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Dolutegravir potentiates platelet activation by a calcium-dependent, ionophore-like mechanism
Publication Type: Academic Journal
Source(s): Journal of Immunotoxicology, Vol 19, Iss 1, Pp 1-8 (2022)
Abstract: Dolutegravir is a highly potent HIV integrase strand transfer inhibitor that is recommended for first-line anti-retroviral treatment in all major treatment guidelines. A recent study has shown that people taking this class of anti-retroviral treatment ...
Assessment of the efficacy of clofazimine alone and in combination with primary agents against Mycobacterium tuberculosis in vitro
Publication Type: Academic Journal
Source(s): Journal of Global Antimicrobial Resistance, Vol 29, Iss , Pp 343-352 (2022)
Abstract: ABSTRACT: Objectives: The chemotherapeutic regimens of patients with drug-susceptible (DS)- tuberculosis (TB) comprise four primary anti-TB drugs: rifampicin (RMP), isoniazid (INH), ethambutol (EMB) and pyrazinamide (PZA), administered for six-to-nine ...
Systemic levels of the soluble co-inhibitory immune checkpoints, CTLA-4, LAG-3, PD-1/PD-L1 and TIM-3 are markedly increased in basal cell carcinoma
Publication Type: Academic Journal
Source(s): Translational Oncology, Vol 19, Iss , Pp 101384- (2022)
Abstract: Although co-inhibitory immune checkpoint proteins are primarily involved in promoting cell-cell interactions that suppress adaptive immunity, especially tumor immunity, the soluble cell-free variants of these molecules are also detectable in the circul...
Systemic Immune Dysregulation in Early Breast Cancer Is Associated With Decreased Plasma Levels of Both Soluble Co-Inhibitory and Co-Stimulatory Immune Checkpoint Molecules
Publication Type: Academic Journal
Source(s): Frontiers in Immunology, Vol 13 (2022)
Abstract: Breast cancer cells exploit the up-regulation or down-regulation of immune checkpoint proteins to evade anti-tumor immune responses. To explore the possible involvement of this mechanism in promoting systemic immunosuppression, the pre-treatment levels...
Elevated Levels of Soluble CTLA-4, PD-1, PD-L1, LAG-3 and TIM-3 and Systemic Inflammatory Stress as Potential Contributors to Immune Suppression and Generalized Tumorigenesis in a Cohort of South African Xeroderma Pigmentosum Patients
Publication Type: Academic Journal
Source(s): Frontiers in Oncology, Vol 12 (2022)
Abstract: Xeroderma Pigmentosum (XP), an autosomal recessive disorder characterized by ultraviolet radiation-induced abnormalities of DNA excision and repair pathways is associated with early development of cutaneous cancers. Intracellular oxidative stress has a...
Experimental Study on the Development Characteristics and Controlling Factors of Microscopic Organic Matter Pore and Fracture System in Shale
Publication Type: Academic Journal
Source(s): Frontiers in Earth Science, Vol 9 (2021)
Abstract: Research on microscopic pore and fracture system of shale is a hot spot in the field of unconventional petroleum geology. Micro- and nano-scale organic matter pores in shale play a vital role in the accumulation of hydrocarbons. Research on the types, ...
Interactions of HIV and Antiretroviral Therapy With Neutrophils and Platelets
Publication Type: Academic Journal
Source(s): Frontiers in Immunology, Vol 12 (2021)
Abstract: Neutrophils are important components of the innate immune system that mediate pathogen defense by multiple processes including phagocytosis, release of proteolytic enzymes, production of reactive oxygen species, and neutrophil extracellular trap format...
Submission for Special Issue: The Role of Platelet Activation in the Pathophysiology of HIV, Tuberculosis, and Pneumococcal Disease. Bedaquiline Suppresses ADP-Mediated Activation of Human Platelets In Vitro via Interference With Phosphatidylinositol 3-Kinase
Publication Type: Academic Journal
Source(s): Frontiers in Immunology, Vol 11 (2021)
Abstract: Although bedaquiline has advanced the treatment of multidrug-resistant tuberculosis (TB), concerns remain about the cardiotoxic potential of this agent, albeit by unexplored mechanisms. Accordingly, we have investigated augmentation of the reactivity o...
Differential Responsiveness of the Platelet Biomarkers, Systemic CD40 Ligand, CD62P, and Platelet-Derived Growth Factor-BB, to Virally-Suppressive Antiretroviral Therapy
Publication Type: Academic Journal
Source(s): Frontiers in Immunology, Vol 11 (2021)
Abstract: Systemic biomarkers of inflammation, including cytokines and chemokines, are potentially useful in the management of both HIV infection and non-AIDS-defining disorders. However, relatively little is known about the utility of measurement of circulating...
754 Dysregulation of soluble immune checkpoint proteins in newly – diagnosed early breast cancer patients
Publication Type: Academic Journal
Source(s): Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)