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 "CHEMICAL synthesis"
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Continuous Synthesis of Cinnarizine Salt with Malic Acid by Applying Green Chemistry Using Water-Assisted Twin Screw Extrusion.

Publication Type: Academic Journal

Source(s): Molecular pharmaceutics [Mol Pharm] 2023 Oct 02; Vol. 20 (10), pp. 5160-5172. Date of Electronic Publication: 2023 Aug 30.

Abstract: Organic solvent-free process or green chemistry is needed for manufacturing pharmaceutical salts to avoid various environmental, safety, and manufacturing cost issues involved. In this study, a cinnarizine (CNZ) salt with malic acid at a 1:1 molar rati...

Carbon-to-nitrogen single-atom transmutation of azaarenes.

Publication Type: Academic Journal

Source(s): Nature [Nature] 2023 Nov; Vol. 623 (7985), pp. 77-82. Date of Electronic Publication: 2023 Nov 01.

Abstract: When searching for the ideal molecule to fill a particular functional role (for example, a medicine), the difference between success and failure can often come down to a single atom 1 . Replacing an aromatic carbon atom with a nitrogen atom would be en...

Lipidated variants of the antimicrobial peptide nisin produced via incorporation of methionine analogs for click chemistry show improved bioactivity.

Publication Type: Academic Journal

Source(s): The Journal of biological chemistry [J Biol Chem] 2023 Jul; Vol. 299 (7), pp. 104845. Date of Electronic Publication: 2023 May 19.

Authors:

Abstract: The increase in antibiotic resistance calls for accelerated molecular engineering strategies to diversify natural products for drug discovery. The incorporation of non-canonical amino acids (ncAAs) is an elegant strategy for this purpose, offering a di...

Facile synthesis of amino-functionalized magnetic materials for efficient enrichment of anionic metabolites from biological samples.

Publication Type: Academic Journal

Source(s): Analytica chimica acta [Anal Chim Acta] 2023 Apr 15; Vol. 1250, pp. 340977. Date of Electronic Publication: 2023 Feb 15.

Authors:

Abstract: The analysis of biological samples is often affected by the background matrix. Proper sample preparation is a critical step in the analytical procedure for complex samples. In this study, a simple and efficient enrichment strategy based on Amino-functi...

Carbon 14 synthesis of glycine transporter 1 inhibitor Iclepertin (BI 425809) and its major metabolites.

Publication Type: Academic Journal

Source(s): Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2023 Sep; Vol. 66 (11), pp. 336-344. Date of Electronic Publication: 2023 Jun 29.

Abstract: Carbon 14 labeled Iclepertin (BI 425809, 1) and its major metabolites were needed for ADME and several other studies necessary for the advancement of this drug candidate in clinical trials. Iclepertin is composed of two main chemical blocks, (R)-5-(met...

Fork- and Comb-like Lipophilic Structures: Different Chemical Approaches to the Synthesis of Oligonucleotides with Multiple Dodecyl Residues.

Publication Type: Academic Journal

Source(s): International Journal of Molecular Sciences. Oct2023, Vol. 24 Issue 19, p14637. 12p.

Abstract: Lipophilic oligonucleotide conjugates represent a powerful tool for nucleic acid cellular delivery, and many methods for their synthesis have been developed over the past few decades. In the present study, a number of chemical approaches for the synthe...

Synthesis and Anticancer Evaluation of New Indole-Based Tyrphostin Derivatives and Their ( p -Cymene)dichloridoruthenium(II) Complexes.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2023 Jan 03; Vol. 24 (1). Date of Electronic Publication: 2023 Jan 03.

Abstract: New N -alkylindole-substituted 2-(pyrid-3-yl)-acrylonitriles with putative kinase inhibitory activity and their ( p -cymene)Ru(II) piano-stool complexes were prepared and tested for their antiproliferative efficacy in various cancer models. Some of the...

SYNTHESIS OF S,P,N-CONTAINING ORGANIC COMPOUNDS AND THEIR THERMOSTABILITY WITH RESPECT TO METALS.

Publication Type: Academic Journal

Source(s): Azerbaijan Chemical Journal. 2023, Issue 4, p97-103. 7p.

Abstract: The results of thermal studies of some derivatives of dithiophosphoric, xanthogenic, dithiocarbamic acids are presented. The thermal parameters of the compounds were determined both in pure form and in the presence of iron and copper powders. Their che...

Chemical Synthesis of Selenium-containing Peptides.

Publication Type: Academic Journal

Source(s): Mini reviews in medicinal chemistry [Mini Rev Med Chem] 2023; Vol. 23 (10), pp. 1090-1117.

Abstract: Selenium (Se), a semi-metallic element, has chemical properties similar to sulfur; however, it has comparatively low electronegativity as well as a large atomic radius than sulfur. These features bestow selenium-containing compounds with extraordinary ...

Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors.

Publication Type: Academic Journal

Source(s): Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2198163.

Abstract: Novel series of aminopyrimidines bearing a biologically active cyclohexenone 3a-f and oxo-selaneylidene moiety 4 , besides selenadiazolopyrimidines ( 5a-e and 7 ), were synthesised using 5,6-diaminouracils as starting materials. Compound 3a exhibited s...

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