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Extracellular Lactic Acidosis of the Tumor Microenvironment Drives Adipocyte-to-Myofibroblast Transition Fueling the Generation of Cancer-Associated Fibroblasts.
Publication Type: Academic Journal
Source(s): Cells [Cells] 2023 Mar 20; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 20.
Abstract: Lactic acidosis characterizes the tumor microenvironment (TME) and is involved in the mechanisms leading to cancer progression and dissemination through the reprogramming of tumor and local host cells (e.g., endothelial cells, fibroblasts, and immune c...
Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling.
Publication Type: Academic Journal
Source(s): Cellular & molecular immunology [Cell Mol Immunol] 2022 Dec; Vol. 19 (12), pp. 1373-1391. Date of Electronic Publication: 2022 Oct 14.
Abstract: The interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and metastasis. Cancer-associated fibroblasts (CAFs) play a crucial role in promoting these events through paracrine communication. Here, we demons...
CAFs and Cancer Cells Co-Migration in 3D Spheroid Invasion Assay.
Publication Type: Academic Journal
Source(s): Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2179, pp. 243-256.
Abstract: In many solid tumors, collective cell invasion prevails over single-cell dissemination strategies. Collective modes of invasion often display specific front/rear cellular organization, where invasive leader cells arise from cancer cell populations or t...
Size and Morphology-Mediated Antiproliferative Activity of Hydroxyapatite Nanoparticles in Human Breast Cancer Cells.
Publication Type: Academic Journal
Source(s): Journal of Nanotechnology. 4/18/2023, p1-8. 8p.
Abstract: Hydroxyapatite nanoparticles (nHAPs) have been recognized for potent antitumor effects in certain cancer cells, making them good candidates as drug delivery agents and tumor therapeutics with fewer than normal side effects. This study is aimed to corre...
circSPECC1 Promotes Proliferation and Migration of LNCaP Prostate Cancer Cells by Affecting Their Epithelial-Mesenchymal Transition.
Publication Type: Academic Journal
Source(s): Journal of Immunology Research. 3/27/2023, p1-8. 8p. 1 Chart, 3 Graphs.
Abstract: Objective. To determine the effects of circSPECC1 (hsa_circ_0000745) on the proliferation and migration of LNCaP prostate cancer cells and to explore the potential molecular mechanism. Methods. Stable circSPECC1 shRNA-expressing and circSPECC1-overexpr...
miR-19-3p Targets PTEN to Regulate Cervical Cancer Cell Proliferation, Invasion, and Autophagy.
Publication Type: Academic Journal
Source(s): Genetics Research. 3/3/2023, Vol. 2023, p1-8. 8p.
Abstract: Background. Cervical cancer is the second most common cancer among women worldwide. Extensive studies have shown that microRNAs (miRNA/miR) can regulate the formation, progression, and metastasis of cancer. The purpose of this study was to investigate ...
Cancer-Associated Fibroblasts Differentiated by Exosomes Isolated from Cancer Cells Promote Cancer Cell Invasion.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2020 Oct 31; Vol. 21 (21). Date of Electronic Publication: 2020 Oct 31.
Abstract: Cancer-associated fibroblasts (CAFs) in the cancer microenvironment play an essential role in metastasis. Differentiation of endothelial cells into CAFs is induced by cancer cell-derived exosomes secreted from cancer cells that transfer molecular signa...
Cytotoxicity screening of some Turkish plants against renal cancer cells.
Publication Type: Academic Journal
Source(s): Journal of Research in Pharmacy. 2023, Vol. 27 Issue 2, p636-641. 6p.
Abstract: In this contribution, we performed cytotoxicity screening of 51 extracts from 17 plant species, representing 14 families growing in Turkey. Cytotoxic activities of the dichloromethane, ethyl acetate, and methanol extracts of the plants were investigate...
Radiosensitivity Enhancement using Triptorelin Conjugated Bismuth Sulfide Nanoparticles (Bi2S3@BSA) in Radiotherapy for Breast Cancer Cells.
Publication Type: Academic Journal
Source(s): Journal of Nanomaterials. 5/6/2023, p1-11. 11p.
Abstract: The aim of this study was to assess the radiosensitivity of bismuth sulfide nanoparticles conjugated with a synthetic agonist analog of gonadotropin-releasing hormones in targeted radiotherapy for breast cancer. After synthesis and characterization of ...
Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion.
Publication Type: Academic Journal
Source(s): eLife. 4/3/2023, p1-24. 24p.
Abstract: Pancreatic ductal adenocarcinoma (PDAC) continues to show no improvement in survival rates. One aspect of PDAC is elevated ATP levels, pointing to the purinergic axis as a potential attractive therapeutic target. Mediated in part by highly druggable ex...