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Functional characterization of toxin-antitoxin system in Mycobacterium tuberculosis.
Publication Type: Academic Journal
Source(s): The Indian journal of tuberculosis [Indian J Tuberc] 2023 Apr; Vol. 70 (2), pp. 149-157. Date of Electronic Publication: 2022 May 27.
Abstract: Toxin-Antitoxin (TA) system is abundant in the microbial genome, especially in bacteria and archaea. Its genetic elements and addiction modules with the role of bacterial persistence and virulence. The TA system consists of a toxin and most unstable an...
A novel toxin-antitoxin system swpAB alters gene expression patterns and reduces virulence expression in enterohemorrhagic Escherichia coli.
Publication Type: Academic Journal
Source(s): Microbiology and immunology [Microbiol Immunol] 2023 Apr; Vol. 67 (4), pp. 171-184. Date of Electronic Publication: 2023 Feb 24.
Abstract: Toxin-antitoxin (TA) systems are found widely among many bacteria, including enterohemorrhagic Escherichia coli (EHEC), but their functions are still poorly understood. In this study, we identified and characterized a novel TA system belonging to the r...
Role of PumB antitoxin as a transcriptional regulator of the PumAB type-II toxin-antitoxin system and its endoribonuclease activity on the PumA (toxin) transcript.
Publication Type: Academic Journal
Source(s): Molecular genetics and genomics : MGG [Mol Genet Genomics] 2023 Mar; Vol. 298 (2), pp. 455-472. Date of Electronic Publication: 2023 Jan 05.
Abstract: The PumAB type-II toxin-antitoxin (TA) system is encoded by pumAB genes that are organized into an operon. This system is encoded by the pUM505 plasmid, isolated from a Pseudomonas aeruginosa clinical strain. The pumA gene encodes a putative RelE toxin...
Regulatory transcription factors of Clostridioides difficile pathogenesis with a focus on toxin regulation.
Publication Type: Academic Journal
Source(s): Critical reviews in microbiology [Crit Rev Microbiol] 2023 May; Vol. 49 (3), pp. 334-349. Date of Electronic Publication: 2022 Apr 07.
Abstract: Clostridioides difficile (CD), a nosocomial gut pathogen, produces two major exotoxins, TcdA and TcdB, which disrupt the gut epithelial barrier and induce inflammatory/immune responses, leading to symptoms ranging from mild diarrhoea to pseudomembranou...
Structural Basis for Binding of Neutralizing Antibodies to Clostridioides difficile Binary Toxin.
Publication Type: Academic Journal
Source(s): Journal of bacteriology [J Bacteriol] 2023 Apr 25; Vol. 205 (4), pp. e0045622. Date of Electronic Publication: 2023 Mar 23.
Abstract: Clostridioides difficile is a Gram-positive opportunistic human pathogen that causes 15,000 deaths annually in the United States, prompting a need for vaccine development. In addition to the important toxins TcdA and TcdB, binary toxin (CDT) plays a si...
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S N i Mechanism and Ion Pair Transition State.
Publication Type: Academic Journal
Source(s): ACS chemical biology [ACS Chem Biol] 2022 Sep 16; Vol. 17 (9), pp. 2507-2518. Date of Electronic Publication: 2022 Aug 29.
Abstract: Toxins TcdA and TcdB from Clostridioides difficile glucosylate human colon Rho GTPases. TcdA and TcdB glucosylation of RhoGTPases results in cytoskeletal changes, causing cell rounding and loss of intestinal integrity. Clostridial toxins TcdA and TcdB ...
A leaky human colon model reveals uncoupled apical/basal cytotoxicity in early Clostridioides difficile toxin exposure.
Publication Type: Academic Journal
Source(s): American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2023 Apr 01; Vol. 324 (4), pp. G262-G280. Date of Electronic Publication: 2023 Feb 07.
Abstract: Clostridioides difficile ( C. difficile ) toxins A (TcdA) and B (TcdB) cause antibiotic-associated colitis in part by disrupting epithelial barrier function. Accurate in vitro models are necessary to detect early toxicity kinetics, investigate disease ...
AAV-mediated delivery of actoxumab and bezlotoxumab results in serum and mucosal antibody concentrations that provide protection from C. difficile toxin challenge.
Publication Type: Academic Journal
Source(s): Gene therapy [Gene Ther] 2023 May; Vol. 30 (5), pp. 455-462. Date of Electronic Publication: 2021 Feb 19.
Abstract: Clostridium difficile is the leading cause of antibiotic-associated nosocomial diarrhea in the developed world. When the host-associated colon microbiome is disrupted by the ingestion of antibiotics, C. difficile spores can germinate, resulting in infe...
Prevalence, genetic characteristics, and antimicrobial resistance of Clostridioides difficile isolates from horses in Korea.
Publication Type: Academic Journal
Source(s): Anaerobe [Anaerobe] 2023 Apr; Vol. 80, pp. 102700. Date of Electronic Publication: 2023 Jan 27.
Abstract: Objectives: Clostridioides difficile is an etiological agent of enteric diseases in humans and animals. Animals are considered a potential reservoir due to the genetic and antimicrobial resistance similarities between human and animal C. difficile isol...
Cyanotoxin exposure and hepatocellular carcinoma.
Publication Type: Academic Journal
Source(s): Toxicology [Toxicology] 2023 Mar 15; Vol. 487, pp. 153470. Date of Electronic Publication: 2023 Feb 28.
Abstract: Cyanobacteria are ubiquitous in aquatic and terrestrial environments worldwide and include a number of species producing tumor-promoting hepatotoxins. Human exposure to cyanobacteria and cyanotoxins primarily occurs though ingestion of contaminated dri...