, Vol 8, Iss 1, Pp 1-11 (2022)

    Abstract: Abstract Background Gait impairment limiting mobility and restricting activities is common after stroke. Auditory rhythmical cueing (ARC) uses a metronome beat delivered during exercise to train stepping and early work reports gait improvements. This s...

    Tebentafusp: a first-in-class treatment for metastatic uveal melanoma

    Publication Type: Academic Journal

    Source(s): Therapeutic Advances in Medical Oncology, Vol 15 (2023)

    Abstract: Tebentafusp is a first-in-class immunotherapy agent that comprises an engineered T-cell receptor targeting a gp100 epitope presented by human leukocyte antigen-A*02:01 cells, fused to an anti-CD3 single-chain variable fragment. Tebentafusp is both the ...

    Routine Screening for Central and Primary Adrenal Insufficiency during Immune-Checkpoint Inhibitor Therapy: An Endocrinology Perspective for Oncologists

    Publication Type: Academic Journal

    Source(s): Current Oncology, Vol 29, Iss 370, Pp 4665-4677 (2022)

    Abstract: Background: Immune checkpoint inhibitor (ICI)-associated hypothalamic–pituitary–adrenal axis disruption can lead to hypocortisolism. This is a life-threatening but difficult to diagnose condition, due to its non-specific symptoms that overlap with symp...

    Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

    Publication Type: Academic Journal

    Source(s): The Lancet Global Health, Vol 10, Iss 7, Pp e1003-e1011 (2022)

    Abstract: Summary: Background: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of ...

    Prevalence of skin pressure injury in critical care patients in the UK: results of a single-day point prevalence evaluation in adult critically ill patients

    Publication Type: Academic Journal

    Source(s): BMJ Open, Vol 12, Iss 11 (2022)

    Abstract: Objectives Hospital-acquired pressure injuries (PIs) are a source of morbidity and mortality, and many are potentially preventable.Design This study prospectively evaluated the prevalence and the associated factors of PIs in adult critical care patient...

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