scroll to top
0

EBSCO Auth Banner

Let's find your institution. Click here.

Advanced Search Results For "APOPTOSIS"

1 - 10 of 559,906 results for
 "APOPTOSIS"
Results per page:

(4-Picolylamino)-17β-Estradiol derivative and analogues induce apoptosis with death receptor trail R2/DR5 in MCF-7.

Publication Type: Academic Journal

Source(s): Chemico-biological interactions [Chem Biol Interact] 2023 Jan 05; Vol. 369, pp. 110286. Date of Electronic Publication: 2022 Nov 29.

Authors:

Abstract: In order to discover more effective and less toxic drugs in the field of anti-tumor, the backbone structure of 17β-estradiol was modified, and 11 target compounds were synthesized. Compounds 5 and 10, which exhibited better anti-tumor activity and high...

Escaping cell death via TRAIL decoy receptors: a systematic review of their roles and expressions in colorectal cancer.

Publication Type: Academic Journal

Source(s): Apoptosis : an international journal on programmed cell death [Apoptosis] 2022 Dec; Vol. 27 (11-12), pp. 787-799. Date of Electronic Publication: 2022 Oct 07.

Abstract: The development of targeted therapy such as tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-based therapy has gained increasing attention as a promising new approach in cancer therapy. TRAIL specifically targets cancer cells whil...

X-linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL.

Publication Type: Academic Journal

Source(s): EMBO molecular medicine [EMBO Mol Med] 2023 Jan 11; Vol. 15 (1), pp. e14557. Date of Electronic Publication: 2022 Nov 23.

Abstract: Acute lymphoblastic leukemia (ALL) represents the most frequent malignancy in children, and relapse/refractory (r/r) disease is difficult to treat, both in children and adults. In search for novel treatment options against r/r ALL, we studied inhibitor...

Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation.

Publication Type: Academic Journal

Source(s): Cell research [Cell Res] 2023 Feb; Vol. 33 (2), pp. 131-146. Date of Electronic Publication: 2023 Jan 06.

Authors:

Abstract: Members of the tumor necrosis factor receptor superfamily (TNFRSF) are important therapeutic targets that can be activated to induce death of cancer cells or stimulate proliferation of immune cells. Although it has long been implicated that these recep...

The interaction of CFLAR with p130Cas promotes cell migration.

Publication Type: Academic Journal

Source(s): Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2023 Feb; Vol. 1870 (2), pp. 119390. Date of Electronic Publication: 2022 Nov 16.

Authors:

Abstract: CASP8 and FADD Like Apoptosis Regulator (CFLAR) is a key anti-apoptotic regulator for resistance to apoptosis mediated by Fas and TRAIL. In addition to its anti-apoptotic function, CFLAR is also an important mediator of tumor growth. High level of CFLA...

Ras suppressor 1 long form (RSU1L) silencing promotes apoptosis in invasive breast cancer cells.

Publication Type: Academic Journal

Source(s): Cellular signalling [Cell Signal] 2023 Jan; Vol. 101, pp. 110522. Date of Electronic Publication: 2022 Nov 11.

Abstract: Ras Suppressor-1 (RSU1) is a cell-extracellular matrix (ECM) adhesion protein implicated in breast cancer (BC) cell metastasis. Nevertheless, its role in apoptosis is yet unknown. In the present study, we used bioinformatics tools to evaluate the assoc...

miR-208 inhibits myocardial tissues apoptosis in mice with acute myocardial infarction by targeting inhibition of PDCD4.

Publication Type: Academic Journal

Source(s): Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2022 Dec; Vol. 36 (12), pp. e23202. Date of Electronic Publication: 2022 Sep 09.

Authors:

Abstract: This article aimed to investigate the role of miR-208 in the apoptosis of myocardial tissues in acute myocardial infarction (AMI) mice. The AMI mouse model was constructed. Then, miR-208 expression in AMI mice was regulated by transfection. The mouse m...

Regulation of spermatogenic cell apoptosis by the pro-apoptotic proteins in the testicular tissues of mammalian and avian species.

Publication Type: Academic Journal

Source(s): Animal reproduction science [Anim Reprod Sci] 2022 Dec; Vol. 247, pp. 107158. Date of Electronic Publication: 2022 Nov 24.

Abstract: Apoptosis of germ cells is an important feature of spermatogenesis, as this process allows the removal of excess germ cells from testicular tissue. This is crucial to control the number of germ cells that can be supported and nourished by the Sertoli c...

Optimization of BAX trigger site activator BTSA1 with improved antitumor potency and in vitro ADMET properties.

Publication Type: Academic Journal

Source(s): European journal of medicinal chemistry [Eur J Med Chem] 2023 Feb 15; Vol. 248, pp. 115076. Date of Electronic Publication: 2023 Jan 10.

Authors:

Abstract: Direct activation of the pro-apoptotic protein BAX represents a potential therapeutic strategy to trigger apoptosis in cancer. Herein, structural optimization of the reported BAX trigger site activator BTSA1 turned out into a series of pyrazolone deriv...

Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism.

Publication Type: Academic Journal

Source(s): Chemico-biological interactions [Chem Biol Interact] 2023 Jan 05; Vol. 369, pp. 110278. Date of Electronic Publication: 2022 Nov 22.

Abstract: In recent years, studies have reported the role of stress-regulatory hormones, including epinephrine, in regulating the progression of a few cancers. However, the tumor-promoting action of epinephrine is not yet investigated in T cell malignancy, a rar...

sponsored