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Proteomic Mapping of the Interactome of KRAS Mutants Identifies New Features of RAS Signalling Networks and the Mechanism of Action of Sotorasib
Publication Type: Academic Journal
Source(s): Cancers, Vol 15, Iss 4141, p 4141 (2023)
Abstract: RAS proteins are key regulators of cell signalling and control different cell functions including cell proliferation, differentiation, and cell death. Point mutations in the genes of this family are common, particularly in KRAS. These mutations were th...
Postnatal corticosteroid use for prevention or treatment of bronchopulmonary dysplasia in England and Wales 2012–2019: a retrospective population cohort study
Publication Type: Academic Journal
Source(s): BMJ Open, Vol 12, Iss 11 (2022)
Abstract: Objective Describe the population of babies who do and do not receive postnatal corticosteroids for prevention or treatment of bronchopulmonary dysplasia (BPD).Design Retrospective cohort study using data held in the National Neonatal Research Database...
Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response
Publication Type: Academic Journal
Source(s): Cell Reports: Methods, Vol 2, Iss 9, Pp 100279- (2022)
Abstract: Summary: Determining the protection an individual has to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VoCs) is crucial for future immune surveillance, vaccine development, and understanding of the changing immune re...
Neuropsychiatric manifestations and sleep disturbances with dolutegravir-based antiretroviral therapy versus standard of care in children and adolescents: a secondary analysis of the ODYSSEY trial
Publication Type: Periodical
Source(s): The Lancet Child & Adolescent Health; October 2023, Vol. 7 Issue: 10 p718-727, 10p
Abstract: Cohort studies in adults with HIV showed that dolutegravir was associated with neuropsychiatric adverse events and sleep problems, yet data are scarce in children and adolescents. We aimed to evaluate neuropsychiatric manifestations in children and ado...
Increase in the use of inhaled nitric oxide in neonatal intensive care units in England: a retrospective population study
Publication Type: Academic Journal
Source(s): BMJ Paediatrics Open, Vol 5, Iss 1 (2021)
Abstract: Objective To describe temporal changes in inhaled nitric oxide (iNO) use in English neonatal units between 2010 and 2015.Design Retrospective analysis using data extracted from the National Neonatal Research Database.Setting All National Health Service...
Healthcare Workers Bioresource: Study outline and baseline characteristics of a prospective healthcare worker cohort to study immune protection and pathogenesis in COVID-19 [version 2; peer review: 1 approved, 2 approved with reservations]
Publication Type: Academic Journal
Source(s): Wellcome Open Research, Vol 5 (2020)
Abstract: Background: Most biomedical research has focused on sampling COVID-19 patients presenting to hospital with advanced disease, with less focus on the asymptomatic or paucisymptomatic. We established a bioresource with serial sampling of health care worke...
Association of SARS-CoV-2 Spike Protein Antibody Vaccine Response With Infection Severity in Patients With Cancer: A National COVID Cancer Cross-sectional Evaluation
Publication Type: Periodical
Source(s): JAMA Oncology; February 2023, Vol. 9 Issue: 2 p188-196, 9p
Abstract: IMPORTANCE: Accurate identification of patient groups with the lowest level of protection following COVID-19 vaccination is important to better target resources and interventions for the most vulnerable populations. It is not known whether SARS-CoV-2 a...
Maternal and neonatal outcomes after caesarean delivery in the African Surgical Outcomes Study: a 7-day prospective observational cohort study
Publication Type: Academic Journal
Source(s): The Lancet Global Health, Vol 7, Iss 4, Pp e513-e522 (2019)
Abstract: Summary: Background: Maternal and neonatal mortality is high in Africa, but few large, prospective studies have been done to investigate the risk factors associated with these poor maternal and neonatal outcomes. Methods: A 7-day, international, prospe...
Once-daily dolutegravir-based antiretroviral therapy in infants and children living with HIV from age 4 weeks: results from the below 14 kg cohort in the randomised ODYSSEY trial
Publication Type: Periodical
Source(s): The Lancet HIV; September 2022, Vol. 9 Issue: 9 pe638-e648, 11p
Abstract: Young children living with HIV have few treatment options. We aimed to assess the efficacy and safety of dolutegravir-based antiretroviral therapy (ART) in children weighing between 3 kg and less than 14 kg.
Dolutegravir twice-daily dosing in children with HIV-associated tuberculosis: a pharmacokinetic and safety study within the open-label, multicentre, randomised, non-inferiority ODYSSEY trial
Publication Type: Periodical
Source(s): The Lancet HIV; September 2022, Vol. 9 Issue: 9 pe627-e637, 11p
Abstract: Children with HIV-associated tuberculosis (TB) have few antiretroviral therapy (ART) options. We aimed to evaluate the safety and pharmacokinetics of dolutegravir twice-daily dosing in children receiving rifampicin for HIV-associated TB.