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Protective effect of short-term thymoquinone administration on the central nervous system in cisplatin-induced neurotoxicity
Publication Type: Academic Journal
Source(s): European Review for Medical and Pharmacological Sciences, Vol 26 (2022)
Abstract: OBJECTIVE: This study was performed to investigate the potential beneficial effects of thymoquinone (TQ) on brain tissue based on biochemical and histopathological analyses in cisplatin (CIS) treated rats with central nervous system (CNS) neurotoxicity...
Proteomics analysis of a human brain sample from a mucolipidosis type IV patient reveals pathophysiological pathways
Publication Type: Academic Journal
Source(s): Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-13 (2021)
Abstract: Abstract Background Mucolipidosis type IV (MLIV), an ultra-rare neurodevelopmental and neurodegenerative disorder, is caused by mutations in the MCOLN1 gene, which encodes the late endosomal/lysosomal transient receptor potential channel TRPML1 (mucoli...
Mice defective in interferon signaling help distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease
Publication Type: Academic Journal
Source(s): Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-13 (2020)
Abstract: Abstract Background The type 1 interferon (IFN) response is part of the innate immune response and best known for its role in viral and bacterial infection. However, this pathway is also induced in sterile inflammation such as that which occurs in a nu...
Immunity onset alters plant chromatin and utilizes EDA16 to regulate oxidative homeostasis.
Publication Type: Academic Journal
Source(s): PLoS Pathogens, Vol 17, Iss 5, p e1009572 (2021)
Abstract: Perception of microbes by plants leads to dynamic reprogramming of the transcriptome, which is essential for plant health. The appropriate amplitude of this transcriptional response can be regulated at multiple levels, including chromatin. However, the...
Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease
Publication Type: Academic Journal
Source(s): Neurobiology of Disease, Vol 127, Iss , Pp 563-569 (2019)
Abstract: Bi-allelic mutations in the glucocerebrosidase gene (GBA1) cause Gaucher's disease, the most common human lysosomal storage disease. We previously reported a marked increase in miR-155 transcript levels and early microglial activation in a zebrafish mo...
Light-dependent single-cell heterogeneity in the chloroplast redox state regulates cell fate in a marine diatom
Publication Type: Academic Journal
Source(s): eLife, Vol 8 (2019)
Abstract: Diatoms are photosynthetic microorganisms of great ecological and biogeochemical importance, forming vast blooms in aquatic ecosystems. However, we are still lacking fundamental understanding of how individual cells sense and respond to diverse stress ...
Magnesium-Rich Nanometric Layer in the Skeleton of Pocillopora damicornis With Possible Involvement in Fibrous Aragonite Deposition
Publication Type: Academic Journal
Source(s): Frontiers in Marine Science, Vol 5 (2018)
Abstract: The complex structures and morphologies of coral skeletons make it difficult to study the construction of individual skeleton components. This is especially true regarding micro-structures deposited during different stages of skeletogenesis. As such st...
A coral-on-a-chip microfluidic platform enabling live-imaging microscopy of reef-building corals
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Abstract: Studies of coral in laboratory settings are limited by a lack of reliable methods for manipulation of the coral microenvironment and monitoring of coral processes in vitro. Here the authors develop coral-on-a-chip, a microfluidic platform to enable stu...
Evaluation of the cardiovascular effects of varenicline in rats
Publication Type: Academic Journal
Source(s): Drug Design, Development and Therapy, Vol 2015, Iss default, Pp 5705-5717 (2015)
Abstract: Engin Burak Selçuk,1 Meltem Sungu,2 Hakan Parlakpinar,3 Necip Ermiş,4 Elif Taslıdere,5 Nigar Vardı,5 Murat Yalçinsoy,6 Mustafa Sagır,3 Alaaddin Polat,7 Mehmet Karatas,8 Burcu Kayhan-Tetik11Department of Family Medicine, 2Inonu University Medical Facult...
Coping strategies, satisfaction with life, and quality of life in Crohn's disease: A gender perspective using structural equation modeling analysis.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 12, Iss 2, p e0172779 (2017)
Abstract: OBJECTIVE:To identify coping strategies and socio-demographics impacting satisfaction with life and quality of life in Crohn's disease (CD). METHODS:402 patients completed the Patient Harvey-Bradshaw Index, Brief COPE Inventory, Satisfaction with Life ...