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Advanced Search Results For "Thomas W. Winkler"

1 - 10 of 628 results for
 "Thomas W. Winkler"
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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Publication Type: Academic Journal

Source(s): Communications Biology, Vol 5, Iss 1, Pp 1-20 (2022)

Abstract: A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.

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Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Abstract: Identifying causal variants and genes in genome-wide association studies remains a challenge, an issue that is ameliorated with larger sample sizes. Here the authors meta-analyze kidney function genome-wide association studies to identify new loci and ...

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Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease

Publication Type: Academic Journal

Source(s): BMC Medical Genomics, Vol 13, Iss 1, Pp 1-18 (2020)

Abstract: Abstract Background Advanced age-related macular degeneration (AMD) is a leading cause of blindness. While around half of the genetic contribution to advanced AMD has been uncovered, little is known about the genetic architecture of early AMD. Methods ...

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Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

Publication Type: Academic Journal

Source(s): HGG Advances, Vol 2, Iss 1, Pp 100013- (2021)

Abstract: Summary: Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic...

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Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Abstract: Sleep duration is associated with an adverse lipid profile. Here, the authors perform genome-wide gene-by-sleep interaction analysis and find 49 previously unreported lipid loci when considering short or long total sleep time.

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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Abstract: GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of f...

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GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Abstract: Carotid intima-media thickness (cIMT) and plaque are associated with subclinical atherosclerosis and coronary heart disease (CHD). Here, the authors identify and prioritize genetic loci for cIMT and plaque by GWAS and colocalization approaches and furt...

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The role of genetic variation of human metabolism for BMI, mental traits and mental disorders

Publication Type: Academic Journal

Source(s): Molecular Metabolism, Vol 12, Iss , Pp 1-11 (2018)

Abstract: Objective: The aim was to assess whether loci associated with metabolic traits also have a significant role in BMI and mental traits/disorders Methods: We first assessed the number of single nucleotide polymorphisms (SNPs) with genome-wide significance...

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CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

Abstract: Individual SNPs have small effects on anthropometric traits, yet the impact of CNVs has remained largely unknown. Here, Kutalik and co-workers perform a large-scale genome-wide meta-analysis of structural variation and find rare CNVs associated with he...

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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)

Abstract: Genome-wide association studies (GWAS) have become a key tool to discover genetic markers for complex traits; however, environmental factors that interact with genes are rarely considered. Here, the authors conduct a GWAS of obesity traits, and find th...

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