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Anti-NET antibodies in antiphospholipid antibody-positive patients: Results from the Antiphospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS ACTION) Clinical Database and Repository.
Publication Type: Academic Journal
Source(s): Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2023 Mar 02. Date of Electronic Publication: 2023 Mar 02.
Abstract: Objective: Our study aimed to elucidate the presence, antigen specificities, and potential clinical association of anti-neutrophil extracellular trap (anti-NET) antibodies in a multinational cohort of antiphospholipid antibody (aPL)-positive patients w...
Formulation and biopharmaceutical evaluation of risperidone-loaded chitosan nanoparticles for intranasal delivery.
Publication Type: Academic Journal
Source(s): Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2019 Aug; Vol. 45 (8), pp. 1342-1350. Date of Electronic Publication: 2019 Jun 03.
Abstract: Objective: High lipophilicity and extensive hepatic metabolism limits the oral application of risperidone in the treatment of CNS disorders. In order address this limitation, risperidone (RS) loaded chitosan nanoparticles (CS-NPs) were processed for in...
Biopharmaceutical Potential of Selegiline Loaded Chitosan Nanoparticles in the Management of Parkinson's Disease.
Publication Type: Academic Journal
Source(s): Current drug discovery technologies [Curr Drug Discov Technol] 2019; Vol. 16 (4), pp. 417-425.
Abstract: Background: Selegiline hydrochloride, a hydrophilic anti-Parkinson' moiety, undergoes extensive first-pass metabolism and has low bioavailability. A process to obtain of selegiline (SH) loaded chitosan nanoparticles was attempted to circumvent the abov...
Biopharmaceutical Process of Diclofenac Multi-particulate Systems for Chronotherapy of Rheumatoid Arthritis.
Publication Type: Academic Journal
Source(s): Turkish journal of pharmaceutical sciences [Turk J Pharm Sci] 2018 Dec; Vol. 15 (3), pp. 256-262. Date of Electronic Publication: 2018 Nov 20.
Abstract: Objectives: Diclofenac exhibits limited solubility, low bioabsorption and gastric toxicity. The objective of the study was to address the above limitations and to design a multi-particulate formulation for the chronotherapy of RA.Materials and Methods:...
Biopharmaceutical insights of particulate emulsified systems - a prospective overview.
Publication Type: Academic Journal
Source(s): Lipids in health and disease [Lipids Health Dis] 2018 May 10; Vol. 17 (1), pp. 112. Date of Electronic Publication: 2018 May 10.
Abstract: During the twenty-first century, drug discovery is expanding rapidly and a large number of chemical moieties are recognized. Many of them are poorly soluble and hence related biopharmaceutical constraints are to be addressed systematically. Among novel...
Oxaprozin prodrug as safer nonsteroidal anti-inflammatory drug: Synthesis and pharmacological evaluation.
Publication Type: Academic Journal
Source(s): Archiv der Pharmazie [Arch Pharm (Weinheim)] 2018 Feb; Vol. 351 (2). Date of Electronic Publication: 2017 Dec 28.
Abstract: Oxaprozin is a popular non-steroidal anti-inflammatory drug (NSAID) and its chronic oral use is clinically restricted due to its gastrointestinal (GI) complications. In order to circumvent the GI complications, oxaprozin was amended as a prodrug in a o...
Process, Physicochemical Characterization and In-Vitro Assessment of Albendazole Microcrystals.
Publication Type: Academic Journal
Source(s): Advanced pharmaceutical bulletin [Adv Pharm Bull] 2017 Sep; Vol. 7 (3), pp. 419-425. Date of Electronic Publication: 2017 Sep 25.
Abstract: Purpose: Albendazole is a poorly soluble drug which limits its oral bioavailability. The study was focussed to enhance the solubility by in-situ micronization. Methods: Albendazole microcrystals were prepared by solvent ch...
In vitro characterization studies of self-microemulsified bosentan systems.
Publication Type: Academic Journal
Source(s): Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2017 Jun; Vol. 43 (6), pp. 989-995. Date of Electronic Publication: 2017 Feb 16.
Abstract: Context: Bosentan is a poorly soluble drug and pose challenges in designing of drug delivery systems.Objective: The objective of this study is to enhance the solubility, dissolution and shelf-life of bosentan by formulating it as S-SMEDDS capsules.Mate...
Synthesis and Pharmacological Evaluation of Acrylate-Based Gastrosparing NSAID Prodrugs.
Publication Type: Academic Journal
Source(s): Archiv der Pharmazie [Arch Pharm (Weinheim)] 2017 Apr; Vol. 350 (3-4). Date of Electronic Publication: 2017 Feb 28.
Abstract: Dexibuprofen and aceclofenac are well-known NSAID molecules, their oral use leads to gastrointestinal (GI) toxicity. To circumvent that GI toxicity, the prodrug approach is a better alternative. Hence, this research was undertaken to synthesize prodrug...
Chronopharmacokinetic Evaluation of Budesonide Multiparticulate Systems.
Publication Type: Academic Journal
Source(s): Recent patents on drug delivery & formulation [Recent Pat Drug Deliv Formul] 2017; Vol. 11 (3), pp. 221-229.
Abstract: Background: Poor oral absorption of budesonide limits the design of its solid oral dosage form. With this context, multiparticulate pulsatile system of budesonide for chronotherapy of nocturnal asthma was aimed in this study.Methods: Initially, solid d...