Advanced Search Results For "ADP-ribosylation"
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STED imaging of endogenously tagged ARF GTPases reveals their distinct nanoscale localizations.
Publication Type: Academic Journal
Source(s): The Journal of cell biology [J Cell Biol] 2023 Jul 03; Vol. 222 (7). Date of Electronic Publication: 2023 Apr 27.
Abstract: ADP-ribosylation factor (ARF) GTPases are major regulators of cellular membrane homeostasis. High sequence similarity and multiple, possibly redundant functions of the five human ARFs make investigating their function a challenging task. To shed light ...
CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signalling.
Publication Type: Academic Journal
Source(s): Nature communications [Nat Commun] 2023 Jun 15; Vol. 14 (1), pp. 3560. Date of Electronic Publication: 2023 Jun 15.
Abstract: Cell motility is a critical feature of invasive tumour cells that is governed by complex signal transduction events. Particularly, the underlying mechanisms that bridge extracellular stimuli to the molecular machinery driving motility remain partially ...
The small molecule inhibitor NAV-2729 has a complex target profile including multiple ADP-ribosylation factor regulatory proteins.
Publication Type: Academic Journal
Source(s): The Journal of biological chemistry [J Biol Chem] 2023 Mar; Vol. 299 (3), pp. 102992. Date of Electronic Publication: 2023 Feb 08.
Abstract: The ADP-ribosylation factor (Arf) GTPases and their regulatory proteins are implicated in cancer progression. NAV-2729 was previously identified as a specific inhibitor of Arf6 that reduced progression of uveal melanoma in an orthotopic xenograft. Here...
Blocking the cytohesin-2/ARF1 axis by SecinH3 ameliorates osteoclast-induced bone loss via attenuating JNK-mediated IRE1 endoribonuclease activity.
Publication Type: Academic Journal
Source(s): Pharmacological research [Pharmacol Res] 2022 Nov; Vol. 185, pp. 106513. Date of Electronic Publication: 2022 Oct 14.
Abstract: cytohesin-2 is a guanine nucleotide exchange factor to activate ARF1 and ARF6, which are involved in various biological processes, including signal transduction, cell differentiation, cell structure organization, and survival. Nevertheless, there is a ...
AMPK promotes Arf6 activation in a kinase-independent manner upon glucose starvation.
Publication Type: Academic Journal
Source(s): Journal of cell science [J Cell Sci] 2022 Sep 15; Vol. 135 (18). Date of Electronic Publication: 2022 Sep 14.
Abstract: AMP-activated protein kinase (AMPK) is a crucial cellular nutrient and energy sensor that maintains energy homeostasis. AMPK also governs cancer cell invasion and migration by regulating gene expression and activating multiple cellular signaling pathwa...
Structural basis for activation of Arf1 at the Golgi complex.
Publication Type: Academic Journal
Source(s): Cell reports [Cell Rep] 2022 Aug 30; Vol. 40 (9), pp. 111282.
Abstract: The Golgi complex is the central sorting station of the eukaryotic secretory pathway. Traffic through the Golgi requires activation of Arf guanosine triphosphatases that orchestrate cargo sorting and vesicle formation by recruiting an array of effector...
Impact of Asp/Glu-ADP-ribosylation on protein-protein interaction and protein function.
Publication Type: Academic Journal
Source(s): Proteomics [Proteomics] 2023 Sep; Vol. 23 (17), pp. e2200083. Date of Electronic Publication: 2022 Dec 11.
Abstract: PARylation plays critical role in regulating multiple cellular processes such as DNA damage response and repair, transcription, RNA processing, and stress response. More than 300 human proteins have been found to be modified by PARylation on acidic res...
A chemical biology/modular antibody platform for ADP-ribosylation signaling.
Publication Type: Academic Journal
Source(s): Trends in biochemical sciences [Trends Biochem Sci] 2023 Oct; Vol. 48 (10), pp. 910-911. Date of Electronic Publication: 2023 Jun 30.
Abstract: Competing Interests: Declaration of interests H.D., E.J.L., and I.M. declare the following competing financial interests: Max-Planck-Innovation, the technology transfer center of the Max Planck Society, has licensed the antibodies AbD33204, AbD33205, A...
Arf1-PI4KIIIβ positive vesicles regulate PI(3)P signaling to facilitate lysosomal tubule fission.
Publication Type: Academic Journal
Source(s): The Journal of cell biology [J Cell Biol] 2023 Sep 04; Vol. 222 (9). Date of Electronic Publication: 2023 Jun 08.
Abstract: Formation and fission of tubules from autolysosomes, endolysosomes, or phagolysosomes are required for lysosome reformation. However, the mechanisms governing these processes in these different lysosomal organelles are poorly understood. Thus, the role...
ARF1 maintains intestinal homeostasis by modulating gut microbiota and stem cell function.
Publication Type: Academic Journal
Source(s): Life sciences [Life Sci] 2023 Sep 01; Vol. 328, pp. 121902. Date of Electronic Publication: 2023 Jun 29.
Abstract: Aims: The small GTPase protein ARF1 has been shown to be involved in the lipolysis pathway and to selectively kill stem cells in Drosophila melanogaster. However, the role of ARF1 in mammalian intestinal homeostasis remains elusive. This study aimed to...