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Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract: Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well as ...
Origin and Emergence of Microglia in the CNS—An Interesting (Hi)story of an Eccentric Cell
Publication Type: Academic Journal
Source(s): Current Issues in Molecular Biology, Vol 45, Iss 171, Pp 2609-2628 (2023)
Abstract: Microglia belong to tissue-resident macrophages of the central nervous system (CNS), representing the primary innate immune cells. This cell type constitutes ~7% of non-neuronal cells in the mammalian brain and has a variety of biological roles integra...
Linking movement and dive data to prey distribution models: new insights in foraging behaviour and potential pitfalls of movement analyses
Publication Type: Academic Journal
Source(s): Movement Ecology, Vol 11, Iss 1, Pp 1-14 (2023)
Abstract: Abstract Background Animal movement data are regularly used to infer foraging behaviour and relationships to environmental characteristics, often to help identify critical habitat. To characterize foraging, movement models make a set of assumptions roo...
MALT1-dependent cleavage of CYLD promotes NF-κB signaling and growth of aggressive B-cell receptor-dependent lymphomas
Publication Type: Academic Journal
Source(s): Blood Cancer Journal, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract: Abstract The paracaspase mucosa-associated lymphoid tissue 1 (MALT1) is a protease and scaffold protein essential in propagating B-cell receptor (BCR) signaling to NF-κB. The deubiquitinating enzyme cylindromatosis (CYLD) is a recently discovered MALT1...
The CONFIDENT study protocol: a randomized controlled trial comparing two methods to increase long-term care worker confidence in the COVID-19 vaccines
Publication Type: Academic Journal
Source(s): BMC Public Health, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract: Abstract Background Clinical and real-world effectiveness data for the COVID-19 vaccines have shown that they are the best defense in preventing severe illness and death throughout the pandemic. However, in the US, some groups remain more hesitant than...
Cost Savings of Expedited Care with Upfront Next-Generation Sequencing Testing versus Single-Gene Testing among Patients with Metastatic Non-Small Cell Lung Cancer Based on Current Canadian Practices
Publication Type: Academic Journal
Source(s): Current Oncology, Vol 30, Iss 180, Pp 2348-2365 (2023)
Abstract: This study assessed the total costs of testing, including the estimated costs of delaying care, associated with next-generation sequencing (NGS) versus single-gene testing strategies among patients with newly diagnosed metastatic non-small cell lung ca...
Occupational demands associated with rotator cuff disease surgery in the UK Biobank
Publication Type: Academic Journal
Source(s): Scandinavian Journal of Work, Environment & Health, Vol 49, Iss 1, Pp 53-63 (2023)
Abstract: OBJECTIVES: Physically-demanding occupations may increase rotator cuff disease (RCD) risk and need for surgery. We linked a job-exposure matrix (JEM) to the UK Biobank cohort study to measure physical occupational exposures and estimate associations wi...
Leveraging PEPFAR-Supported Health Information Systems for COVID-19 Pandemic Response
Publication Type: Academic Journal
Source(s): Emerging Infectious Diseases, Vol 28, Iss 13, Pp 49-58 (2022)
Abstract: Since 2003, the US President’s Emergency Plan for AIDS Relief (PEPFAR) has supported implementation and maintenance of health information systems for HIV/AIDS and related diseases, such as tuberculosis, in numerous countries. As the COVID-19 pandemic e...
Theory, phenomenology, and experimental avenues for dark showers: a Snowmass 2021 report
Publication Type: Academic Journal
Source(s): European Physical Journal C: Particles and Fields, Vol 82, Iss 12, Pp 1-66 (2022)
Abstract: Abstract In this work, we consider the case of a strongly coupled dark/hidden sector, which extends the Standard Model (SM) by adding an additional non-Abelian gauge group. These extensions generally contain matter fields, much like the SM quarks, and ...
Clinical presentation, outcome, and prognostic markers in patients with intravascular large B‐cell lymphoma, a lymphoma study association (LYSA) retrospective study
Publication Type: Academic Journal
Source(s): Cancer Medicine, Vol 11, Iss 19, Pp 3602-3611 (2022)
Abstract: Abstract Background Intravascular large B‐cell lymphoma (lVLBCL) is a very rare type of large B‐cell lymphoma. Methods We conducted a retrospective study on IVLBCL patients treated from 2000 to 2016 in LYSA cooperative group centers. Results Sixty‐five...