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Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2).
Publication Type: Academic Journal
Source(s): Journal of medicinal chemistry [J Med Chem] 2017 May 25; Vol. 60 (10), pp. 4403-4423. Date of Electronic Publication: 2017 May 15.
Abstract: LOXL2 catalyzes the oxidative deamination of ε-amines of lysine and hydroxylysine residues within collagen and elastin, generating reactive aldehydes (allysine). Condensation with other allysines or lysines drives the formation of inter- and intramolec...
Therapeutic drug monitoring for invasive mould infections and disease: pharmacokinetic and pharmacodynamic considerations.
Publication Type: Academic Journal
Source(s): The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2017 Mar 01; Vol. 72 (suppl_1), pp. i12-i18.
Abstract: Therapeutic drug monitoring (TDM) may be required to achieve optimal clinical outcomes in the setting of significant pharmacokinetic variability, a situation that applies to a number of anti-mould therapies. The majority of patients receiving itraconaz...
Population Pharmacokinetics of Edoxaban in Patients with Non-Valvular Atrial Fibrillation in the ENGAGE AF-TIMI 48 Study, a Phase III Clinical Trial.
Publication Type: Academic Journal
Source(s): Clinical pharmacokinetics [Clin Pharmacokinet] 2016 Sep; Vol. 55 (9), pp. 1079-90.
Abstract: Introduction: Edoxaban is a novel factor Xa inhibitor. This study characterizes the population pharmacokinetics of edoxaban in patients with non-valvular atrial fibrillation (NVAF) included in the phase III ENGAGE AF-TIMI 48 study, evaluates covariates...
Simultaneous Determination of Aesculin, Aesculetin, Fraxetin, Fraxin and Polydatin in Beagle Dog Plasma by UPLC-ESI-MS/MS and Its Application in a Pharmacokinetic Study after Oral Administration Extracts of Ledum palustre L.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2018 Sep 07; Vol. 23 (9). Date of Electronic Publication: 2018 Sep 07.
Abstract: A rapid, simple and sensitive ultra-performance liquid chromatography-electrospray-ionization-tandem mass spectrometry (UPLC-ESI-MS/MS) method was developed and validated for the simultaneous determination of aesculin, aesculetin, fraxetin, fraxin and ...
UHPLC-MS/MS Quantification Combined with Chemometrics for Comparative Analysis of Different Batches of Raw, Wine-Processed, and Salt-Processed Radix Achyranthis Bidentatae.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2018 Mar 26; Vol. 23 (4). Date of Electronic Publication: 2018 Mar 26.
Abstract: An accurate and reliable method using ultra-high performance liquid chromatography combined with triple quadrupole tandem mass spectrometry (UHPLC-MS/MS) was established for simultaneous quantification of five major bioactive analytes in raw, wine-proc...
A UPLC-MS Method for Simultaneous Determination of Geniposidic Acid, Two Lignans and Phenolics in Rat Plasma and its Application to Pharmacokinetic Studies of Eucommia ulmoides Extract in Rats.
Publication Type: Academic Journal
Source(s): European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2016 Oct; Vol. 41 (5), pp. 595-603.
Abstract: The bark of Eucommia ulmoides is a well-known Chinese herbal medicine that is used to regulate blood pressure and reduce blood sugar and fats, as well as an antioxidant and antimicrobial agent. Here we describe the development of a sensitive ultrahigh ...
An LC-MS/MS method for the simultaneous determination of lycorine and galanthamine in rat plasma and its application to pharmacokinetic study of Lycoris radiata extract in rats.
Publication Type: Academic Journal
Source(s): Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban [J Huazhong Univ Sci Technolog Med Sci] 2014 Dec; Vol. 34 (6), pp. 861-868. Date of Electronic Publication: 2014 Dec 06.
Abstract: A rapid, sensitive, and selective liquid chromatography-tandem mass spectrometry was developed for the simultaneous determination of lycorine and galanthamine, two major constituents in Lycoris radiata extract, in rat plasma. Liquid-liquid extraction w...
A LC-ESI-MS method for the simultaneous determination of madecassoside and its metabolite madecassic acid in rat plasma: comparison pharmacokinetics in normal and collagen-induced arthritic rats.
Publication Type: Academic Journal
Source(s): Chinese journal of natural medicines [Chin J Nat Med] 2014 Dec; Vol. 12 (12), pp. 943-51.
Abstract: To develop a simple and highly sensitive high performance liquid chromatography with electrospray ionization mass spectrometric (LC-ESI-MS) method for the simultaneous determination of madecassoside and its major metabolite madecassic acid in rat plasm...
Analysis of hupehenine in the total alkaloids from Fritillaria hupehensis by HPLC-ELSD.
Publication Type: Academic Journal
Source(s): Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban [J Huazhong Univ Sci Technolog Med Sci] 2008 Feb; Vol. 28 (1), pp. 118-20.
Abstract: A reverse-phase high pressure liquid chromatography (HPLC) method with evaporative light scattering detection (ELSD) has been developed for the quantitative analysis of hupehenine in the total alkaloids from Fritillaria hupehensis. Samples were analyze...