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Advanced Search Results For "Toolan N"

1 - 10 of 39 results for
 "Toolan N"
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A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy

Publication Type:Academic Journal

Source(s):Neurobiology of Disease, Vol 159, Iss , Pp 105507- (2021)

Abstract:Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD). GCase metabolizes the glycosphingolipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSph)...

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Intracranial administration of alpha-synuclein fibrils in A30P-synuclein transgenic mice causes robust synucleinopathy and microglial induction.

Publication Type:Academic Journal

Source(s):Neurobiology of Aging. Oct2021, Vol. 106, p12-25. 14p.

Abstract:Synucleinopathies are neurodegenerative disorders involving pathological alpha-synuclein (αSyn) protein, including dementia with Lewy bodies, multiple system atrophy and Parkinson's disease (PD). Current in vivo models of synucleinopathy include transg...

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Comparison of Perioperative Complications and Hospitalization Outcomes After Ankle Arthrodesis Versus Total Ankle Arthroplasty From 2002 to 2011.

Publication Type:Academic Journal

Source(s):Foot & Ankle International; Apr2015, Vol. 36 Issue 4, p360-368, 9p

Abstract:The article discusses a study which aimed to compare the perioperative complications and hospitalization outcomes after ankle arthrodesis (AAD) versus ankle arthroplasty (TAA). Topics covered include a comparison of the demographics, comorbidities, and...

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Effect of Diabetes Mellitus on Perioperative Complications and Hospital Outcomes After Ankle Arthrodesis and Total Ankle Arthroplasty.

Publication Type:Academic Journal

Source(s):Foot & Ankle International; Mar2015, Vol. 36 Issue 3, p258-267, 10p

Abstract:Copyright of Foot & Ankle International is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print...

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Mining web logs for personalized site maps.

Publication Type:Conference

Source(s):Proceedings of the Third International Conference on Web Information Systems Engineering (Workshops), 2002; 2002, p232-237, 6p

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High Throughput Monitoring of Amyloid-β42 Assembly into Soluble Oligomers Achieved by Sensitive Conformation State-Dependent Immunoassays.

Publication Type:Academic Journal

Source(s):Journal of Alzheimer's Disease; 2011, Vol. 25 Issue 4, p655-669, 15p, 1 Color Photograph, 1 Diagram, 4 Graphs

Abstract:Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, downloa...

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Bovine and ovine rumen fluke in Ireland—Prevalence, risk factors and species identity based on passive veterinary surveillance and abattoir findings.

Publication Type:Academic Journal

Source(s):Veterinary Parasitology. Sep2015, Vol. 212 Issue 3/4, p168-174. 7p.

Abstract:The prevalence of rumen fluke, the incidence of clinical paramphistomosis and the trematode’s species identity were studied in cattle and sheep in the Republic of Ireland using passive veterinary surveillance (faecal examination and necropsy results; 2...

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Growth and Cytopathogenicity of H-viruses in Human and Simian Cell Cultures.

Publication Type:Academic Journal

Source(s):Nature; 11/20/1965, Vol. 208 Issue 5012, p812-813, 2p

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A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy.

Publication Type:Academic Journal

Source(s):Neurobiology of Disease. Nov2021, Vol. 159, pN.PAG-N.PAG. 1p.

Abstract:Mutations in the lysosomal enzyme glucocerebrosidase (GCase, GBA1 gene) are the most common genetic risk factor for developing Parkinson's disease (PD). GCase metabolizes the glycosphingolipids glucosylceramide (GlcCer) and glucosylsphingosine (GlcSph)...

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Legal implications of the climate-health crisis: A case study analysis of the role of public health in climate litigation.

Publication Type:Academic Journal

Source(s):PloS one [PLoS One] 2022 Jun 15; Vol. 17 (6), pp. e0268633. Date of Electronic Publication: 2022 Jun 15 (Print Publication: 2022).

Abstract:Background: Strong scientific evidence affirms that climate change is now a public health emergency. Increasingly, climate litigation brought against governments and corporations utilizes international human rights, environmental and climate laws and p...

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