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Role of inhaled antibiotics in the era of highly effective CFTR modulators.
Publication Type: Academic Journal
Source(s): European respiratory review : an official journal of the European Respiratory Society [Eur Respir Rev] 2023 Jan 11; Vol. 32 (167). Date of Electronic Publication: 2023 Jan 11 (Print Publication: 2023).
Abstract: Recurrent and chronic bacterial infections are common in people with cystic fibrosis (CF) and contribute to lung function decline. Antibiotics are the mainstay in the treatment of exacerbations and chronic bacterial infection in CF. Inhaled antibiotics...
Controlling therapeutic protein expression via inhalation of a butter flavor molecule.
Publication Type: Academic Journal
Source(s): Nucleic acids research [Nucleic Acids Res] 2023 Mar 21; Vol. 51 (5), pp. e28.
Abstract: Precise control of the delivery of therapeutic proteins is critical for gene- and cell-based therapies, and expression should only be switched on in the presence of a specific trigger signal of appropriate magnitude. Focusing on the advantages of deliv...
Evaluation the efficacy and safety of N-acetylcysteine inhalation spray in controlling the symptoms of patients with COVID-19: An open-label randomized controlled clinical trial.
Publication Type: Academic Journal
Source(s): Journal of medical virology [J Med Virol] 2023 Jan; Vol. 95 (1), pp. e28393.
Abstract: The aim of this study was to evaluate the effect and safety of N-acetylcysteine (NAC) inhalation spray in the treatment of patients with coronavirus disease 2019 (COVID-19). This randomized controlled clinical trial study was conducted on patients with...
Sodium dichloroisocyanurate toxicity in rats during a 90-day inhalation toxicity study.
Publication Type: Academic Journal
Source(s): Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2022 Dec 01; Vol. 456, pp. 116279. Date of Electronic Publication: 2022 Oct 13.
Abstract: Sodium dichloroisocyanurate-96% (NaDCC) is commonly used to treat drinking water, industrial water, and wastewater. However, exposure to NaDCC by inhalation can have toxic pulmonary effects in humans. In the present study, we evaluated the potential to...
Considerations for Applying Route-to-Route Extrapolation to Assess the Safety of Oral Exposure to Substances.
Publication Type: Academic Journal
Source(s): Biomolecules [Biomolecules] 2022 Dec 20; Vol. 13 (1). Date of Electronic Publication: 2022 Dec 20.
Abstract: The safety evaluation of oral exposure to substances, such as food ingredients, additives, and their constituents, relies primarily on a careful evaluation and analysis of data from oral toxicity studies. When relevant oral toxicity studies are unavail...
Application of a new approach method (NAM) for inhalation risk assessment.
Publication Type: Academic Journal
Source(s): Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2022 Aug; Vol. 133, pp. 105216. Date of Electronic Publication: 2022 Jul 08.
Abstract: The US Environmental Protection Agency (USEPA) and other regulatory authorities have been working to utilize in vitro studies with human cells and in silico modelling to reduce the use of vertebrate animals for evaluating chemical risk. Using the Sourc...
Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial.
Publication Type: Academic Journal
Source(s): JAMA [JAMA] 2022 Jul 12; Vol. 328 (2), pp. 162-172.
Abstract: Importance: The optimal first-line mode of noninvasive respiratory support for acutely ill children is not known.Objective: To evaluate the noninferiority of high-flow nasal cannula therapy (HFNC) as the first-line mode of noninvasive respiratory suppo...
Evaluation of inhalation toxicology after a 90-day xylitol aerosol exposure in Sprague-Dawley rats.
Publication Type: Academic Journal
Source(s): Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2022 Jul 01; Vol. 446, pp. 116045. Date of Electronic Publication: 2022 May 05.
Abstract: Xylitol is a hygroscopic compound known to protect nasal cavity against bacteria. It has also been developed into nasal spray and evaluated as a potential candidate drug for respiratory diseases. Consequently, it is necessary to study its inhalation to...
Mechanistic modelling of targeted pulmonary delivery of dactinomycin iron oxide-loaded nanoparticles for lung cancer therapy.
Publication Type: Academic Journal
Source(s): Pharmaceutical development and technology [Pharm Dev Technol] 2022 Dec; Vol. 27 (10), pp. 1057-1068. Date of Electronic Publication: 2022 Dec 16.
Abstract: With the increase in respiratory conditions including lung cancer post covid-19 pandemic, drug-loaded nanoparticulate dry powder inhalers (DPIs) can facilitate targeted lung delivery as a patient-friendly, non-invasive method. The aim of this work was ...
Evaluation of the effectiveness and costs of inhaled methoxyflurane versus usual analgesia for prehospital injury and trauma: non-randomised clinical study.
Publication Type: Academic Journal
Source(s): BMC emergency medicine [BMC Emerg Med] 2022 Jul 07; Vol. 22 (1), pp. 122. Date of Electronic Publication: 2022 Jul 07.
Abstract: Background: We aimed to investigate clinical benefits and economic costs of inhaled methoxyflurane when used by ambulance staff for prehospital emergency patients with trauma. Comparison is to usual analgesic practice (UAP) in the UK in which patient r...