Advanced Search Results For "Ataxia Telangiectasia Mutated Proteins"
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Rare Germline ATM Variants Influence the Development of Chronic Lymphocytic Leukemia.
Publication Type: Academic Journal
Source(s): Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2023 Feb 10; Vol. 41 (5), pp. 1116-1128. Date of Electronic Publication: 2022 Oct 31.
Abstract: Purpose: Germline missense variants of unknown significance in cancer-related genes are increasingly being identified with the expanding use of next-generation sequencing. The ataxia telangiectasia-mutated ( ATM ) gene on chromosome 11 has more than 1,...
Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity.
Publication Type: Academic Journal
Source(s): International journal of biological sciences [Int J Biol Sci] 2023 Jan 16; Vol. 19 (3), pp. 981-993. Date of Electronic Publication: 2023 Jan 16 (Print Publication: 2023).
Abstract: Although current cancer immunotherapies that target PD-1/PD-L1 immune checkpoint to reinvigorate exhausted T cells have achieved impressive clinical outcomes, only a small proportion of patients respond. New therapeutic targets are therefore needed to ...
Manipulation of Redox Metabolism Using Pharmacologic Ascorbate Opens a Therapeutic Window for Radio-Sensitization by ATM Inhibitors in Colorectal Cancer.
Publication Type: Academic Journal
Source(s): International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2023 Mar 15; Vol. 115 (4), pp. 933-944. Date of Electronic Publication: 2022 Oct 11.
Abstract: Purpose: Ataxia telangiectasia mutated kinase (ATM) inhibitors are potent radiosensitizers that regulate DNA damage responses and redox metabolism, but they have not been translated clinically because of the potential for excess normal tissue toxicity....
ATM-SPARK: A GFP phase separation-based activity reporter of ATM.
Publication Type: Academic Journal
Source(s): Science advances [Sci Adv] 2023 Mar; Vol. 9 (9), pp. eade3760. Date of Electronic Publication: 2023 Mar 01.
Abstract: The kinase ataxia telangiectasia mutated (ATM) plays a key role in the DNA damage response (DDR). It is thus essential to visualize spatiotemporal dynamics of ATM activity during DDR. Here, we designed a robust ATM activity reporter based on phosphoryl...
CRISPR metabolic screen identifies ATM and KEAP1 as targetable genetic vulnerabilities in solid tumors.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Feb 07; Vol. 120 (6), pp. e2212072120. Date of Electronic Publication: 2023 Feb 01.
Abstract: Cancer treatments targeting DNA repair deficiencies often encounter drug resistance, possibly due to alternative metabolic pathways that counteract the most damaging effects. To identify such alternative pathways, we screened for metabolic pathways exh...
Selective ATM inhibition augments radiation-induced inflammatory signaling and cancer cell death.
Publication Type: Academic Journal
Source(s): Aging [Aging (Albany NY)] 2023 Jan 17; Vol. 15 (2), pp. 492-512. Date of Electronic Publication: 2023 Jan 17.
Abstract: Over half of all cancer patients undergo radiation therapy but there is an unmet need for more efficacious combination strategies with molecular targeted drugs. DNA damage response has emerged as an important intervention point for improving anti-tumor...
Successful Treatment of Large B-Cell Lymphoma in a Child with Compound Heterozygous Mutation in the ATM Gene.
Publication Type: Report
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jan 06; Vol. 24 (2). Date of Electronic Publication: 2023 Jan 06.
Abstract: Ataxia-telangiectasia (AT) is a multisystemic neurodegenerative inborn error of immunity (IEI) characterized by DNA repair defect, chromosomal instability, and hypersensitivity to ionizing radiation. Impaired DNA double-strand break repair determines a...
Chronic arsenic exposure suppresses ATM pathway activation in human keratinocytes.
Publication Type: Academic Journal
Source(s): Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2022 Jul 01; Vol. 446, pp. 116042. Date of Electronic Publication: 2022 May 02.
Abstract: An estimated 220 million people worldwide are chronically exposed to inorganic arsenic (iAs) primarily as a result of drinking iAs-contaminated water. Chronic iAs exposure is associated with a plethora of human diseases including skin lesions and multi...
RYBP Sensitizes Cancer Cells to PARP Inhibitors by Regulating ATM Activity.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 Oct 04; Vol. 23 (19). Date of Electronic Publication: 2022 Oct 04.
Abstract: Ring1 and YY1 Binding Protein (RYBP) is a member of the non-canonical polycomb repressive complex 1 (PRC1), and like other PRC1 members, it is best described as a transcriptional regulator. Previously, we showed that RYBP, along with other PRC1 members...
Ovarian and uterine carcinosarcomas are sensitive in vitro and in vivo to elimusertib, a novel ataxia-telangiectasia and Rad3-related (ATR) kinase inhibitor.
Publication Type: Academic Journal
Source(s): Gynecologic oncology [Gynecol Oncol] 2023 Feb; Vol. 169, pp. 98-105. Date of Electronic Publication: 2022 Dec 14.
Abstract: Background: Carcinosarcoma of the ovary (OCS) and uterus (UCS) are rare highly aggressive malignancies. Ataxia-telangiectasia-and-Rad3-related (ATR) kinase and homologous recombination play a pivotal role in DNA damage repair. Homologous recombination ...