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Advanced Search Results For "BRAIN diseases"

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 "BRAIN diseases"
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Optimized integration of metabolomics and lipidomics reveals brain region-specific changes of oxidative stress and neuroinflammation in type 1 diabetic mice with cognitive decline.

Publication Type: Academic Journal

Source(s): Journal of advanced research [J Adv Res] 2023 Jan; Vol. 43, pp. 233-245. Date of Electronic Publication: 2022 Feb 22.

Authors:

Abstract: Introduction: Type 1 diabetes (T1D) causes cognitive decline and has been associated with brain metabolic disorders, but its potential molecular mechanisms remain unclear.Objectives: The purpose of this study was to explore the molecular mechanisms und...

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Intracerebroventricular dosing of N-sulfoglucosamine sulfohydrolase in mucopolysaccharidosis IIIA mice reduces markers of brain lysosomal dysfunction.

Publication Type: Academic Journal

Source(s): The Journal of biological chemistry [J Biol Chem] 2022 Dec; Vol. 298 (12), pp. 102625. Date of Electronic Publication: 2022 Oct 26.

Abstract: Mucopolysaccharidosis type IIIA (MPS IIIA) is a lysosomal storage disorder caused by N-sulfoglucosamine sulfohydrolase (SGSH) deficiency. SGSH removes the sulfate from N-sulfoglucosamine residues on the nonreducing end of heparan sulfate (HS-NRE) withi...

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Brain cell signaling abnormalities are detected in blood in a murine model of Fragile X syndrome and corrected by Sigma-1 receptor agonist Blarcamesine.

Publication Type: Report

Source(s): American journal of medical genetics. Part A [Am J Med Genet A] 2022 Aug; Vol. 188 (8), pp. 2497-2500. Date of Electronic Publication: 2022 Jun 04.

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A novel generation adversarial network framework with characteristics aggregation and diffusion for brain disease classification and feature selection.

Publication Type: Academic Journal

Source(s): Briefings in bioinformatics [Brief Bioinform] 2022 Nov 19; Vol. 23 (6).

Authors:

Abstract: Imaging genetics provides unique insights into the pathological studies of complex brain diseases by integrating the characteristics of multi-level medical data. However, most current imaging genetics research performs incomplete data fusion. Also, the...

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Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction.

Publication Type: Academic Journal

Source(s): Journal of hepatology [J Hepatol] 2023 Jan; Vol. 78 (1), pp. 180-190. Date of Electronic Publication: 2022 Aug 19.

Abstract: Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has been associated with mild cerebral dysfunction and cognitive decline, although the exact pathophysiological mechanism remains ambiguous. Using a diet-induced model of NAFLD and monocarbox...

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Identifying encephalopathies from acute metabolic derangements.

Publication Type: Academic Journal

Source(s): Journal of internal medicine [J Intern Med] 2022 Dec; Vol. 292 (6), pp. 846-857. Date of Electronic Publication: 2022 Jul 09.

Authors:

Abstract: Metabolic derangements, when acute and severe, affect brain function. This presents mostly with a marked decline in the level of consciousness, resulting in impaired responsiveness, abnormal receptivity, impaired content, and loss of memory retention. ...

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Teaching NeuroImage: Primary Familial Brain Calcification in SLC20A2 Genotype.

Publication Type: Academic Journal

Source(s): Neurology [Neurology] 2022 Nov 29; Vol. 99 (22), pp. 1008-1009. Date of Electronic Publication: 2022 Sep 20.

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Emerging Materials, Wearables, and Diagnostic Advancements in Therapeutic Treatment of Brain Diseases.

Publication Type: Academic Journal

Source(s): Biosensors [Biosensors (Basel)] 2022 Dec 16; Vol. 12 (12). Date of Electronic Publication: 2022 Dec 16.

Abstract: Among the most critical health issues, brain illnesses, such as neurodegenerative conditions and tumors, lower quality of life and have a significant economic impact. Implantable technology and nano-drug carriers have enormous promise for cerebral brai...

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Ultrasound-mediated blood-brain barrier opening: An effective drug delivery system for theranostics of brain diseases.

Publication Type: Academic Journal

Source(s): Advanced drug delivery reviews [Adv Drug Deliv Rev] 2022 Nov; Vol. 190, pp. 114539. Date of Electronic Publication: 2022 Sep 15.

Authors:

Abstract: Blood-brain barrier (BBB) remains a significant obstacle to drug therapy for brain diseases. Focused ultrasound (FUS) combined with microbubbles (MBs) can locally and transiently open the BBB, providing a potential strategy for drug delivery across the...

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New insight into brain disease therapy: nanomedicines-crossing blood-brain barrier and extracellular space for drug delivery.

Publication Type: Academic Journal

Source(s): Expert opinion on drug delivery [Expert Opin Drug Deliv] 2022 Dec; Vol. 19 (12), pp. 1618-1635. Date of Electronic Publication: 2022 Oct 31.

Authors:

Abstract: Introduction: Brain diseases including brain tumor, Alzheimer's disease, Parkinson's disease, etc. are difficult to treat. The blood-brain barrier (BBB) is a major obstacle for drug delivery into the brain. Although nano-package and receptor-mediated d...

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