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Advanced Search Results For "Wilkerson, Michael G."

1 - 10 of 164 results for
 "Wilkerson, Michael G."
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Peptide ancestry informative markers in uterine neoplasms from women of European, African, and Asian ancestry

Publication Type: Academic Journal

Source(s): iScience, Vol 25, Iss 1, Pp 103665- (2022)

Abstract: Summary: Characterization of ancestry-linked peptide variants in disease-relevant patient tissues represents a foundational step to connect patient ancestry with disease pathogenesis. Nonsynonymous single-nucleotide polymorphisms encoding missense subs...

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First operation of the KATRIN experiment with tritium

Publication Type: Academic Journal

Source(s): European Physical Journal C: Particles and Fields, Vol 80, Iss 3, Pp 1-18 (2020)

Abstract: Abstract The determination of the neutrino mass is one of the major challenges in astroparticle physics today. Direct neutrino mass experiments, based solely on the kinematics of $$\upbeta $$ β -decay, provide a largely model-independent probe to the n...

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Distribution of lymph node metastases in esophageal carcinoma [TIGER study]: study protocol of a multinational observational study

Publication Type: Academic Journal

Source(s): BMC Cancer, Vol 19, Iss 1, Pp 1-8 (2019)

Abstract: Abstract Background An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, invasion depth, and on neo...

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Integrated Molecular Characterization of Testicular Germ Cell Tumors

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 11, Pp 3392-3406 (2018)

Abstract: Summary: We studied 137 primary testicular germ cell tumors (TGCTs) using high-dimensional assays of genomic, epigenomic, transcriptomic, and proteomic features. These tumors exhibited high aneuploidy and a paucity of somatic mutations. Somatic mutatio...

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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 313-326.e5 (2018)

Abstract: Summary: Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic sub...

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Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 227-238.e3 (2018)

Abstract: Summary: Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% ...

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Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 181-193.e7 (2018)

Abstract: Summary: Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images f...

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Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 255-269.e4 (2018)

Abstract: Summary: Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven...

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Systematic Analysis of Splice-Site-Creating Mutations in Cancer

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 270-281.e3 (2018)

Abstract: Summary: For the past decade, cancer genomic studies have focused on mutations leading to splice-site disruption, overlooking those having splice-creating potential. Here, we applied a bioinformatic tool, MiSplice, for the large-scale discovery of spli...

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Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 239-254.e6 (2018)

Abstract: Summary: DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying ...

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