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Potential clinical implications of CD4+CD26high T cells for nivolumab treated melanoma patients
Publication Type: Academic Journal
Source(s): Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract: Abstract Background Nivolumab is an anti-PD1 antibody that has dramatically improved metastatic melanoma patients’ outcomes. Nevertheless, many patients are resistant to PD-1 inhibition, occasionally experiencing severe off-target immune toxicity. In a...
Thoracic ultrasound combined with low-dose computed tomography may represent useful screening strategy in highly exposed population in the industrial city of Taranto (Italy)
Publication Type: Academic Journal
Source(s): Frontiers in Medicine, Vol 10 (2023)
Abstract: ObjectivesWe validated a screening protocol in which thoracic ultrasound (TUS) acts as a first-line complementary imaging technique in selecting patients which may deserve a second-line low-dose high resolution computed tomography (HRCT) scan among a p...
IL-6 as new prognostic factor in patients with advanced cutaneous squamous cell carcinoma treated with cemiplimab
Publication Type: Academic Journal
Source(s): Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-6 (2023)
Abstract: Abstract Background Prognostic factors for initial response of advanced cutaneous squamous cell carcinoma to cemiplimab treatment are lacking. Il-6 has been found to affect immune cell populations which impact tumor development. The aim was to investig...
A large series of molecular and serological specimens to evaluate mother-to-child SARS-CoV-2 transmission: a prospective study from the Italian Obstetric Surveillance System
Publication Type: Academic Journal
Source(s): International Journal of Infectious Diseases, Vol 126, Iss , Pp 1-9 (2023)
Abstract: Objectives: To assay the presence of the SARS-CoV-2 genome in vaginal, rectal, and placental swabs among pregnant women and in newborn nasopharyngeal swabs and to investigate the immunological response and maternal antibody transfer through the umbilic...
Concomitant medication of cetirizine in advanced melanoma could enhance anti-PD-1 efficacy by promoting M1 macrophages polarization
Publication Type: Academic Journal
Source(s): Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-11 (2022)
Abstract: Abstract Background The clinical observation showed a potential additive effect of anti-PD-1 agents and cetirizine in patients with advanced melanoma. Methods Clinical outcomes of concomitant cetirizine/anti-PD-1 treatment of patients with stage IIIb–I...
Genetic Mapping of Flavonoid Grain Pigments in Durum Wheat
Publication Type: Academic Journal
Source(s): Plants, Vol 12, Iss 1674, p 1674 (2023)
Abstract: Pigmented cereal grains with high levels of flavonoid compounds have attracted the attention of nutritional science backing the development of functional foods with claimed health benefits. In this study, we report results on the genetic factors contro...
Can Lunar and Martian Soils Support Food Plant Production? Effects of Horse/Swine Monogastric Manure Fertilisation on Regolith Simulants Enzymatic Activity, Nutrient Bioavailability, and Lettuce Growth
Publication Type: Academic Journal
Source(s): Plants, Vol 11, Iss 3345, p 3345 (2022)
Abstract: To make feasible the crewed missions to the Moon or Mars, space research is focusing on the development of bioregenerative life support systems (BLSS) designed to produce food crops based on in situ resource utilisation (ISRU), allowing to reduce terre...
Efficacy and safety of the sofosbuvir/velpatasvir combination for the treatment of patients with early mild to moderate COVID-19
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 12, Iss 1, Pp 1-6 (2022)
Abstract: Abstract SARS-CoV-2 is still a health problem worldwide despite the availability of vaccines. Therefore, there is a need for effective and safe antiviral. SARS-CoV-2 and HCV necessitate RNA-dependent RNA polymerase (RdRp) for replication; therefore, it...
Short-Term Intake of Theobroma grandiflorum Juice Fermented with Lacticaseibacillus rhamnosus ATCC 9595 Amended the Outcome of Endotoxemia Induced by Lipopolysaccharide
Publication Type: Academic Journal
Source(s): Nutrients, Vol 15, Iss 1059, p 1059 (2023)
Abstract: Endotoxemia is a condition caused by increasing levels of lipopolysaccharide (LPS) characterized by an impaired systemic response that causes multiple organ dysfunction. Lacticaseibacillus rhamnosus ATCC 9595 is a strain with probiotic potential which ...
CAR-T-Derived Extracellular Vesicles: A Promising Development of CAR-T Anti-Tumor Therapy
Publication Type: Academic Journal
Source(s): Cancers, Vol 15, Iss 1052, p 1052 (2023)
Abstract: Extracellular vesicles (EVs) are a heterogenous population of plasma membrane-surrounded particles that are released in the extracellular milieu by almost all types of living cells. EVs are key players in intercellular crosstalk, both locally and syste...