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Advanced Search Results For "Alzheimer's disease"

1 - 10 of 292,918 results for
 "Alzheimer's disease"
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Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer's disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathway.

Publication Type: Academic Journal

Source(s): Journal of neuroinflammation [J Neuroinflammation] 2023 Jan 30; Vol. 20 (1), pp. 19. Date of Electronic Publication: 2023 Jan 30.

Authors:

Abstract: Background: Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by progressive cognitive dysfunctions and behavioral impairments. Patchouli alcohol (PA), isolated from Pogostemonis Herba, exhibits multiple pharmacological prop...

Distinct effects of SDC3 and FGFRL1 on selective neurodegeneration in AD and PD.

Publication Type: Academic Journal

Source(s): FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2023 Feb; Vol. 37 (2), pp. e22773.

Authors:

Abstract: Alzheimer's disease (AD) and Parkinson's disease (PD) are age-dependent neurodegenerative disorders. There is a profound neuronal loss in the basal forebrain cholinergic system in AD and severe dopaminergic deficiency within the nigrostriatal pathway i...

Links between COVID-19 and Parkinson's disease/Alzheimer's disease: reciprocal impacts, medical care strategies and underlying mechanisms.

Publication Type: Academic Journal

Source(s): Translational neurodegeneration [Transl Neurodegener] 2023 Jan 30; Vol. 12 (1), pp. 5. Date of Electronic Publication: 2023 Jan 30.

Abstract: The impact of coronavirus disease 2019 (COVID-19) pandemic on patients with neurodegenerative diseases and the specific neurological manifestations of COVID-19 have aroused great interest. However, there are still many issues of concern to be clarified...

Knee osteoarthritis accelerates amyloid beta deposition and neurodegeneration in a mouse model of Alzheimer's disease.

Publication Type: Academic Journal

Source(s): Molecular brain [Mol Brain] 2023 Jan 02; Vol. 16 (1), pp. 1. Date of Electronic Publication: 2023 Jan 02.

Abstract: Knee osteoarthritis (OA) is characterized by knee cartilage degeneration and secondary bone hyperplasia, resulting in pain, stiffness, and gait disturbance. The relationship between knee OA and neurodegenerative diseases is still unclear. This study us...

Polygenic Liability to Alzheimer's Disease Is Associated with a Wide Range of Chronic Diseases: A Cohort Study of 312,305 Participants.

Publication Type: Academic Journal

Source(s): Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 91 (1), pp. 437-447.

Authors:

Abstract: Background: Alzheimer's disease (AD) patients rank among the highest levels of comorbidities compared to persons with other diseases. However, it is unclear whether the conditions are caused by shared pathophysiology due to the genetic pleiotropy for A...

Dopamine D2 receptor agonist Bromocriptine ameliorates Aβ 1-42 -induced memory deficits and neuroinflammation in mice.

Publication Type: Academic Journal

Source(s): European journal of pharmacology [Eur J Pharmacol] 2023 Jan 05; Vol. 938, pp. 175443. Date of Electronic Publication: 2022 Dec 02.

Authors:

Abstract: Alzheimer's Disease (AD) is the most common neurodegenerative disease, which lacks disease-modifying therapeutics so far. Studies have shown that the dysfunction of the dopaminergic system is related to a variety of pathophysiology of AD, and the expre...

SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers.

Publication Type: Academic Journal

Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Dec 13; Vol. 119 (50), pp. e2213157119. Date of Electronic Publication: 2022 Dec 09.

Abstract: The formation of toxic Amyloid β-peptide (Aβ) oligomers is one of the earliest events in the molecular pathology of Alzheimer's Disease (AD). These oligomers lead to a variety of downstream effects, including impaired neuronal signaling, neuroinflammat...

Discovery of novel imidazole chemotypes as isoform-selective JNK3 inhibitors for the treatment of Alzheimer's disease.

Publication Type: Academic Journal

Source(s): European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114894. Date of Electronic Publication: 2022 Nov 02.

Authors:

Abstract: Despite innumerable efforts to develop effective therapeutics, it is difficult to achieve breakthrough treatments for Alzheimer's disease (AD), and the main reason is probably the absence of a clear target. Here, we reveal c-Jun N-terminal kinase 3 (JN...

Boosting of tau protein aggregation by CD40 and CD48 gene expression in Alzheimer's disease.

Publication Type: Academic Journal

Source(s): FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2023 Jan; Vol. 37 (1), pp. e22702.

Authors:

Abstract: Neurodegenerative diseases result from the interplay of abnormal gene expression and various pathological factors. Therefore, a disease-specific integrative genetic approach is required to understand the complexities and causes of target diseases. Rece...

COVID-19 as a Risk Factor for Alzheimer's Disease.

Publication Type: Academic Journal

Source(s): Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2023; Vol. 91 (1), pp. 1-23.

Abstract: Severe acute respiratory disease coronavirus 2 (SARS-CoV-2) is responsible for the coronavirus disease 2019 (COVID-19) pandemic. Although a primarily respiratory disease, recent reports indicate that it also affects the central nervous system (CNS). Ov...

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