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Torachrysone-8-O-β-d-glucoside mediates anti-inflammatory effects by blocking aldose reductase-catalyzed metabolism of lipid peroxidation products.
Publication Type: Academic Journal
Source(s): Biochemical pharmacology [Biochem Pharmacol] 2023 Dec; Vol. 218, pp. 115931. Date of Electronic Publication: 2023 Nov 18.
Abstract: Aldose reductase (AR) is an important enzyme involved in the reduction of various aldehyde and carbonyl compounds, including the highly reactive and toxic 4-hydroxynonenal (4-HNE), which has been linked to the progression of various pathologies such as...
Commentary: Aldehyde dehydrogenase, redox balance and exercise physiology: What is missing?
Publication Type: Academic Journal
Source(s): Comparative biochemistry and physiology. Part A, Molecular & integrative physiology [Comp Biochem Physiol A Mol Integr Physiol] 2023 Sep; Vol. 283, pp. 111470. Date of Electronic Publication: 2023 Jun 25.
Abstract: Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in reactive aldehyde detoxification. Approximately 560 million people (about 8% of the world's population) carry a point mutation in the aldehyde dehydrogenase 2 gene (ALDH2), identifi...
Aldehyde Dehydrogenase Genes as Prospective Actionable Targets in Acute Myeloid Leukemia.
Publication Type: Academic Journal
Source(s): Genes [Genes (Basel)] 2023 Sep 16; Vol. 14 (9). Date of Electronic Publication: 2023 Sep 16.
Abstract: It has been previously shown that the aldehyde dehydrogenase ( ALDH ) family member ALDH1A1 has a significant association with acute myeloid leukemia (AML) patient risk group classification and that AML cells lacking ALDH1A1 expression can be readily k...
Hypomethylation of Long Interspersed Nucleotide Elements and Aldehyde Dehydrogenase in Patients of Alcohol Use Disorder with Cirrhosis.
Publication Type: Academic Journal
Source(s): DNA and cell biology [DNA Cell Biol] 2023 Jul; Vol. 42 (7), pp. 364-371. Date of Electronic Publication: 2023 Jun 27.
Abstract: Alcohol use disorder (AUD) and cirrhosis are key outcomes of excessive alcohol use, and a genetic influence in these outcomes is increasingly recognized. While 80-90% of heavy alcohol users show evidence of fatty liver, only 10-20% progress to cirrhosi...
Leveraging intracellular ALDH1A1 activity for selective cancer stem-like cell labeling and targeted treatment via in vivo click reaction.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Sep 05; Vol. 120 (36), pp. e2302342120. Date of Electronic Publication: 2023 Aug 28.
Abstract: Inhibition of overexpressed enzymes is among the most promising approaches for targeted cancer treatment. However, many cancer-expressed enzymes are "nonlethal," in that the inhibition of the enzymes' activity is insufficient to kill cancer cells. Conv...
Electrocatalytic Aldehyde Oxidation by a Tungsten Dependent Aldehyde Oxidoreductase from Aromatoleum Aromaticum.
Publication Type: Academic Journal
Source(s): Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2023 Apr 06; Vol. 29 (20), pp. e202203072. Date of Electronic Publication: 2023 Mar 06.
Abstract: In contrast to their molybdenum dependent relatives, tungsten enzymes operate at significantly lower redox potentials, and in some cases they can carry out reversible redox transformations of their substrates and products. Still, the electrochemical pr...
Identifying the Molecular Drivers of Pathogenic Aldehyde Dehydrogenase Missense Mutations in Cancer and Non-Cancer Diseases.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jun 15; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 15.
Abstract: Human aldehyde dehydrogenases (ALDHs) comprising 19 isoenzymes play a vital role on both endogenous and exogenous aldehyde metabolism. This NAD(P)-dependent catalytic process relies on the intact structural and functional activity of the cofactor bindi...
A bacterial tungsten-containing aldehyde oxidoreductase forms an enzymatic decorated protein nanowire.
Publication Type: Academic Journal
Source(s): Science advances [Sci Adv] 2023 Jun 02; Vol. 9 (22), pp. eadg6689. Date of Electronic Publication: 2023 Jun 02.
Abstract: Aldehyde oxidoreductases (AORs) are tungsten enzymes catalyzing the oxidation of many different aldehydes to the corresponding carboxylic acids. In contrast to other known AORs, the enzyme from the denitrifying betaproteobacterium Aromatoleum aromaticu...
The History of Desulfovibrio gigas Aldehyde Oxidoreductase-A Personal View.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2023 May 22; Vol. 28 (10). Date of Electronic Publication: 2023 May 22.
Abstract: A story going back almost 40 years is presented in this manuscript. This is a different and more challenging way of reporting my research and I hope it will be useful to and target a wide-ranging audience. When preparing the manuscript and collecting r...
Combinatorial gene inactivation of aldehyde dehydrogenases mitigates aldehyde oxidation catalyzed by E. coli resting cells.
Publication Type: Academic Journal
Source(s): Metabolic engineering [Metab Eng] 2023 May; Vol. 77, pp. 294-305. Date of Electronic Publication: 2023 Apr 24.
Abstract: Aldehydes are attractive chemical targets both as end products in the flavors and fragrances industry and as synthetic intermediates due to their propensity for C-C bond formation. Here, we identify and address unexpected oxidation of a model collectio...