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Advanced Search Results For "Alzheimer's disease"

1 - 10 of 288,242 results for
 "Alzheimer's disease"
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Effects of α5 GABA A receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease.

Publication Type: Academic Journal

Source(s): CNS neuroscience & therapeutics [CNS Neurosci Ther] 2022 Nov; Vol. 28 (11), pp. 1767-1778. Date of Electronic Publication: 2022 Jul 13.

Abstract: Aims: GABAergic modulation involved in cognitive processing appears to be substantially changed in Alzheimer's disease (AD). In a widely used 5xFAD model of AD, we aimed to assess if negative and positive allosteric modulators of α5 GABA A receptors (N...

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Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer's disease.

Publication Type: Academic Journal

Source(s): Acta neuropathologica communications [Acta Neuropathol Commun] 2022 Sep 30; Vol. 10 (1), pp. 144. Date of Electronic Publication: 2022 Sep 30.

Abstract: Background: Regulatory T cells (Tregs) play a neuroprotective role by suppressing microglia and macrophage-mediated inflammation and modulating adaptive immune reactions. We previously documented that Treg immunomodulatory mechanisms are compromised in...

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Natural medicine HLXL targets multiple pathways of amyloid-mediated neuroinflammation and immune response in treating alzheimer's disease.

Publication Type: Academic Journal

Source(s): Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2022 Sep; Vol. 104, pp. 154158. Date of Electronic Publication: 2022 May 13.

Abstract: Background: Based on the complex pathology of AD, a single chemical approach may not be sufficient to deal simultaneously with multiple pathways of amyloid-tau neuroinflammation. A polydrug approach which contains multiple bioactive components targetin...

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Animal models of Alzheimer's disease: Applications, evaluation, and perspectives.

Publication Type: Academic Journal

Source(s): Zoological research [Zool Res] 2022 Nov 18; Vol. 43 (6), pp. 1026-1040.

Authors:

Abstract: Although great advances in elucidating the molecular basis and pathogenesis of Alzheimer's disease (AD) have been made and multifarious novel therapeutic approaches have been developed, AD remains an incurable disease. Evidence shows that AD neuropatho...

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Protective effect of pterostilbene in a streptozotocin-induced mouse model of Alzheimer's disease by targeting monoamine oxidase B.

Publication Type: Academic Journal

Source(s): Journal of applied toxicology : JAT [J Appl Toxicol] 2022 Nov; Vol. 42 (11), pp. 1777-1786. Date of Electronic Publication: 2022 Jun 16.

Authors:

Abstract: Alzheimer's disease (AD) is a neurodegenerative disease in elderly population. Pterostilbene (PTS) is a resveratrol analog with neuroprotective activity. However, the biological mechanisms of PTS in AD progression are largely uncertain. An animal model...

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Aquaporin-4 cerebrospinal fluid levels are higher in neurodegenerative dementia: looking at glymphatic system dysregulation.

Publication Type: Academic Journal

Source(s): Alzheimer's research & therapy [Alzheimers Res Ther] 2022 Sep 17; Vol. 14 (1), pp. 135. Date of Electronic Publication: 2022 Sep 17.

Abstract: Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of n...

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Cryptotanshinone Alleviates Oxidative Stress and Reduces the Level of Abnormally Aggregated Protein in Caenorhabditis elegans AD Models.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Sep 02; Vol. 23 (17). Date of Electronic Publication: 2022 Sep 02.

Authors:

Abstract: Alzheimer's disease (AD) is one of the leading causes of dementia. As the first common neurodegenerative disease, there are no effective drugs that can reverse the progression. The present study is to report the anti-AD effect of cryptotanshinone (CTS)...

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Pridopidine Promotes Synaptogenesis and Reduces Spatial Memory Deficits in the Alzheimer's Disease APP/PS1 Mouse Model.

Publication Type: Academic Journal

Source(s): Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics [Neurotherapeutics] 2022 Sep; Vol. 19 (5), pp. 1566-1587. Date of Electronic Publication: 2022 Aug 02.

Abstract: Sigma-1 receptor agonists have recently gained a great deal of interest due to their anti-amnesic, neuroprotective, and neurorestorative properties. Compounds such as PRE-084 or pridopidine (ACR16) are being studied as a potential treatment against cog...

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SYK coordinates neuroprotective microglial responses in neurodegenerative disease.

Publication Type: Academic Journal

Source(s): Cell [Cell] 2022 Oct 27; Vol. 185 (22), pp. 4135-4152.e22. Date of Electronic Publication: 2022 Oct 17.

Abstract: Recent studies have begun to reveal critical roles for the brain's professional phagocytes, microglia, and their receptors in the control of neurotoxic amyloid beta (Aβ) and myelin debris accumulation in neurodegenerative disease. However, the critical...

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Experimental and Clinical Biomarkers for Progressive Evaluation of Neuropathology and Therapeutic Interventions for Acute and Chronic Neurological Disorders.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Oct 03; Vol. 23 (19). Date of Electronic Publication: 2022 Oct 03.

Abstract: This article describes commonly used experimental and clinical biomarkers of neuronal injury and neurodegeneration for the evaluation of neuropathology and monitoring of therapeutic interventions. Biomarkers are vital for diagnostics of brain disease a...

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