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Advanced Search Results For "ANTINEOPLASTIC agents"

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 "ANTINEOPLASTIC agents"
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Evaluating the safety and effectiveness of PegaGen ® (pegfilgrastim) for the prevention of chemotherapy-induced febrile neutropenia: a post-marketing surveillance study.

Publication Type: Academic Journal

Source(s): Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2022 Oct; Vol. 30 (10), pp. 8151-8158. Date of Electronic Publication: 2022 Jul 06.

Abstract: Purpose: Phase IV clinical trials are required to evaluate the real-world safety and effectiveness of drugs. This study aimed to evaluate the safety and effectiveness of once-per-cycle administration of PegaGen ® (pegfilgrastim, CinnaGen, Iran) in canc...

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Teclistamab in Relapsed or Refractory Multiple Myeloma.

Publication Type: Academic Journal

Source(s): The New England journal of medicine [N Engl J Med] 2022 Aug 11; Vol. 387 (6), pp. 495-505. Date of Electronic Publication: 2022 Jun 05.

Abstract: Background: Teclistamab is a T-cell-redirecting bispecific antibody that targets both CD3 expressed on the surface of T cells and B-cell maturation antigen expressed on the surface of myeloma cells. In the phase 1 dose-defining portion of the study, te...

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Assessment of antitumor activity of BP-C1, a platinum-based anticancer agent with a lignin-derived polymeric ligand, in autochthonous induced and spontaneous carcinogenesis rodent models.

Publication Type: Academic Journal

Source(s): Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2022 Sep; Vol. 73, pp. 127013. Date of Electronic Publication: 2022 May 31.

Abstract: Background: A standard approach to study the anticancer activity of novel drugs is their testing in animals with inoculated tumors, which has some limitations. An alternative is the use of spontaneous or carcinogen-induced tumor models as they have bet...

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A phase 1 safety and bioimaging trial of antibody DS-8895a against EphA2 in patients with advanced or metastatic EphA2 positive cancers.

Publication Type: Academic Journal

Source(s): Investigational new drugs [Invest New Drugs] 2022 Aug; Vol. 40 (4), pp. 747-755. Date of Electronic Publication: 2022 Apr 11.

Abstract: Ephrin type-A 2 (EphA2) is a transmembrane receptor expressed in epithelial cancers. We report on a phase I dose escalation and biodistribution study of DS-8895a, an anti-EphA2 antibody, in patients with advanced EphA2 positive cancers. DS-8895a was ad...

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Serplulimab With Chemotherapy in Extensive-Stage SCLC.

Publication Type: Academic Journal

Source(s): JAMA [JAMA] 2022 Sep 27; Vol. 328 (12), pp. 1205-1207.

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Neoadjuvant Nivolumab plus Chemotherapy in Resectable Lung Cancer.

Publication Type: Academic Journal

Source(s): The New England journal of medicine [N Engl J Med] 2022 May 26; Vol. 386 (21), pp. 1973-1985. Date of Electronic Publication: 2022 Apr 11.

Abstract: Background: Neoadjuvant or adjuvant chemotherapy confers a modest benefit over surgery alone for resectable non-small-cell lung cancer (NSCLC). In early-phase trials, nivolumab-based neoadjuvant regimens have shown promising clinical activity; however,...

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In Vitro Anticancer Screening, Molecular Docking and Antimicrobial Studies of Triazole-Based Nickel(II) Metal Complexes.

Publication Type: Academic Journal

Source(s): Molecules (Basel, Switzerland) [Molecules] 2022 Oct 03; Vol. 27 (19). Date of Electronic Publication: 2022 Oct 03.

Abstract: Herein we describe the synthesis of a series of nickel(II) complexes (C1-C3) with Schiff bases (HL1-HL3) derived from 4-amino-5-mercapto-3-methyl-1,2,4-triazole and ortho/meta/para-nitrobenzaldehyde having composition [Ni(L) 2 (H 2 O) 2 ]. The obtained...

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Synthesis, Anticancer, Antioxidant, Anti-Inflammatory, Antimicrobial Activities, Molecular Docking, and DFT Studies of Sultams Derived from Saccharin.

Publication Type: Academic Journal

Source(s): Molecules (Basel, Switzerland) [Molecules] 2022 Oct 20; Vol. 27 (20). Date of Electronic Publication: 2022 Oct 20.

Abstract: A series of N -substituted saccharins namely 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2( 3H )-yl) acetonitrile ( 2 ) and (alkyl 1,1-dioxido-3-oxobenzo[d]isothiazol-2(3 H )-yl) acetate ( 3a - g ) were synthesized, in moderate to excellent yields, from com...

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Royal Jelly: Beneficial Properties and Synergistic Effects with Chemotherapeutic Drugs with Particular Emphasis in Anticancer Strategies.

Publication Type: Academic Journal

Source(s): Nutrients [Nutrients] 2022 Oct 07; Vol. 14 (19). Date of Electronic Publication: 2022 Oct 07.

Abstract: Cancer is one of the major causes of death globally. Currently, various methods are used to treat cancer, including radiotherapy, surgery, and chemotherapy, all of which have serious adverse effects. A healthy lifestyle, especially a nutritional diet, ...

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Quinoline-imidazole/benzimidazole derivatives as dual-/multi-targeting hybrids inhibitors with anticancer and antimicrobial activity.

Publication Type: Academic Journal

Source(s): Scientific reports [Sci Rep] 2022 Oct 10; Vol. 12 (1), pp. 16988. Date of Electronic Publication: 2022 Oct 10.

Abstract: Two new classes of hybrid quinoline-imidazole/benzimidazole derivatives (the hybrid QIBS salts and QIBC cycloadducts) were designed and synthesized to evaluate their anticancer and antimicrobial activity. The strategy adopted for synthesis is straight ...

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