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Multivalent in vivo delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escape
Publication Type: Academic Journal
Source(s): Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 249-263 (2023)
Abstract: Glioblastoma multiforme (GBM) is among the most difficult cancers to treat with a 5-year survival rate less than 5%. An immunotherapeutic vaccine approach targeting GBM-specific antigen, EGFRvIII, previously demonstrated important clinical impact. Howe...
DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract: Here, Parzych et al describe the development of a DNA-delivered SARS-CoV-2 mAb cocktail displaying synergistic RBD binding that confers broad neutralizing activity against variants of concern and prophylactic efficacy in multiple small animal models.
Discovery of small molecule inhibitors that effectively disrupt IQGAP1-Cdc42 interaction in breast cancer cells
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract: Abstract The small GTPase Cdc42 is an integral component of the cytoskeleton, and its dysregulation leads to pathophysiological conditions, such as cancer. Binding of Cdc42 to the scaffold protein IQGAP1 stabilizes Cdc42 in its active form. The interac...
Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression in vivo
Publication Type: Academic Journal
Source(s): Frontiers in Immunology, Vol 14 (2023)
Abstract: Cancer immunotherapy has demonstrated great promise with several checkpoint inhibitors being approved as the first-line therapy for some types of cancer, and new engineered cytokines such as Neo2/15 now being evaluated in many studies. In this work, we...
Precipitation-derived effects on the characteristics of proteinaceous soil organic matter across the continental United States
Publication Type: Academic Journal
Source(s): Frontiers in Soil Science, Vol 2 (2022)
Abstract: Proteinaceous amino acids composed up to 50% of microbial biomass, are a primary building block of soil organic nitrogen, and play a key role in soil organic N and C cycling. However, the large-scale drivers on these organic nitrogen pools is less expl...
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract: Sarcomas are rare tumours with many different subtypes and clinical outcomes; a broader knowledge of their genetic features is required. Here, the authors analyse 2138 soft tissue and bone sarcomas across 45 subtypes using MSK-IMPACT targeted sequencin...
(9R,9aS,12aR,13S)-9,13-Diphenyl-9,9a,12a,13-tetrahydro-9,13-methanotriphenyleno[2,3-c]furan-10,12,14-trione
Publication Type: Academic Journal
Source(s): Molbank, Vol 2022, Iss M1435, p M1435 (2022)
Abstract: X-ray crystallography was used to characterise the title compound for the first time, and the 1H NMR, 13C NMR and IR spectroscopic data from earlier reports were also updated.
Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules
Publication Type: Academic Journal
Source(s): Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 335-348 (2022)
Abstract: A functional cure of chronic hepatitis B requires eliminating the hepatitis B virus (HBV)-encoded surface antigen (HBsAg), which can suppress immune responses. STOPS are phosphorothioated single-stranded oligonucleotides containing novel chemistries th...
Shared antibiotic resistance and virulence genes in Staphylococcus aureus from diverse animal hosts
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract: Abstract The emergence of methicillin-resistant Staphylococcus aureus (MRSA) poses an important threat in human and animal health. In this study, we ask whether resistance and virulence genes in S. aureus are homogeneously distributed or constrained by...
Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract: HIV envelope is a target for vaccine development, but induction of broadly neutralizing antibodies has been difficult. Here, the authors show that electroporation with a synthetic DNA vaccine construct allows in vivo production of HIV envelope native l...