Advanced Search Results For "Yoshida, Kazuto"
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The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Abstract: Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splic...
Canine induced pluripotent stem cells efficiently differentiate into definitive endoderm in 3D cell culture conditions using high-dose activin A
Publication Type: Academic Journal
Source(s): Regenerative Therapy, Vol 21, Iss , Pp 502-510 (2022)
Abstract: Introduction: Endoderm-derived organs support indispensable functions in the body. Pluripotent stem cells can generate endoderm-derived cells or tissues and have excellent therapeutic potential to replace the functions of endodermal tissues. However, t...
Evaluation of clinical outcomes with propensity‐score matching for colorectal cancer presenting as an oncologic emergency
Publication Type: Academic Journal
Source(s): Annals of Gastroenterological Surgery, Vol 6, Iss 4, Pp 523-530 (2022)
Abstract: Abstract Aim Oncologic emergencies such as perforation and obstruction associated with colorectal cancer are serious diseases that can lead to sepsis. Peritoneal dissemination and other factors may cause cancer progression and worsen the patients’ long...
Safety and tolerability of aripiprazole in patients with psychosis associated with Parkinson's disease—Results of a multicenter open trial
Publication Type: Academic Journal
Source(s): Neuropsychopharmacology Reports, Vol 42, Iss 2, Pp 135-141 (2022)
Abstract: Abstract Aim To evaluate the effect of aripiprazole on psychosis and motor function in Japanese Parkinson's disease patients. Methods Patients with Parkinson's disease and hallucinations and/or delusions were enrolled. They were administered aripiprazo...
Fully automated and highly specific plasma β-amyloid immunoassays predict β-amyloid status defined by amyloid positron emission tomography with high accuracy
Publication Type: Academic Journal
Source(s): Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-10 (2022)
Abstract: Abstract Background Clinicians, researchers, and patients alike would greatly benefit from more accessible and inexpensive biomarkers for neural β-amyloid (Aβ). We aimed to assess the performance of fully automated plasma Aβ immunoassays, which correla...
Possible role of insulin resistance in activation of plasma xanthine oxidoreductase in health check-up examinees
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract: Abstract We previously found an association of insulin resistance (IR) with plasma xanthine oxidoreductase (XOR) activity in a cross-sectional study. However, whether IR induces increased XOR activity has not been elucidated. This retrospective longitu...
A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the StomachSummary
Publication Type: Academic Journal
Source(s): Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 5, Pp 1317-1345 (2022)
Abstract: Background & Aims: RUNX transcription factors play pivotal roles in embryonic development and neoplasia. We previously identified the single missense mutation R122C in RUNX3 from human gastric cancer. However, how RUNX3R122C mutation disrupts stem cell...
Prognostic Value of Pretreatment Red Blood Cell Distribution Width in Patients With Esophageal Cancer Who Underwent Esophagectomy
Publication Type: Academic Journal
Source(s): Annals of Surgery Open, Vol 3, Iss 2, p e153 (2022)
Abstract: Objective:. This comprehensive analysis aimed to elucidate the mechanism underlying how high pretreatment red blood cell distribution width (RDW) reflects poor prognosis after esophagectomy for esophageal cancer. Background:. Several cohort studies hav...
Uric acid shown to contribute to increased oxidative stress level independent of xanthine oxidoreductase activity in MedCity21 health examination registry
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract: Abstract Uric acid has both antioxidant and pro-oxidant properties in vitro by scavenging and production of reactive oxygen species (ROS). This cross-sectional study examined whether uric acid possesses effects on oxidative stress under physiological c...
Pan-immune-inflammation Value and Prognosis in Patients With Esophageal Cancer
Publication Type: Academic Journal
Source(s): Annals of Surgery Open, Vol 3, Iss 1, p e113 (2022)
Abstract: Mini-abstract:. The pan-immune-inflammation value was associated with clinical outcomes and tumor-infiltrating lymphocytes in 866 esophageal cancers. Systemic immune competence may influence patient prognosis through local immune response. Objective:. ...