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Advanced Search Results For "BIOPHARMACEUTICS"

1 - 10 of 13,743 results for
 "BIOPHARMACEUTICS"
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Biopharmaceutics studies applied to goyazensolide: a drug candidate from Lychnophora species.

Publication Type:Academic Journal

Source(s):The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2022 Aug 19; Vol. 74 (8), pp. 1140-1151.

Abstract:Objectives: To predict the substance's behaviour in vivo and determine the viability of the bioactive substance to become a drug, this work aimed to evaluate the biopharmaceutics characteristics of goyazensolide.Methods: Differential scanning calorimet...

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The Use of Physiologically Based Pharmacokinetic Analyses-in Biopharmaceutics Applications -Regulatory and Industry Perspectives.

Publication Type:Academic Journal

Source(s):Pharmaceutical research [Pharm Res] 2022 Aug; Vol. 39 (8), pp. 1681-1700. Date of Electronic Publication: 2022 May 18.

Abstract:The use of physiologically based pharmacokinetic (PBPK) modeling to support the drug product quality attributes, also known as physiologically based biopharmaceutics modeling (PBBM) is an evolving field and the interest in using PBBM is increasing. The...

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iBCS: 2. Mechanistic Modeling of Pulmonary Availability of Inhaled Drugs versus Critical Product Attributes.

Publication Type:Academic Journal

Source(s):Molecular pharmaceutics [Mol Pharm] 2022 Jul 04; Vol. 19 (7), pp. 2040-2047. Date of Electronic Publication: 2022 May 24.

Abstract:This work is the second in a series of publications outlining the fundamental principles and proposed design of a biopharmaceutics classifications system for inhaled drugs and drug products (the iBCS). Here, a mechanistic computer-based model has been ...

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iBCS: 1. Principles and Framework of an Inhalation-Based Biopharmaceutics Classification System.

Publication Type:Academic Journal

Source(s):Molecular pharmaceutics [Mol Pharm] 2022 Jul 04; Vol. 19 (7), pp. 2032-2039. Date of Electronic Publication: 2022 May 16.

Abstract:For oral drugs, the formulator and discovery chemist have a tool available to them that can be used to navigate the risks associated with the selection and development of immediate release oral drugs and drug products. This tool is the biopharmaceutics...

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Application of physiologically based absorption and pharmacokinetic modeling in the development process of oral modified release generic products.

Publication Type:Academic Journal

Source(s):European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2022 Jul; Vol. 176, pp. 87-94. Date of Electronic Publication: 2022 May 19.

Abstract:Physiologically based pharmacokinetic (PBPK) modeling for biopharmaceutics applications holds great promise as modelling and simulation tool in the field of modern oral modified release (MR) products. Understanding of gastro-intestinal absorption relat...

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Voices in Molecular Pharmaceutics: Meet Dr. Yongchao Su, Innovating at the Molecular Level.

Publication Type:Editorial & Opinion

Source(s):Molecular pharmaceutics [Mol Pharm] 2022 Sep 05; Vol. 19 (9), pp. 3005-3006. Date of Electronic Publication: 2022 Aug 19.

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An Enabling Formulation of a Weakly Basic Compound Guided by Physiologically Based Biopharmaceutics Modeling (PBBM).

Publication Type:Academic Journal

Source(s):Journal of pharmaceutical sciences [J Pharm Sci] 2022 Sep; Vol. 111 (9), pp. 2490-2495. Date of Electronic Publication: 2022 Apr 16.

Abstract:Weakly basic compounds propose biopharmaceutics risks due to the possibility of precipitation out of solution when passing from the stomach to the intestine. This behavior would limit the available drug for absorption and in turn reduces the plasma exp...

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Voices in Molecular Pharmaceutics: Meet Dr. Paroma Chakravarty, a Solid-State Detective Investigating Which Polymorphs Are Developable.

Publication Type:Editorial & Opinion

Source(s):Molecular pharmaceutics [Mol Pharm] 2022 Aug 01; Vol. 19 (8), pp. 2686-2687. Date of Electronic Publication: 2022 Jul 06.

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Voices in Molecular Pharmaceutics: Meet Dr. Vilmalí López-Mejías Who Finds Well-Behaved Solid-State Forms for Drug Development.

Publication Type:Editorial & Opinion

Source(s):Molecular pharmaceutics [Mol Pharm] 2022 Aug 01; Vol. 19 (8), pp. 2688-2689. Date of Electronic Publication: 2022 Jun 17.

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Soluplus ® polymeric nanomicelles improve solubility of BCS-class II drugs.

Publication Type:Academic Journal

Source(s):Drug delivery and translational research [Drug Deliv Transl Res] 2022 Aug; Vol. 12 (8), pp. 1991-2006. Date of Electronic Publication: 2022 May 23.

Abstract:The issue of poor aqueous solubility is often a great hitch in the development of liquid dosage forms for those drugs that the Biopharmaceutics Classification System (BCS) includes in classes II and IV. Among the possible technological solutions, inclu...

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