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Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening.
Publication Type: Academic Journal
Source(s): Stem cell research [Stem Cell Res] 2022 Apr; Vol. 60, pp. 102673. Date of Electronic Publication: 2022 Jan 19.
Abstract: In this paper, we describe the generation and validation of human induced pluripotent stem cell (hiPSC) lines from peripheral blood mononuclear cells (PBMCs) from 6 epilepsy patients using a non-integrative Sendai virus vector. These human cellular mod...
Generation of induced pluripotent stem cell lines from peripheral blood mononuclear cells of three drug resistant and three drug responsive epilepsy patients.
Publication Type: Academic Journal
Source(s): Stem cell research [Stem Cell Res] 2021 Oct; Vol. 56, pp. 102564. Date of Electronic Publication: 2021 Oct 09.
Abstract: Epilepsy is a common neurological disorder characterized by seizures. Unfortunately, 30-40% of all epilepsy patients are resistant to at least two or more anti-seizure medications. Attempts to treat these patients and prevent further seizures necessita...
A strategic review on the involvement of receptors, transcription factors and hormones in acne pathogenesis.
Publication Type: Academic Journal
Source(s): Journal of receptor and signal transduction research [J Recept Signal Transduct Res] 2021 Apr; Vol. 41 (2), pp. 105-116. Date of Electronic Publication: 2020 Aug 13.
Abstract: Acne vulgaris is a very common pilosebaceous inflammatory disease occurring primarily on the face and also rare on the upper arms, trunk, and back, which is caused by Propionibacterium, Staphylococcus, Corynebacterium , and other species. Pathophysiolo...
Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis.
Publication Type: Academic Journal
Source(s): Cancer research [Cancer Res] 2018 Feb 01; Vol. 78 (3), pp. 671-684. Date of Electronic Publication: 2017 Dec 06.
Abstract: Resistance to cancer treatment can be driven by epigenetic reprogramming of specific transcriptomes in favor of the refractory phenotypes. Here we discover that tamoxifen resistance in breast cancer is driven by a regulatory axis consisting of a master...
Process, Physicochemical Characterization and In-Vitro Assessment of Albendazole Microcrystals.
Publication Type: Academic Journal
Source(s): Advanced pharmaceutical bulletin [Adv Pharm Bull] 2017 Sep; Vol. 7 (3), pp. 419-425. Date of Electronic Publication: 2017 Sep 25.
Abstract: Purpose: Albendazole is a poorly soluble drug which limits its oral bioavailability. The study was focussed to enhance the solubility by in-situ micronization. Methods: Albendazole microcrystals were prepared by solvent ch...
In vitro characterization studies of self-microemulsified bosentan systems.
Publication Type: Academic Journal
Source(s): Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2017 Jun; Vol. 43 (6), pp. 989-995. Date of Electronic Publication: 2017 Feb 16.
Abstract: Context: Bosentan is a poorly soluble drug and pose challenges in designing of drug delivery systems.Objective: The objective of this study is to enhance the solubility, dissolution and shelf-life of bosentan by formulating it as S-SMEDDS capsules.Mate...
Chronopharmacokinetic Evaluation of Budesonide Multiparticulate Systems.
Publication Type: Academic Journal
Source(s): Recent patents on drug delivery & formulation [Recent Pat Drug Deliv Formul] 2017; Vol. 11 (3), pp. 221-229.
Abstract: Background: Poor oral absorption of budesonide limits the design of its solid oral dosage form. With this context, multiparticulate pulsatile system of budesonide for chronotherapy of nocturnal asthma was aimed in this study.Methods: Initially, solid d...
Insecticidal activity of a novel fatty acid amide derivative from Streptomyces species against Helicoverpa armigera.
Publication Type: Academic Journal
Source(s): Natural product research [Nat Prod Res] 2016 Dec; Vol. 30 (24), pp. 2760-2769. Date of Electronic Publication: 2016 Mar 08.
Abstract: Helicoverpa armigera, an important pest causes serious damage to grain legumes. The main objective of this study was to isolate and identify the metabolite against H. armigera from a previously characterised Streptomyces sp. CAI-155. The culture filtra...
Tyrosine phosphorylation regulates ERβ ubiquitination, protein turnover, and inhibition of breast cancer.
Publication Type: Academic Journal
Source(s): Oncotarget [Oncotarget] 2016 Jul 05; Vol. 7 (27), pp. 42585-42597.
Abstract: Unlike estrogen receptor α (ERα) that predominantly promotes hormone-dependent breast tumor growth, ERβ exhibits antitumor effects in a variety of cancer types. We recently identified a phosphotyrosine residue in ERβ, but not ERα, that dictates ERβ tra...
Solid self microemulsification of Atorvastatin using hydrophilic carriers: a design.
Publication Type: Academic Journal
Source(s): Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2015; Vol. 41 (7), pp. 1213-22. Date of Electronic Publication: 2014 Jul 14.
Abstract: Context: Atorvastatin has a limited advantage to formulate oral dosage forms.Objective: To enhance the solubility of Atorvastatin and to design the suitable solid self-microemulsifying drug delivery systems (S-SMEDDS) Materials and methods: The clear a...