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Redox Biology in Adipose Tissue Physiology and Obesity.
Publication Type: Academic Journal
Source(s): Advanced biology [Adv Biol (Weinh)] 2023 Sep; Vol. 7 (9), pp. e2200234. Date of Electronic Publication: 2023 Jan 19.
Abstract: Reactive oxygen species (ROS), a by-product of mitochondrial oxidative phosphorylation and cellular metabolism, is vital for cellular survival, proliferation, damage, and senescence. In recent years, studies have shown that ROS levels and redox status ...
"Turning up the heat": role of neurotrophic batokines in the postnatal maturation and remodeling of brown adipose tissue in deer mice.
Publication Type: Academic Journal
Source(s): American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2023 Jul 01; Vol. 325 (1), pp. E32-E45. Date of Electronic Publication: 2023 May 24.
Abstract: Activation of brown adipose tissue (BAT) thermogenesis impacts energy balance and must be tightly regulated. Several neurotrophic factors, expressed in BAT of adult laboratory rodents, have been implicated in remodeling the sympathetic neural network t...
Brown Adipose Tissue-A Translational Perspective.
Publication Type: Academic Journal
Source(s): Endocrine reviews [Endocr Rev] 2023 Mar 04; Vol. 44 (2), pp. 143-192.
Abstract: Brown adipose tissue (BAT) displays the unique capacity to generate heat through uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for cardiometabolic diseases. Here, we review BAT cellular metabolism, its regulatio...
Development and validation of a nonenhanced CT based radiomics model to detect brown adipose tissue.
Publication Type: Academic Journal
Source(s): Theranostics [Theranostics] 2023 Mar 05; Vol. 13 (5), pp. 1584-1593. Date of Electronic Publication: 2023 Mar 05 (Print Publication: 2023).
Abstract: Purpose: It has been reported that brown adipose tissue (BAT) has a protective effect regarding cardiovascular disease. Positron emission tomography-computed tomography (PET-CT) is the reference method for detecting active BAT; however, it is not feasi...
Adipose-Renal Axis in Diabetic Nephropathy.
Publication Type: Academic Journal
Source(s): Current medicinal chemistry [Curr Med Chem] 2023; Vol. 30 (16), pp. 1860-1874.
Abstract: Long-term diabetes can lead to renal injury known as diabetic nephropathy (DN), which is a major cause of end-stage renal disease (ESRD). However, its pathogenesis has not been well explained. Adipose tissue is recognized as an important energy storage...
Eosinophils regulate intra-adipose axonal plasticity.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Jan 18; Vol. 119 (3).
Abstract: Sympathetic innervation regulates energy balance, and the nerve density in the adipose tissues changes under various metabolic states, resulting in altered neuronal control and conferring resilience to metabolic challenges. However, the impact of the i...
Human iPSC-Derived Proinflammatory Macrophages cause Insulin Resistance in an Isogenic White Adipose Tissue Microphysiological System.
Publication Type: Academic Journal
Source(s): Small (Weinheim an der Bergstrasse, Germany) [Small] 2023 Aug; Vol. 19 (34), pp. e2203725. Date of Electronic Publication: 2023 Apr 27.
Abstract: Chronic white adipose tissue (WAT) inflammation has been recognized as a critical early event in the pathogenesis of obesity-related disorders. This process is characterized by the increased residency of proinflammatory M1 macrophages in WAT. However, ...
The Transcription Factor HOXA5 : Novel Insights into Metabolic Diseases and Adipose Tissue Dysfunction.
Publication Type: Academic Journal
Source(s): Cells (2073-4409). Aug2023, Vol. 12 Issue 16, p2090. 14p.
Abstract: The transcription factor HOXA5, from the HOX gene family, has long been studied due to its critical role in physiological activities in normal cells, such as organ development and body patterning, and pathological activities in cancer cells. Nonetheles...
Effects of Dietary Inclusion of Asiaticoside on Growth Performance, Lipid Metabolism, and Gut Microbiota in Yellow-Feathered Chickens.
Publication Type: Academic Journal
Source(s): Animals (2076-2615). Aug2023, Vol. 13 Issue 16, p2653. 16p.
Abstract: Simple Summary: Excessive abdominal fat deposition is a pressing problem for the poultry industry as it increases the cost of meat production. Asiaticoside (Asi) is a herbal extract, and it was found that the dietary inclusion of Asi can significantly ...
鸢尾素在糖脂代谢相关疾病中的作用研究进展.
Publication Type: Academic Journal
Source(s): Chinese Journal of Arteriosclerosis. Aug2023, Vol. 31 Issue 8, p731-736. 6p.
Abstract: 鸢尾素主要是运动后由肌细胞产生及分泌的肌细胞因子,在脂肪组织、肝脏、胰腺、睾丸、胃等组织中也 有表达,其前体物质是Ⅲ型纤维连接蛋白结构域 5(FNDC5),经裂解后分泌到外周循环中。 鸢尾素通过 MAPK、 AMPK、PI3K/ Akt 及 STAT3 / Snail 等信号通路,促进白色脂肪组织棕色样变,增加线粒体代谢及能量消耗,改善胰岛 素抵抗,调节炎症因子、神经系统分化及成骨细胞增殖等,有望成为多种糖脂代谢相关疾病的新型治疗靶点。 [ABSTRACT FROM AUTHOR]...