Advanced Search Results For "CATHEPSIN B"
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Some morpholine tethered novel aurones: Design, synthesis, biological, kinetic and molecular docking studies.
Publication Type: Academic Journal
Source(s): Bioorganic chemistry [Bioorg Chem] 2023 Nov; Vol. 140, pp. 106805. Date of Electronic Publication: 2023 Aug 22.
Abstract: Enzymes are the biological macromolecules that have emerged as an important drug target as their upregulation/imbalance leads to various pathological conditions, such as inflammation, parasitic infection, Alzheimer's, cancer, and many others. Here, we ...
Impact of Enniatin B and Beauvericin on Lysosomal Cathepsin B Secretion and Apoptosis Induction.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jan 19; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 19.
Abstract: Enniatin B (ENN B) and Beauvericin (BEA) are cyclohexadepsipeptides that can be isolated from Fusarium and Beauveria bassiana , respectively. Both compounds are cytotoxic and ionophoric. In the present study, the mechanism of cell death induced by thes...
Subnanomolar Cathepsin S Inhibitors with High Selectivity: Optimizing Covalent Reversible α-Fluorovinylsulfones and α-Sulfonates as Potential Immunomodulators in Cancer.
Publication Type: Academic Journal
Source(s): ChemMedChem [ChemMedChem] 2023 Aug 01; Vol. 18 (15), pp. e202300160. Date of Electronic Publication: 2023 Jun 01.
Abstract: The cysteine protease cathepsin S (CatS) is overexpressed in many tumors. It is known to be involved in tumor progression as well as antigen processing in antigen-presenting cells (APC). Recent evidence suggests that silencing CatS improves the anti-tu...
Human Mast Cells Upregulate Cathepsin B, a Novel Marker of Itch in Psoriasis.
Publication Type: Academic Journal
Source(s): Cells [Cells] 2023 Aug 30; Vol. 12 (17). Date of Electronic Publication: 2023 Aug 30.
Abstract: Mast cells (MCs) contribute to skin inflammation. In psoriasis, the activation of cutaneous neuroimmune networks commonly leads to itch. To dissect the unique contribution of MCs to the cutaneous neuroinflammatory response in psoriasis, we examined the...
The secretory ability of newly formed secretory granules is regulated by pro-cathepsin B and amylase in parotid glands.
Publication Type: Academic Journal
Source(s): Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2023 Jul 23; Vol. 666, pp. 45-51. Date of Electronic Publication: 2023 May 05.
Abstract: Parotid glands are exocrine glands that release saliva into the oral cavity. Acinar cells of parotid glands produce many secretory granules (SGs) that contain the digestion enzyme amylase. After the generation of SGs in the Golgi apparatus, they mature...
Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis.
Publication Type: Academic Journal
Source(s): Cell research [Cell Res] 2023 Jul; Vol. 33 (7), pp. 546-561. Date of Electronic Publication: 2023 May 08.
Abstract: Genetic information is generally transferred from RNA to protein according to the classic "Central Dogma". Here, we made a striking discovery that post-translational modification of a protein specifically regulates the editing of its own mRNA. We show ...
Distinct Cleavage Properties of Cathepsin B Compared to Cysteine Cathepsins Enable the Design and Validation of a Specific Substrate for Cathepsin B over a Broad pH Range.
Publication Type: Academic Journal
Source(s): Biochemistry [Biochemistry] 2023 Aug 01; Vol. 62 (15), pp. 2289-2300. Date of Electronic Publication: 2023 Jul 17.
Abstract: The biological and pathological functions of cathepsin B occur in acidic lysosomes and at the neutral pH of cytosol, nuclei, and extracellular locations. Importantly, cathepsin B displays different substrate cleavage properties at acidic pH compared to...
The Relationship Between Exercise, Cathepsin B, and Cognitive Functions: Systematic Review.
Publication Type: Academic Journal
Source(s): Perceptual and motor skills [Percept Mot Skills] 2023 Aug; Vol. 130 (4), pp. 1366-1385. Date of Electronic Publication: 2023 May 18.
Abstract: Exercise has been shown repeatedly to improve cognitive functions. Many investigators have reported that peripheral signal molecules play an important role in regulating exercise-induced cognitive improvement. In this review we aimed to evaluate and cl...
Macropinoscope: Real-Time Simultaneous Tracking of pH and Cathepsin B Activity in Individual Macropinosomes.
Publication Type: Academic Journal
Source(s): Analytical chemistry [Anal Chem] 2023 Aug 01; Vol. 95 (30), pp. 11410-11419. Date of Electronic Publication: 2023 Jul 19.
Abstract: A fluorescent sensor that allows simultaneous analysis of environmental factors in a limited cellular space is useful for understanding precise molecular interactions in live cells and their biological responses. Macropinocytosis is a ubiquitous endocy...
Selection of an Amino Acid Site with One of the Fastest Cleavage Kinetics by the Endosomal Protease Cathepsin B for Potential Use in Drug Delivery Systems.
Publication Type: Academic Journal
Source(s): Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2023 Apr; Vol. 509 (1), pp. 78-80. Date of Electronic Publication: 2023 Jun 20.
Abstract: On the basis of known published data, six peptide sequences were selected that are potentially capable of being rapidly cleaved by the endosomal protease cathepsin B. For comparison, the cleavage of common linker sequences, polyglycine and polyglycine-...