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    • Loss of the Bardet-Biedl protein Bbs1 alters photoreceptor outer segment protein and lipid composition

    Publication Type: Academic Journal

    Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

    Abstract: Primary cilia are key sensory organelles whose dysfunction leads to ciliopathy disorders such as Bardet-Biedl syndrome (BBS). Here they identify a role for Bbs1 in lipid homeostasis of photoreceptor outer segments in zebrafish, which may contribute to ...

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    Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma

    Publication Type: Academic Journal

    Source(s): Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

    Abstract: Astrocytes play important roles in neuroinflammatory diseases. Here the authors characterize human glioblastoma-associated astrocytes by gene expression and demonstrate their immunosuppressive role promoted by interactions with tumor and microglia cell...

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    Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves.

    Publication Type: Academic Journal

    Source(s): PLoS Genetics, Vol 16, Iss 6, p e1008774 (2020)

    Abstract: Cranial neural crest (NC) contributes to the developing vertebrate eye. By multidimensional, quantitative imaging, we traced the origin of the ocular NC cells to two distinct NC populations that differ in the maintenance of sox10 expression, Wnt signal...

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    EmbryoMiner: A new framework for interactive knowledge discovery in large-scale cell tracking data of developing embryos.

    Publication Type: Academic Journal

    Source(s): PLoS Computational Biology, Vol 14, Iss 4, p e1006128 (2018)

    Abstract: State-of-the-art light-sheet and confocal microscopes allow recording of entire embryos in 3D and over time (3D+t) for many hours. Fluorescently labeled structures can be segmented and tracked automatically in these terabyte-scale 3D+t images, resultin...

    Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer

    Publication Type: Academic Journal

    Source(s): eLife, Vol 6 (2017)

    Abstract: Targeting the activation function-1 (AF-1) domain located in the N-terminus of the androgen receptor (AR) is an attractive therapeutic alternative to the current approaches to inhibit AR action in prostate cancer (PCa). Here we show that the AR AF-1 is...

    Impacts of different exposure scenarios on transcript abundances in Danio rerio embryos when investigating the toxicological burden of riverine sediments.

    Publication Type: Academic Journal

    Source(s): PLoS ONE, Vol 9, Iss 9, p e106523 (2014)

    Abstract: PURPOSE: Recently, a proof-of-concept study revealed the suitability of transcriptome analyses to obtain and assess changes in the abundance of transcripts in zebrafish (Danio rerio) embryos after exposure to organic sediment extracts. The present stud...

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    Fast segmentation of stained nuclei in terabyte-scale, time resolved 3D microscopy image stacks.

    Publication Type: Academic Journal

    Source(s): PLoS ONE, Vol 9, Iss 2, p e90036 (2014)

    Abstract: Automated analysis of multi-dimensional microscopy images has become an integral part of modern research in life science. Most available algorithms that provide sufficient segmentation quality, however, are infeasible for a large amount of data due to ...

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    Funduscopy in adult zebrafish and its application to isolate mutant strains with ocular defects.

    Publication Type: Academic Journal

    Source(s): PLoS ONE, Vol 5, Iss 11, p e15427 (2010)

    Abstract: Funduscopy is one of the most commonly used diagnostic tools in the ophthalmic practice, allowing for a ready assessment of pathological changes in the retinal vasculature and the outer retina. This non-invasive technique has so far been rarely used in...

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    Crystal structure of E-4-(2'-ethoxycarbonyl-2'-methyl)-ethenyl-[2.2]paracyclophane, C22H24O2

    Publication Type: Academic Journal

    Source(s): Zeitschrift für Kristallographie - New Crystal Structures, Vol 212, Iss 1, Pp 271-272 (1997)

    Crystal structure of bis(biphenyl)chromium(I)iodide chloroform solvate, [(C12H10)2CrI] CHCl3

    Publication Type: Academic Journal

    Source(s): Zeitschrift für Kristallographie - New Crystal Structures, Vol 212, Iss 1, Pp 269-270 (1997)

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