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Advanced Search Results For "Yun-Ching Chen"

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 "Yun-Ching Chen"
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Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer

Publication Type: Academic Journal

Source(s): Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-13 (2022)

Abstract: Abstract Background Castration-resistant prostate cancer (CRPC) with sustained androgen receptor (AR) signaling remains a critical clinical challenge, despite androgen depletion therapy. The Jumonji C-containing histone lysine demethylase family 4 (KDM...

A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency

Publication Type: Academic Journal

Source(s): Genome Biology, Vol 22, Iss 1, Pp 1-38 (2021)

Abstract: Abstract Background Oncopanel genomic testing, which identifies important somatic variants, is increasingly common in medical practice and especially in clinical trials. Currently, there is a paucity of reliable genomic reference samples having a suita...

Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection

Publication Type: Academic Journal

Source(s): Frontiers in Genetics, Vol 12 (2021)

Abstract: Analyzing host cells' transcriptional response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection will help delineate biological processes underlying viral pathogenesis. First, analysis of expression profiles of lung cell lines A...

Genome-Wide Analysis of Off-Target CRISPR/Cas9 Activity in Single-Cell-Derived Human Hematopoietic Stem and Progenitor Cell Clones

Publication Type: Academic Journal

Source(s): Genes, Vol 11, Iss 1501, p 1501 (2020)

Abstract: CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9)-mediated genome editing holds remarkable promise for the treatment of human genetic diseases. However, the possibility of off-target Cas9 activity remai...

Affected Sib-Pair Analyses Identify Signaling Networks Associated With Social Behavioral Deficits in Autism

Publication Type: Academic Journal

Source(s): Frontiers in Genetics, Vol 10 (2019)

Abstract: Autism spectrum disorders (ASDs) are characterized by deficits in three core behavioral domains: reciprocal social interactions, communication, and restricted interests and/or repetitive behaviors. Several hundreds of risk genes for autism have been id...

Aberrant DNA methylation defines isoform usage in cancer, with functional implications.

Publication Type: Academic Journal

Source(s): PLoS Computational Biology, Vol 15, Iss 7, p e1007095 (2019)

Abstract: Alternative transcript isoforms are common in tumors and act as potential drivers of cancer. Mechanisms determining altered isoform expression include somatic mutations in splice regulatory sites or altered splicing factors. However, since DNA methylat...

Misregulation of ELK1, AP1, and E12 Transcription Factor Networks Is Associated with Melanoma Progression

Publication Type: Academic Journal

Source(s): Cancers, Vol 12, Iss 2, p 458 (2020)

Abstract: Melanoma is among the most malignant cutaneous cancers and when metastasized results in dramatically high mortality. Despite advances in high-throughput gene expression profiling in cancer transcriptomic studies, our understanding of mechanisms driving...

Significant associations between driver gene mutations and DNA methylation alterations across many cancer types.

Publication Type: Academic Journal

Source(s): PLoS Computational Biology, Vol 13, Iss 11, p e1005840 (2017)

Abstract: Recent evidence shows that mutations in several driver genes can cause aberrant methylation patterns, a hallmark of cancer. In light of these findings, we hypothesized that the landscapes of tumor genomes and epigenomes are tightly interconnected. We m...

A probabilistic model to predict clinical phenotypic traits from genome sequencing.

Publication Type: Academic Journal

Source(s): PLoS Computational Biology, Vol 10, Iss 9, p e1003825 (2014)

Abstract: Genetic screening is becoming possible on an unprecedented scale. However, its utility remains controversial. Although most variant genotypes cannot be easily interpreted, many individuals nevertheless attempt to interpret their genetic information. In...

A hybrid likelihood model for sequence-based disease association studies.

Publication Type: Academic Journal

Source(s): PLoS Genetics, Vol 9, Iss 1, p e1003224 (2013)

Abstract: In the past few years, case-control studies of common diseases have shifted their focus from single genes to whole exomes. New sequencing technologies now routinely detect hundreds of thousands of sequence variants in a single study, many of which are ...