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Multimodal mapping of cell types and projections in the central nucleus of the amygdala.

Publication Type: Academic Journal

Source(s): eLife. 2/28/2023, p1-33. 33p.

Abstract: The central nucleus of the amygdala (CEA) is a brain region that integrates external and internal sensory information and executes innate and adaptive behaviors through distinct output pathways. Despite its complex functions, the diversity of molecular...

Emotional learning retroactively promotes memory integration through rapid neural reactivation and reorganization.

Publication Type: Academic Journal

Source(s): eLife. 1/5/2023, p1-29. 29p.

Abstract: Neutral events preceding emotional experiences can be better remembered, likely by assigning them as significant to guide possible use in future. Yet, the neurobiological mechanisms of how emotional learning enhances memory for past mundane events rema...

Rostral and caudal basolateral amygdala engage distinct circuits in the prelimbic and infralimbic prefrontal cortex.

Publication Type: Academic Journal

Source(s): eLife. 12/30/2022, p1-23. 23p.

Abstract: Connections from the basolateral amygdala (BLA) to medial prefrontal cortex (PFC) regulate memory and emotion and become disrupted in neuropsychiatric disorders. The diverse roles attributed to interactions between the BLA and PFC may reflect multiple ...

An inhibitory circuit from central amygdala to zona incerta drives pain-related behaviors in mice.

Publication Type: Academic Journal

Source(s): eLife. 11/4/2022, p1-31. 31p.

Abstract: Central amygdala neurons expressing protein kinase C-delta (CeA-PKCδ) are sensitized following nerve injury and promote pain-related responses in mice. The neural circuits underlying modulation of pain-related behaviors by CeA-PKCδ neurons, however, re...

Synaptic location is a determinant of the detrimental effects of α-synuclein pathology to glutamatergic transmission in the basolateral amygdala.

Publication Type: Academic Journal

Source(s): eLife. 7/15/2022, p1-18. 18p.

Abstract: The presynaptic protein α-synuclein (αSyn) has been suggested to be involved in the pathogenesis of Parkinson's disease (PD). In PD, the amygdala is prone to develop insoluble αSyn aggregates, and it has been suggested that circuit dysfunction involvin...

Prefrontal-amygdalar oscillations related to social behavior in mice.

Publication Type: Academic Journal

Source(s): eLife. 5/17/2022, p1-22. 22p.

Abstract: The medial prefrontal cortex and amygdala are involved in the regulation of social behavior and associated with psychiatric diseases but their detailed neurophysiological mechanisms at a network level remain unclear. We recorded local field potentials ...

Electroacupuncture Reduces Fibromyalgia Pain by Attenuating the HMGB1, S100B, and TRPV1 Signalling Pathways in the Mouse Brain.

Publication Type: Academic Journal

Source(s): Evidence-based Complementary & Alternative Medicine (eCAM). 3/15/2022, p1-13. 13p. 5 Charts, 1 Graph.

Abstract: Fibromyalgia is characterized by chronic and persistent widespread pain and generalized muscle tenderness, and it is refractory to treatment. The central nervous system (CNS) plays an important role, pain signalling, in fibromyalgia subjects. Electroac...

Sleep fails to depotentiate amygdala-reactivity to negative emotional stimuli in youth with elevated symptoms of anxiety.

Publication Type: Academic Journal

Source(s): Cognitive, Affective & Behavioral Neuroscience. Apr2023, Vol. 23 Issue 2, p415-426. 12p.

Abstract: Sleep-related problems often precede escalating anxiety in early adolescence. Pushing beyond broad sleep-mental health associations and toward mechanistic theories of their interplay can inform etiological models of psychopathology. Recent studies sugg...

Longitudinal Associations between Peer and Family Relationships, Emotional Symptoms, and Regional Brain Volume across Adolescence.

Publication Type: Academic Journal

Source(s): Journal of Youth & Adolescence. Apr2023, Vol. 52 Issue 4, p734-753. 20p. 1 Diagram, 4 Charts, 1 Graph.

Abstract: The period of adolescence brings with it a dynamic interaction between social context and behaviour, structural brain development, and anxiety and depressive symptoms. The rate of volumetric change in the ventromedial prefrontal cortex (vmPFC) and amyg...

The importance of high quality real-life social interactions during the COVID-19 pandemic.

Publication Type: Academic Journal

Source(s): Scientific Reports. 3/4/2023, Vol. 13 Issue 1, p1-12. 12p.

Abstract: The coronavirus pandemic has brought about dramatic restrictions to real-life social interactions and a shift towards more online social encounters. Positive social interactions have been highlighted as an important protective factor, with previous stu...