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Platelets and Hemostatic Proteins are Co-Localized with Chronic Neuroinflammation Surrounding Implanted Intracortical Microelectrodes.
Publication Type: Academic Journal
Source(s): Acta biomaterialia [Acta Biomater] 2023 May 19. Date of Electronic Publication: 2023 May 19.
Abstract: Intracortical microelectrodes induce vascular injury upon insertion into the cortex. As blood vessels rupture, blood proteins and blood-derived cells (including platelets) are introduced into the 'immune privileged' brain tissues at higher-than-normal ...
Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect.
Publication Type: Academic Journal
Source(s): Journal of neural engineering [J Neural Eng] 2023 Feb 22; Vol. 20 (1). Date of Electronic Publication: 2023 Feb 22.
Abstract: Electrical stimulation of the cervical vagus nerve using implanted electrodes (VNS) is FDA-approved for the treatment of drug-resistant epilepsy, treatment-resistant depression, and most recently, chronic ischemic stroke rehabilitation. However, VNS is...
Efficacy of bone stimulators in large-animal models and humans may be limited by weak electric fields reaching fracture.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2022 Dec 16; Vol. 12 (1), pp. 21798. Date of Electronic Publication: 2022 Dec 16.
Abstract: Noninvasive electronic bone growth stimulators (EBGSs) have been in clinical use for decades. However, systematic reviews show inconsistent and limited clinical efficacy. Further, noninvasive EBGS studies in small animals, where the stimulation electro...
Assessment of Thermal Damage from Robot-Drilled Craniotomy for Cranial Window Surgery in Mice.
Publication Type: Academic Journal
Source(s): Journal of visualized experiments : JoVE [J Vis Exp] 2022 Nov 11 (189). Date of Electronic Publication: 2022 Nov 11.
Abstract: Cranial window surgery allows for the imaging of brain tissue in live mice with the use of multiphoton or other intravital imaging techniques. However, when performing any craniotomy by hand, there is often thermal damage to brain tissue, which is inhe...
Fascicles split or merge every ∼560 microns within the human cervical vagus nerve.
Publication Type: Academic Journal
Source(s): Journal of neural engineering [J Neural Eng] 2022 Nov 03; Vol. 19 (5). Date of Electronic Publication: 2022 Nov 03.
Abstract: Objective. Vagus nerve stimulation (VNS) is Food and Drug Administration-approved for epilepsy, depression, and obesity, and stroke rehabilitation; however, the morphological anatomy of the vagus nerve targeted by stimulatation is poorly understood. He...
Characterization of a Temporary Peripheral Nerve Stimulation Electrode Utilizing a Bioabsorbable Suture Substrate.
Publication Type: Academic Journal
Source(s): Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2022 Jul; Vol. 2022, pp. 5094-5098.
Abstract: Electrical stimulation after peripheral nerve injury (PNI) has the potential to promote more rapid and complete recovery of damaged fiber tracts. While permanently implanted devices are commonly used to treat chronic or persistent conditions, they are ...
Imaging peripheral nerve micro-anatomy with MUSE, 2D and 3D approaches.
Publication Type: Academic Journal
Source(s): Scientific reports [Sci Rep] 2022 Jun 17; Vol. 12 (1), pp. 10205. Date of Electronic Publication: 2022 Jun 17.
Abstract: Understanding peripheral nerve micro-anatomy can assist in the development of safe and effective neuromodulation devices. However, current approaches for imaging nerve morphology at the fiber level are either cumbersome, require substantial instrumenta...
Tools for Surface Treatment of Silicon Planar Intracortical Microelectrodes.
Publication Type: Academic Journal
Source(s): Journal of visualized experiments : JoVE [J Vis Exp] 2022 Jun 08 (184). Date of Electronic Publication: 2022 Jun 08.
Abstract: Intracortical microelectrodes hold great therapeutic potential. But they are challenged with significant performance reduction after modest implantation durations. A substantial contributor to the observed decline is the damage to the neural tissue pro...
Electrical Stimulation of Acute Fractures: A Narrative Review of Stimulation Protocols and Device Specifications.
Publication Type: Academic Journal
Source(s): Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2022 Jun 02; Vol. 10, pp. 879187. Date of Electronic Publication: 2022 Jun 02 (Print Publication: 2022).
Abstract: Orthopedic fractures have a significant impact on patients in the form of economic loss and functional impairment. Beyond the standard methods of reduction and fixation, one adjunct that has been explored since the late 1970s is electrical stimulation....
Electronic Bone Growth Stimulators for Augmentation of Osteogenesis in In Vitro and In Vivo Models: A Narrative Review of Electrical Stimulation Mechanisms and Device Specifications.
Publication Type: Academic Journal
Source(s): Frontiers in bioengineering and biotechnology [Front Bioeng Biotechnol] 2022 Feb 14; Vol. 10, pp. 793945. Date of Electronic Publication: 2022 Feb 14 (Print Publication: 2022).
Abstract: Since the piezoelectric quality of bone was discovered in 1957, scientists have applied exogenous electrical stimulation for the purpose of healing. Despite the efforts made over the past 60 years, electronic bone growth stimulators are not in common c...