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Investigating the Role of Tumor-Infiltrating Lymphocytes as Predictors of Lymph Node Metastasis in Deep Submucosal Invasive Colorectal Cancer: A Retrospective Cross-Sectional Study.
Publication Type: Academic Journal
Source(s): Cancers. Nov2023, Vol. 15 Issue 21, p5238. 15p.
Abstract: Simple Summary: In advanced colorectal cancer (CRC), tumor-infiltrating T cells (TILs) are reportedly associated with lymph node (LN) metastasis and prognosis. However, there are no reports focusing on early-stage CRC or examining changes in TILs accor...
Functional Proteomics Characterization of the Role of SPRYD7 in Colorectal Cancer Progression and Metastasis.
Publication Type: Academic Journal
Source(s): Cells (2073-4409). Nov2023, Vol. 12 Issue 21, p2548. 25p.
Abstract: SPRY domain-containing protein 7 (SPRYD7) is a barely known protein identified via spatial proteomics as being upregulated in highly metastatic-to-liver KM12SM colorectal cancer (CRC) cells in comparison to its isogenic poorly metastatic KM12C CRC cell...
Molecular Mechanisms of Tumor Progression and New Therapeutic Strategies for Urological Cancers.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Nov2023, Vol. 24 Issue 21, p15795. 5p.
Abstract: This document is an editorial from the International Journal of Molecular Sciences that focuses on the molecular mechanisms of tumor progression and new therapeutic strategies for urological cancers. Urological cancers, including bladder, prostate, ren...
Role of UBE2C in Brain Cancer Invasion and Dissemination.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Nov2023, Vol. 24 Issue 21, p15792. 17p.
Abstract: Glioblastoma (GB) and brain metastases (BM) are the most common brain tumors in adults and are invariably associated with a dismal outcome. These highly malignant tumors share common features including increased invasion and migration of the primary or...
Chlorahololide D, a Lindenane-Type Sesquiterpenoid Dimer from Chloranthus holostegius Suppressing Breast Cancer Progression.
Publication Type: Academic Journal
Source(s): Molecules. Oct2023, Vol. 28 Issue 20, p7070. 12p.
Abstract: Aimed at discovering small molecules as anticancer drugs or lead compounds from plants, a lindenane-type sesquiterpene dimer, chlorahololide D, was isolated from Chloranthus holostegius. The literature review showed that there were few reports on the a...
Tumor Progression from a Fibroblast Activation Protein Perspective: Novel Diagnostic and Therapeutic Scenarios for Colorectal Cancer.
Publication Type: Academic Journal
Source(s): Diagnostics (2075-4418). Oct2023, Vol. 13 Issue 20, p3199. 14p.
Abstract: In 2020, the Global Cancer Observatory estimated the incidence of colorectal cancer (CRC) at around 10.7% coupled with a mortality rate of 9.5%. The explanation for these values lies in the tumor microenvironment consisting of the extracellular matrix ...
HHV-6A Infection of Papillary Thyroid Cancer Cells Induces Several Effects Related to Cancer Progression.
Publication Type: Academic Journal
Source(s): Viruses (1999-4915). Oct2023, Vol. 15 Issue 10, p2122. 12p.
Abstract: Recent studies have shown that thyrocytes are permissive to HHV-6A infection and that the virus may contribute to the pathogenesis of autoimmune thyroiditis. Thyroid autoimmune diseases increase the risk of papillary cancer, which is not surprising con...
Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression.
Publication Type: Academic Journal
Source(s): Genes. Oct2023, Vol. 14 Issue 10, p1953. 29p.
Abstract: Metabolism and the immunological state are intimately intertwined, as defense responses are bioenergetically expensive. Metabolic homeostasis is a key requirement for the proper function of immune cell subsets, and the perturbation of the immune–metabo...
A Narrative Review on CD44's Role in Glioblastoma Invasion, Proliferation, and Tumor Recurrence.
Publication Type: Academic Journal
Source(s): Cancers. Oct2023, Vol. 15 Issue 19, p4898. 25p.
Abstract: Simple Summary: As recurrence in glioblastoma is locally generated around the resection cavity, surviving glioma stem-like cells may cause recurrence. Glioma stem-like cells expressing high levels of CD44 are highly invasive and are required to change ...
BMSC–HNC Interaction: Exploring Effects on Bone Integrity and Head and Neck Cancer Progression.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Oct2023, Vol. 24 Issue 19, p14417. 12p.
Abstract: In recent research, the tumor microenvironment has been shown to attract mesenchymal stromal cells (MSCs), which is of particular interest due to its implications for cancer progression. The study focused on understanding the interaction between bone m...