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Advanced Search Results For "Wang, Zhi���Qiang"

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 "Wang, Zhi���Qiang"
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First-in-human phase Ia study of the PI3Kα inhibitor CYH33 in patients with solid tumors

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)

Abstract: PIK3CA is a commonly mutated cancer-associated gene, making it an attractive therapeutic target. Here, the authors report the results of a first-in-human phase Ia trial to assess the safety and recommended phase II dose of CYH33, a PI3Kα inhibitor, in ...

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The design and application of an individualized 3D printing assisted guide plates in assisting sacroiliac screws insertion

Publication Type: Academic Journal

Source(s): Computer Assisted Surgery, Vol 27, Iss 1, Pp 113-119 (2022)

Abstract: Objective Currently, the sacroiliac screws insertion still faces several challenges in the fixation of pelvic and acetabular injuries. This study was aimed to design a personalized three-dimensional (3D) printing assisted guide plates to assist sacroil...

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A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy

Publication Type: Academic Journal

Source(s): Drug Delivery, Vol 29, Iss 1, Pp 128-137 (2022)

Abstract: Chemotherapy is one of the main ways to treat breast cancer clinically. However, the multidrug resistance to anti-tumor drugs limits their clinical use. To overcome these drawbacks, development of drug delivery systems (DDSs) has attracted more and mor...

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The semi-extended infrapatellar intramedullary nailing of distal tibia fractures: a randomized clinical trial

Publication Type: Academic Journal

Source(s): Journal of Orthopaedics and Traumatology, Vol 23, Iss 1, Pp 1-13 (2022)

Abstract: Abstract Background Malalignment is a common event during the intramedullary nailing (IMN) of distal tibia fractures (DTFs). Although it is reported that the semi-extended IMN techniques such as suprapatellar (SP) and parapatellar (PP) approaches may b...

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The long-term survival of the doublet regimen of concurrent chemoradiation therapy for locoregionally advanced nasopharyngeal carcinoma: a retrospective study

Publication Type: Academic Journal

Source(s): Radiation Oncology, Vol 17, Iss 1, Pp 1-9 (2022)

Abstract: Abstract Objective This study introduces innovative strategies, the doublet regimen of concurrent chemoradiotherapy, to ensure longer survival for locoregionally advanced nasopharyngeal carcinoma. Methods We retrospectively reviewed 104 locoregionally ...

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Photoredox-catalyzed C–C bond cleavage of cyclopropanes for the formation of C(sp 3)–heteroatom bonds

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Abstract: The development of new methodologies for the construction of C(sp 3)–heteroatom bonds under mild conditions is desirable. Here the authors report the formation of C(sp 3)–heteroatom bonds via ring opening of arylcyclopropanes enabled by photoredox cata...

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Proximal fibular osteotomy versus high tibial osteotomy for treating knee osteoarthritis: a systematic review and meta-analysis

Publication Type: Academic Journal

Source(s): Journal of Orthopaedic Surgery and Research, Vol 17, Iss 1, Pp 1-17 (2022)

Abstract: Abstract Background Knee osteoarthritis (KOA) with varus alignment and medial space stenosis is a common degenerative disorder in the elderly. To reallocate the force bearing from the medial to the lateral compartment, the anti-varus osteotomy, includi...

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Causal associations between blood pressure and the risk of myocardial infarction: A bidirectional Mendelian randomization study

Publication Type: Academic Journal

Source(s): Frontiers in Cardiovascular Medicine, Vol 9 (2022)

Abstract: IntroductionMany observational studies imply elevated blood pressure (BP) as a leading risk factor for incident myocardial infarction (MI), but whether this relationship is causal remains unknown. In this study, we used bidirectional Mendelian randomiz...

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Oncological outcomes of anatomic versus non-anatomic resections for small hepatocellular carcinoma: systematic review and meta-analysis of propensity-score matched studies

Publication Type: Academic Journal

Source(s): World Journal of Surgical Oncology, Vol 20, Iss 1, Pp 1-12 (2022)

Abstract: Abstract Background Primary liver cancer is the second-most commonly occurring cancer and has resulted in numerous deaths worldwide. Hepatic resection is of two main types, i.e., anatomic resection (AR) and non-anatomic resection (NAR). The oncological...

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Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability

Publication Type: Academic Journal

Source(s): Military Medical Research, Vol 9, Iss 1, Pp 1-19 (2022)

Abstract: Abstract Background Melatonin, a natural hormone secreted by the pineal gland, has been reported to exhibit antitumor properties through diverse mechanisms of action. However, the oncostatic function of melatonin on esophageal squamous cell carcinoma (...

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