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Disease evolution in systemic juvenile idiopathic arthritis: an international, observational cohort study through JIRcohort
Publication Type: Academic Journal
Source(s): Pediatric Rheumatology Online Journal, Vol 21, Iss 1, Pp 1-9 (2023)
Abstract: Abstract Background Systemic juvenile idiopathic arthritis (systemic JIA) is a severe disease with both systemic and joint inflammation. This study aims to identify predictors of disease evolution within the systemic JIA population enrolled in the Juve...
Genetic insights into resting heart rate and its role in cardiovascular disease
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract: Abstract Resting heart rate is associated with cardiovascular diseases and mortality in observational and Mendelian randomization studies. The aims of this study are to extend the number of resting heart rate associated genetic variants and to obtain f...
Limited wedge resection for T1 colon cancer (LIMERIC-II trial) – rationale and study protocol of a prospective multicenter clinical trial
Publication Type: Academic Journal
Source(s): BMC Gastroenterology, Vol 23, Iss 1, Pp 1-9 (2023)
Abstract: Abstract Background The sole presence of deep submucosal invasion is shown to be associated with a limited risk of lymph node metastasis. This justifies a local excision of suspected deep submucosal invasive colon carcinomas (T1 CCs) as a first step tr...
Mass balance of the Greenland and Antarctic ice sheets from 1992 to 2020
Publication Type: Academic Journal
Source(s): Earth System Science Data, Vol 15, Pp 1597-1616 (2023)
Abstract: Ice losses from the Greenland and Antarctic ice sheets have accelerated since the 1990s, accounting for a significant increase in the global mean sea level. Here, we present a new 29-year record of ice sheet mass balance from 1992 to 2020 from the Ice ...
SARS-CoV-2 incidence in secondary schools; the role of national and school-initiated COVID-19 measures
Publication Type: Academic Journal
Source(s): BMC Public Health, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract: Abstract Introduction Our aim was to gain insight into the effect of COVID-19 measures on SARS-CoV-2 incidence in secondary schools and the association with classroom CO2 concentration and airborne contamination. Methods Between October 2020—June 2021,...
The Epigenetic Reader Protein SP140 Regulates Dendritic Cell Activation, Maturation and Tolerogenic Potential
Publication Type: Academic Journal
Source(s): Current Issues in Molecular Biology, Vol 45, Iss 269, Pp 4228-4245 (2023)
Abstract: SP140 is an epigenetic reader protein expressed predominantly in immune cells. GWAS studies have shown an association between SP140 single nucleotide polymorphisms (SNPs) and diverse autoimmune and inflammatory diseases, suggesting a possible pathogeni...
Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infectionResearch in context
Publication Type: Academic Journal
Source(s): EBioMedicine, Vol 94, Iss , Pp 104729- (2023)
Abstract: Summary: Background: Post-acute sequela of SARS-CoV-2 infection (PASC) encompass fatigue, post-exertional malaise and cognitive problems. The abundant expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase-2 (IDO2) in fatal/severe...
Gut dysbiosis associates with cytokine production capacity in viral-suppressed people living with HIV
Publication Type: Academic Journal
Source(s): Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Abstract: BackgroundPeople living with human immunodeficiency virus (PLHIV) are exposed to chronic immune dysregulation, even when virus replication is suppressed by antiretroviral therapy (ART). Given the emerging role of the gut microbiome in immunity, we hypo...
Effectiveness of laparoscopic niche resection versus expectant management in patients with unexplained infertility and a large uterine caesarean scar defect (uterine niche): protocol for a randomised controlled trial (the LAPRES study)
Publication Type: Academic Journal
Source(s): BMJ Open, Vol 13, Iss 7 (2023)
Abstract: Introduction A uterine niche is a defect at the site of the uterine caesarean scar that is associated with gynaecological symptoms and infertility. Promising results are reported in cohort studies after a laparoscopic niche resection concerning reducti...
Myokines as mediators of exercise-induced cognitive changes in older adults: protocol for a comprehensive living systematic review and meta-analysis
Publication Type: Academic Journal
Source(s): Frontiers in Aging Neuroscience, Vol 15 (2023)
Abstract: BackgroundThe world’s population is aging, but life expectancy has risen more than healthy life expectancy (HALE). With respect to brain and cognition, the prevalence of neurodegenerative disorders increases with age, affecting health and quality of li...