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Advanced Search Results For "Zandi, Peter P."

1 - 10 of 573 results for
 "Zandi, Peter P."
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Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population

Publication Type: Periodical

Source(s): Molecular Psychiatry; 20230101, Issue: Preprints p1-10, 10p

Abstract: Genome-wide association studies (GWAS) of mood disorders in large case-control cohorts have identified numerous risk loci, yet pathophysiological mechanisms remain elusive, primarily due to the very small effects of common variants. We sought to discov...

Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder

Publication Type: Periodical

Source(s): Molecular Psychiatry; September 2022, Vol. 27 Issue: 9 p3842-3856, 15p

Abstract: Bipolar disorder is an often-severe mental health condition characterized by alternation between extreme mood states of mania and depression. Despite strong heritability and the recent identification of 64 common variant risk loci of small effect, path...

Exome sequencing in bipolar disorder identifies AKAP11as a risk gene shared with schizophrenia

Publication Type: Periodical

Source(s): Nature Genetics; May 2022, Vol. 54 Issue: 5 p541-547, 7p

Abstract: We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We find an excess of ultra-rare protein-truncating variants (PTVs) in patients...

Association of Attention-Deficit/Hyperactivity Disorder and Depression Polygenic Scores with Lithium Response: A Consortium for Lithium Genetics Study

Publication Type: Periodical

Source(s): Complex Psychiatry; December 2021, Vol. 7 Issue: 3-4 p80-89, 10p

Abstract: Response to lithium varies widely between individuals with bipolar disorder (BD). Polygenic risk scores (PRSs) can uncover pharmacogenomics effects and may help predict drug response. Patients (N= 2,510) with BD were assessed for long-term lithium resp...

Cross-species Association Between Telomere Length and Glucocorticoid Exposure.

Publication Type: Academic Journal

Source(s): Journal of Clinical Endocrinology & Metabolism; Dec2021, Vol. 106 Issue 12, pe5124-e5135, 12p

Abstract: Copyright of Journal of Clinical Endocrinology & Metabolism is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permissio...

Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways

Publication Type: Periodical

Source(s): Nature Neuroscience; March 2022, Vol. 25 Issue: 3 p381-389, 9p

Abstract: Recent genetic studies have identified variants associated with bipolar disorder (BD), but it remains unclear how brain gene expression is altered in BD and how genetic risk for BD may contribute to these alterations. Here, we obtained transcriptomes f...

Methylomic and transcriptomic predictors of one-month exposure to cortisol in healthy individuals.

Publication Type: Academic Journal

Source(s): Stress: The International Journal on the Biology of Stress; Nov 2021, Vol. 24 Issue 6, p840-848, 9p

Abstract: Copyright of Stress: The International Journal on the Biology of Stress is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permis...

Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder

Publication Type: Periodical

Source(s): Molecular Psychiatry; September 2021, Vol. 26 Issue: 9 p5239-5250, 12p

Abstract: Bipolar disorder (BD) is a serious mental illness with substantial common variant heritability. However, the role of rare coding variation in BD is not well established. We examined the protein-coding (exonic) sequences of 3,987 unrelated individuals w...

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