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    • Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components.

    Publication Type: Academic Journal

    Source(s): Nature [Nature] 2017 Dec 06; Vol. 552 (7683), pp. 72-77.

    Abstract: Nucleic acids (DNA and RNA) are widely used to construct nanometre-scale structures with ever increasing complexity, with possible application in fields such as structural biology, biophysics, synthetic biology and photonics. The nanostructures are for...

    Therapeutic drug monitoring for invasive mould infections and disease: pharmacokinetic and pharmacodynamic considerations.

    Publication Type: Academic Journal

    Source(s): The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2017 Mar 01; Vol. 72 (suppl_1), pp. i12-i18.

    Authors:

    Abstract: Therapeutic drug monitoring (TDM) may be required to achieve optimal clinical outcomes in the setting of significant pharmacokinetic variability, a situation that applies to a number of anti-mould therapies. The majority of patients receiving itraconaz...

    How mouse RAG recombinase avoids DNA transposition.

    Publication Type: Academic Journal

    Source(s): Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Feb; Vol. 27 (2), pp. 127-133. Date of Electronic Publication: 2020 Feb 03.

    Authors:

    Abstract: The RAG1-RAG2 recombinase (RAG) cleaves DNA to initiate V(D)J recombination, but RAG also belongs to the RNH-type transposase family. To learn how RAG-catalyzed transposition is inhibited in developing lymphocytes, we determined the structure of a DNA-...

    Population Pharmacokinetics of Edoxaban in Patients with Non-Valvular Atrial Fibrillation in the ENGAGE AF-TIMI 48 Study, a Phase III Clinical Trial.

    Publication Type: Academic Journal

    Source(s): Clinical pharmacokinetics [Clin Pharmacokinet] 2016 Sep; Vol. 55 (9), pp. 1079-90.

    Abstract: Introduction: Edoxaban is a novel factor Xa inhibitor. This study characterizes the population pharmacokinetics of edoxaban in patients with non-valvular atrial fibrillation (NVAF) included in the phase III ENGAGE AF-TIMI 48 study, evaluates covariates...

    Assessing the potential of surface-immobilized molecular logic machines for integration with solid state technology.

    Publication Type: Academic Journal

    Source(s): Bio Systems [Biosystems] 2016 Aug; Vol. 146, pp. 3-9. Date of Electronic Publication: 2016 May 18.

    Abstract: Molecular computation with DNA has great potential for low power, highly parallel information processing in a biological or biochemical context. However, significant challenges remain for the field of DNA computation. New technology is needed to allow ...

    Au nanorod helical superstructures with designed chirality.

    Publication Type: Academic Journal

    Source(s): Journal of the American Chemical Society [J Am Chem Soc] 2015 Jan 14; Vol. 137 (1), pp. 457-62. Date of Electronic Publication: 2014 Dec 29.

    Authors:

    Abstract: A great challenge for nanotechnology is to controllably organize anisotropic nanomaterials into well-defined three-dimensional superstructures with customized properties. Here we successfully constructed anisotropic Au nanorod (AuNR) helical superstruc...

    Self-assembled DNA nanostructures for distance-dependent multivalent ligand-protein binding.

    Publication Type: Academic Journal

    Source(s): Nature nanotechnology [Nat Nanotechnol] 2008 Jul; Vol. 3 (7), pp. 418-22. Date of Electronic Publication: 2008 Jun 22.

    Authors:

    Abstract: An important goal of nanotechnology is to assemble multiple molecules while controlling the spacing between them. Of particular interest is the phenomenon of multivalency, which is characterized by simultaneous binding of multiple ligands on one biolog...

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