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Advanced Search Results For "ALZHEIMER'S disease"

1 - 10 of 283,293 results for
 "ALZHEIMER'S disease"
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Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer's disease.

Publication Type:Academic Journal

Source(s):Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2022 Sep; Vol. 104, pp. 154158. Date of Electronic Publication: 2022 May 13.

Abstract:Background: Based on the complex pathology of AD, a single chemical approach may not be sufficient to deal simultaneously with multiple pathways of amyloid-tau neuroinflammation. A polydrug approach which contains multiple bioactive components targetin...

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Alzheimer's disease amyloidogenesis is linked to altered lower urinary tract physiology.

Publication Type:Academic Journal

Source(s):Neurourology and urodynamics [Neurourol Urodyn] 2022 Aug; Vol. 41 (6), pp. 1344-1354. Date of Electronic Publication: 2022 May 17.

Abstract:Aims: While most Alzheimer's disease (AD) research emphasizes cognitive and behavioral abnormalities, lower urinary tract symptoms (LUTS) are observed in a third of AD patients, contributing to morbidity, poor quality of life, and need for institutiona...

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Differential spatial distribution of white matter lesions in Parkinson's and Alzheimer's diseases and cognitive sequelae.

Publication Type:Academic Journal

Source(s):Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2022 Aug; Vol. 129 (8), pp. 1023-1030. Date of Electronic Publication: 2022 Jul 11.

Abstract:White Matter Lesions (WML) are a radiological finding common in aged subjects. We explored the impact of WML on underlying neurodegenerative processes. We focused on the impact of WML on two neurodegenerative diseases with different pathology. In this ...

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Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model.

Publication Type:Academic Journal

Source(s):Journal of neuroinflammation [J Neuroinflammation] 2022 Jul 02; Vol. 19 (1), pp. 172. Date of Electronic Publication: 2022 Jul 02.

Abstract:Background: Deposition of amyloid beta (Aβ) and hyperphosphorylated tau along with glial cell-mediated neuroinflammation are prominent pathogenic hallmarks of Alzheimer's disease (AD). In recent years, impairment of autophagy has been identified as ano...

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C5aR1 antagonism alters microglial polarization and mitigates disease progression in a mouse model of Alzheimer's disease.

Publication Type:Academic Journal

Source(s):Acta neuropathologica communications [Acta Neuropathol Commun] 2022 Aug 17; Vol. 10 (1), pp. 116. Date of Electronic Publication: 2022 Aug 17.

Abstract:Multiple studies have recognized the involvement of the complement cascade during Alzheimer's disease pathogenesis. However, the specific role of C5a-C5aR1 signaling in the progression of this neurodegenerative disease is still not clear. Furthermore, ...

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Cryptotanshinone Alleviates Oxidative Stress and Reduces the Level of Abnormally Aggregated Protein in Caenorhabditis elegans AD Models.

Publication Type:Academic Journal

Source(s):International journal of molecular sciences [Int J Mol Sci] 2022 Sep 02; Vol. 23 (17). Date of Electronic Publication: 2022 Sep 02.

Abstract:Alzheimer's disease (AD) is one of the leading causes of dementia. As the first common neurodegenerative disease, there are no effective drugs that can reverse the progression. The present study is to report the anti-AD effect of cryptotanshinone (CTS)...

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Echinacoside Improves Cognitive Impairment by Inhibiting Aβ Deposition Through the PI3K/AKT/Nrf2/PPARγ Signaling Pathways in APP/PS1 Mice.

Publication Type:Academic Journal

Source(s):Molecular neurobiology [Mol Neurobiol] 2022 Aug; Vol. 59 (8), pp. 4987-4999. Date of Electronic Publication: 2022 Jun 04.

Abstract:Echinacoside (ECH), a phenylethanoid glycoside, has protective activity in neurodegenerative disease, including anti-inflammation and antioxidation. However, the effects of ECH in Alzheimer's disease (AD) are not very clear. This present study investig...

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Identification of cognitively impaired patients at risk for development of Alzheimer's disease dementia: an analysis of US Medicare claims data.

Publication Type:Academic Journal

Source(s):Expert review of pharmacoeconomics & outcomes research [Expert Rev Pharmacoecon Outcomes Res] 2022 Jul; Vol. 22 (5), pp. 773-786. Date of Electronic Publication: 2022 Mar 16.

Abstract:Background: Identifying factors associated with transitioning from mild cognitive impairment (MCI) to dementia due to Alzheimer's disease (AD dementia) or dementia due to any cause (all-cause dementia) may inform economic assessments of disease and ear...

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'Fly-ing' from rare to common neurodegenerative disease mechanisms.

Publication Type:Academic Journal

Source(s):Trends in genetics : TIG [Trends Genet] 2022 Sep; Vol. 38 (9), pp. 972-984. Date of Electronic Publication: 2022 Apr 25.

Abstract:Advances in genome sequencing have enabled researchers and clinicians to probe vast numbers of human variants to distinguish pathogenic from benign variants. Model organisms have been crucial in variant assessment and in delineating the molecular mecha...

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Frequency of Parkinson's Disease Genes and Role of PARK2 in Amyotrophic Lateral Sclerosis: An NGS Study.

Publication Type:Academic Journal

Source(s):Genes [Genes (Basel)] 2022 Jul 22; Vol. 13 (8). Date of Electronic Publication: 2022 Jul 22.

Abstract:Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) patients show a higher prevalence of Lewy body disease than the general population. Additionally, parkinsonian features were found in about 30% of ALS patients. We aimed to explore the fr...

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