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Advanced Search Results For "Silva, Jeffrey"

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 "Silva, Jeffrey"
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Publication Type: Academic Journal

Source(s): Genome Biology, Vol 23, Iss 1, Pp 1-42 (2022)

Abstract: Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings an...

Gut microbe Lactiplantibacillus plantarum undergoes different evolutionary trajectories between insects and mammals

Publication Type: Academic Journal

Source(s): BMC Biology, Vol 20, Iss 1, Pp 1-24 (2022)

Abstract: Abstract Background Animals form complex symbiotic associations with their gut microbes, whose evolution is determined by an intricate network of host and environmental factors. In many insects, such as Drosophila melanogaster, the microbiome is flexib...

Hepatocyte-derived GDF15 suppresses feeding and improves insulin sensitivity in obese mice

Publication Type: Academic Journal

Source(s): iScience, Vol 25, Iss 12, Pp 105569- (2022)

Abstract: Summary: Growth differentiation factor 15 (GDF15) is a stress-induced secreted protein whose circulating levels are increased in the context of obesity. Recombinant GDF15 reduces body weight and improves glycemia in obese models, which is largely attri...

Longest sediment flows yet measured show how major rivers connect efficiently to deep sea

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Abstract: This paper analyses the longest sediment flows measured in action on Earth. These seabed flows were caused by floods and spring tides, and flushed prodigious sediment and carbon volumes into the deep sea, as they accelerated for a thousand kilometres.


Development of a Nanotechnology Matrix-Based Citronella Oil Insect Repellent to Obtain a Prolonged Effect and Evaluation of the Safety and Efficacy

Publication Type: Academic Journal

Source(s): Life, Vol 13, Iss 141, p 141 (2023)

Abstract: Mosquito-borne diseases affect millions of people worldwide each year, and the use of a topically applied insect repellent is an economically viable preventative health practice. The general objective of this work was to encapsulate citronella oil (CO)...

Identifying the research, advocacy, policy and implementation needs for the prevention and management of respiratory syncytial virus lower respiratory tract infection in low- and middle-income countries

Publication Type: Academic Journal

Source(s): Frontiers in Pediatrics, Vol 10 (2022)

Abstract: IntroductionThe high burden of respiratory syncytial virus (RSV) infection in young children disproportionately occurs in low- and middle-income countries (LMICs). The PROUD (Preventing RespiratOry syncytial virUs in unDerdeveloped countries) Taskforce...

A non-human primate model of acute liver failure suitable for testing liver support systems

Publication Type: Academic Journal

Source(s): Frontiers in Medicine, Vol 9 (2022)

Abstract: Acute hepatic failure is associated with high morbidity and mortality for which the only definitive therapy is liver transplantation. Some fraction of those who undergo emergency transplantation have been shown to recover native liver function when tra...

Clinical-pathologic characteristics and response to neoadjuvant chemotherapy in triple-negative low Ki-67 proliferation (TNLP) breast cancers

Publication Type: Academic Journal

Source(s): npj Breast Cancer, Vol 8, Iss 1, Pp 1-10 (2022)

Abstract: Abstract Triple-negative breast cancers (TNBCs) often have a high Ki-67 proliferation index and respond favorably to neoadjuvant chemotherapy (NACT) with pathologic complete response (pCR) resulting in ~40% of cases. Nevertheless, morbidity/mortality r...

Real-time infection prediction with wearable physiological monitoring and AI to aid military workforce readiness during COVID-19

Publication Type: Academic Journal

Source(s): Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract: Abstract Infectious threats, like the COVID-19 pandemic, hinder maintenance of a productive and healthy workforce. If subtle physiological changes precede overt illness, then proactive isolation and testing can reduce labor force impacts. This study hy...


Impact of COVID-19 Pandemic on Cardiovascular Testing in Asia

Publication Type: Academic Journal

Source(s): JACC: Asia, Vol 1, Iss 2, Pp 187-199 (2021)

Abstract: Background: The coronavirus disease-2019 (COVID-19) pandemic significantly affected management of cardiovascular disease around the world. The effect of the pandemic on volume of cardiovascular diagnostic procedures is not known. Objectives: This study...