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Efficacy of neoadjuvant treatment with or without pertuzumab in patients with stage II and III HER2-positive breast cancer: a nationwide cohort analysis of pathologic response and 5-year survival
Publication Type: Academic Journal
Source(s): Breast, Vol 65, Iss , Pp 110-115 (2022)
Abstract: Background: Pathologic complete response (pCR) rates in early stage HER2-positive breast cancer improved after pertuzumab was added to neoadjuvant treatment. However, survival benefit is less-well established and seems mostly limited to node-positive p...
Healthcare and treatment experiences among people diagnosed with HIV before and after a province-wide treatment as prevention initiative in British Columbia, Canada
Publication Type: Academic Journal
Source(s): BMC Public Health, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract: Abstract Introduction In 2010, the Canadian province of British Columbia (BC) initiated the Seek and Treat for Optimal Prevention of HIV/AIDS (STOP HIV/AIDS) program to improve HIV testing, linkage to care, and treatment uptake, thereby operationalizin...
Comprehensive characterization of pre- and post-treatment samples of breast cancer reveal potential mechanisms of chemotherapy resistance
Publication Type: Academic Journal
Source(s): npj Breast Cancer, Vol 8, Iss 1, Pp 1-12 (2022)
Abstract: Abstract When locally advanced breast cancer is treated with neoadjuvant chemotherapy, the recurrence risk is significantly higher if no complete pathologic response is achieved. Identification of the underlying resistance mechanisms is essential to se...
Common variants in breast cancer risk loci predispose to distinct tumor subtypes
Publication Type: Academic Journal
Source(s): Breast Cancer Research, Vol 24, Iss 1, Pp 1-13 (2022)
Abstract: Abstract Background Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with...
Non-invasively measured brain activity and radiological progression in diffuse glioma
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract: Abstract Non-invasively measured brain activity is related to progression-free survival in glioma patients, suggesting its potential as a marker of glioma progression. We therefore assessed the relationship between brain activity and increasing tumor v...
Prediction Models and Decision Aids for Women with Ductal Carcinoma In Situ: A Systematic Literature Review
Publication Type: Academic Journal
Source(s): Cancers, Vol 14, Iss 3259, p 3259 (2022)
Abstract: Even though Ductal Carcinoma in Situ (DCIS) can potentially be an invasive breast cancer (IBC) precursor, most DCIS lesions never will progress to IBC if left untreated. Because we cannot predict yet which DCIS lesions will and which will not progress,...
Neurooncology: 2022 update
Publication Type: Academic Journal
Source(s): Free Neuropathology, Vol 3 (2022)
Abstract: Abstract This ‘Neurooncology: 2022 update’ presents topics that were selected by the authors as top ten discoveries published in 2021 in the broader field of neurooncological pathology. This time, the spectrum of topics includes: papers with a direct...
Epithelial-to-Mesenchymal Transition Drives Invasiveness of Breast Cancer Brain Metastases
Publication Type: Academic Journal
Source(s): Cancers, Vol 14, Iss 3115, p 3115 (2022)
Abstract: (1) Background: an increasing number of breast cancer patients develop lethal brain metastases (BM). The complete removal of these tumors by surgery becomes complicated when cells infiltrate into the brain parenchyma. However, little is known about the...
Association between Clinical Frailty Scale score and hospital mortality in adult patients with COVID-19 (COMET): an international, multicentre, retrospective, observational cohort study
Publication Type: Academic Journal
Source(s): The Lancet. Healthy Longevity, Vol 2, Iss 3, Pp e163-e170 (2021)
Abstract: Summary: Background: During the COVID-19 pandemic, the scarcity of resources has necessitated triage of critical care for patients with the disease. In patients aged 65 years and older, triage decisions are regularly based on degree of frailty measured...
Efficacy of neoadjuvant treatment with or without pertuzumab in patients with stage II and III HER2-positive breast cancer: a nationwide cohort analysis of pathologic response and 5-year survival.
Publication Type: Academic Journal
Source(s): Breast; Oct2022, Vol. 65, p110-115, 6p
Abstract: Copyright of Breast is the property of Churchill Livingstone, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or ...