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Advanced Search Results For "Timokratis Karamitros"

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 "Timokratis Karamitros"
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Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement of deleterious mutations

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)

Abstract: Helicobacter pylori is a major human pathogen whose population structure is similar to that of its host. Here, the authors show that H. pylori has repeatedly spread out of Africa recently, replacing deleterious variants that accumulated during the orig...

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Tracing the First Days of the SARS-CoV-2 Pandemic in Greece and the Role of the First Imported Group of Travelers

Publication Type: Academic Journal

Source(s): Microbiology Spectrum, Vol 10, Iss 6 (2022)

Abstract: ABSTRACT The first SARS-CoV-2 case in Greece was confirmed on February 26, 2020, and since then, multiple strains have circulated the country, leading to regional and country-wide outbreaks. Our aim is to enlighten the events that took place during the...

Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson’s Disease

Publication Type: Academic Journal

Source(s): Biomolecules, Vol 12, Iss 876, p 876 (2022)

Abstract: Parkinson’s disease (PD) is the second most common neurodegenerative disorder, classically associated with extensive loss of dopaminergic neurons of the substantia nigra pars compacta. The hallmark of the disease is the accumulation of pathogenic confo...

Targeted Virome Sequencing Enhances Unbiased Detection and Genome Assembly of Known and Emerging Viruses—The Example of SARS-CoV-2

Publication Type: Academic Journal

Source(s): Viruses, Vol 14, Iss 1272, p 1272 (2022)

Abstract: Targeted virome enrichment and sequencing (VirCapSeq-VERT) utilizes a pool of oligos (baits) to enrich all known—up to 2015—vertebrate-infecting viruses, increasing their detection sensitivity. The hybridisation of the baits to the target sequences can...

Upregulation of Human Endogenous Retroviruses in Bronchoalveolar Lavage Fluid of COVID-19 Patients

Publication Type: Academic Journal

Source(s): Microbiology Spectrum, Vol 9, Iss 2 (2021)

Abstract: ABSTRACT Severe COVID-19 pneumonia has been associated with the development of intense inflammatory responses during the course of infections with SARS-CoV-2. Given that human endogenous retroviruses (HERVs) are known to be activated during and partici...

Molecular and Clinical Prognostic Biomarkers of COVID-19 Severity and Persistence

Publication Type: Academic Journal

Source(s): Pathogens, Vol 11, Iss 311, p 311 (2022)

Abstract: The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), poses several challenges to clinicians, due to its unpredictable clinical course. The identification of laboratory biomarkers, specific...

Hepatitis B Virus Integration into Transcriptionally Active Loci and HBV-Associated Hepatocellular Carcinoma

Publication Type: Academic Journal

Source(s): Microorganisms, Vol 10, Iss 253, p 253 (2022)

Abstract: Hepatitis B Virus (HBV) DNA integrations into the human genome are considered major causative factors to HBV-associated hepatocellular carcinoma development. In the present study, we investigated whether HBV preferentially integrates parts of its genom...

Hepatitis B Virus DNA Integration, Chronic Infections and Hepatocellular Carcinoma

Publication Type: Academic Journal

Source(s): Microorganisms, Vol 9, Iss 1787, p 1787 (2021)

Abstract: Hepatitis B Virus (HBV) is an Old World virus with a high mutation rate, which puts its origins in Africa alongside the origins of Homo sapiens, and is a member of the Hepadnaviridae family that is characterized by a unique viral replication cycle. It ...

Dual RNA-Seq Enables Full-Genome Assembly of Measles Virus and Characterization of Host–Pathogen Interactions

Publication Type: Academic Journal

Source(s): Microorganisms, Vol 9, Iss 1538, p 1538 (2021)

Abstract: Measles virus (MeV) has a negative-sense 15 kb long RNA genome, which is generally conserved. Recent advances in high-throughput sequencing (HTS) and Dual RNA-seq allow the analysis of viral RNA genomes and the discovery of viral infection biomarkers, ...

Nanopore sequencing and full genome de novo assembly of human cytomegalovirus TB40/E reveals clonal diversity and structural variations

Publication Type: Academic Journal

Source(s): BMC Genomics, Vol 19, Iss 1, Pp 1-12 (2018)

Abstract: Abstract Background Human cytomegalovirus (HCMV) has a double-stranded DNA genome of approximately 235 Kbp that is structurally complex including extended GC-rich repeated regions. Genomic recombination events are frequent in HCMV cultures but have als...

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