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Advanced Search Results For "Tang, Puay"

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 "Tang, Puay"
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Publication Type: Academic Journal

Source(s): Genome Biology, Vol 23, Iss 1, Pp 1-42 (2022)

Abstract: Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings an...

Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models: implications for risk stratification

Publication Type: Academic Journal

Source(s): BMC Medicine, Vol 20, Iss 1, Pp 1-11 (2022)

Abstract: Abstract Background Family history, and genetic and non-genetic risk factors can stratify women according to their individual risk of developing breast cancer. The extent of overlap between these risk predictors is not clear. Methods In this case-only ...

Diabetes and other vascular risk factors in association with the risk of lower extremity amputation in chronic limb-threatening ischemia: a prospective cohort study

Publication Type: Academic Journal

Source(s): Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-9 (2022)

Abstract: Abstract Background Patients with diabetes are at increased risk of developing chronic limb-threatening ischemia (CLTI) due to peripheral arterial disease, and this often results in lower extremity amputation (LEA). Little is known of the interaction b...

Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Abstract: BRD4 has a pro-tumorigenic role but non-cell-autonomous mechanisms of BRD4 activation need to be elucidated. Here the authors unravel a mechanism by which CAFs activate BRD4 and induce resistance to BET inhibitors in cancer cells through IL6/IL8 signal...

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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Abstract: GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of f...

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Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)

Abstract: The chromosome 15q25.1 locus is a leading susceptibility region for lung cancer. Here, the authors interrogate three GWAS cohorts with 42,901 individuals to investigate potential pathological pathways such as gated channel activity and neuroactive liga...

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Association between educational level and total and cause-specific mortality: a pooled analysis of over 694 000 individuals in the Asia Cohort Consortium

Publication Type: Academic Journal

Source(s): BMJ Open, Vol 9, Iss 8 (2019)

Abstract: ObjectiveTo study the association of educational level and risk of death from all causes, cardiovascular disease (CVD) and cancer among Asian populations.DesignA pooled analysis of 15 population-based cohort studies.Setting and participants694 434 Asia...

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Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)

Abstract: It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosom...

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Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

Publication Type: Academic Journal

Source(s): PLoS ONE, Vol 13, Iss 6, p e0198166 (2018)

Abstract: Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol...

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A prospective evaluation of serum kynurenine metabolites and risk of pancreatic cancer.

Publication Type: Academic Journal

Source(s): PLoS ONE, Vol 13, Iss 5, p e0196465 (2018)

Abstract: Serum pyridoxal 5'-phosphate (PLP), the active form of vitamin B6, is associated with reduced risk of pancreatic cancer. Data on functional measures of vitamin B6 status and risk of pancreatic cancer is lacking.A nested case-control study involving 187...

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